Results 141 to 150 of about 536,462 (222)

Computed tomography reveals the endocranial anatomy of Crocodylia: Implications for phylogenetic relationships and ecomorphological convergence across Crocodylomorpha

Journal of Anatomy, EarlyView.
The evaluation of the endocranial anatomy of 43 crocodylian species reveals several differences, including variation in the curvature of the encephalic endocast, the size of the endosseous labyrinth and paratympanic sinuses, and the presence of additional snout sinuses.
Paul M. J. Burke, Philip D. Mannion
wiley   +1 more source

Intracranial brain parenchymal spread of mucormycosis through olfactory tract: a diffusion-weighted imaging-based concept. [PDF]

Acta Radiol Open, 2020
Sandron J, Hantson P, Duprez T.
europepmc   +1 more source

CHARGE Syndrome: A Narrative Review and Update on Diagnosis, Assessment and Management

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Background CHARGE syndrome (CS) is a rare multisystemic genetic condition caused by a pathogenic variant in the DNA‐binding protein‐7 CHD7 gene. The condition affects the development of neural crest cells, which give rise to craniofacial structures, cranial nerves, ears, eyes and the heart, resulting in diverse and complex clinical features ...
Eleni M. van Gelder, Suzanna E. L. Temple, Niall Jefferson, David Brown, Kasee Stratton‐Gadke, Madelene Rich, Steve Rose, Kim Blake   +7 more
wiley   +1 more source

GLP‐1 Receptor Agonists and Weight Loss: A Critical Review of Mechanisms

Obesity Reviews, EarlyView.
ABSTRACT GLP‐1 receptor agonist medications have the potential to promote marked weight loss, but maximal and sustained benefit may be compromised by poor compliance and cessation of use. Development of next‐generation medications that address current obstacles to effective use and development of effective adjunct treatments will benefit from better ...
Giorgia Rutigliani, Tzu‐Wen L. Cross, Erica de Jong, Emily S. Glover, Ivan D. Mendoza, Mojisola Adisa, Keigo Tomoo, Xinyi Zhou, Richard D. Mattes   +8 more
wiley   +1 more source

TMEM16A Ca2+‐activated Cl− channel: Functional interactions with cytoskeletal and membrane‐associated proteins

The Journal of Physiology, EarlyView.
Abstract figure legend The calcium‐activated chloride (ClCa) channel TMEM16A (also known as ANO1) plays critical roles in ion transport, neurotransmission and smooth muscle contraction. Dysregulation of TMEM16A channel activity contributes to the development and progression of various diseases.
Hisao Yamamura, Rubii Kondo, Yoshiaki Suzuki, Yuji Imaizumi, Aya Yamamura   +4 more
wiley   +1 more source

Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes

The Journal of Physiology, EarlyView.
Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière, Thomas Boulin, Maëlle Jospin, Alexandre Janin, Gilles Millat, Philippe Chevalier, Olga Andrini   +6 more
wiley   +1 more source

Characterization of postnatal brain injury and behavioural deficits in a rat model of placental insufficiency‐induced fetal growth restriction

The Journal of Physiology, EarlyView.
Abstract figure legend Fetal growth restriction (FGR) is a common pregnancy complication associated with long‐term neurodevelopmental impairments. Using the reduced uterine perfusion pressure (RUPP) rat model of placental insufficiency‐induced FGR, this study demonstrates that FGR leads to persistent anatomical, histological and behavioural ...
Judit Alhama‐Riba, Caroline G. M. de Theije, Valentina Salvi, Dominique Viveen, Sebastiaan W. T. Corstjens, Marijke. E. J. Achterberg, Yohan van de Looij, Freek E. Hoebeek, Cora H. A. Nijboer   +8 more
wiley   +1 more source

Drafting the calmodulation playbook: Emerging structural insights into transient receptor potential channel regulation by calmodulin

The Journal of Physiology, EarlyView.
Abstract figure legend Calmodulin (CaM) is a ubiquitous calcium (Ca2+) sensor that translates intracellular Ca2+ signals into modulation of hundreds of effector proteins including ion channels. CaM is increasingly recognized as a key regulator of the transient receptor potential (TRP) channel family, yet the underlying ‘calmodulation playbook’ is only ...
Aden M. Alemayhu, Candice E. Paulsen
wiley   +1 more source

Availability of olfactory bulb: experience from a British Brain Bank

Arquivos de Neuro-Psiquiatria
The olfactory bulb and tract (OB/OT) are among the earliest structures in the brain to undergo pathological changes in many neurodegenerative conditions.
Suraj Rajan, Linda Parsons, Andrew J Lees, Laura Silveira-Moriyama   +3 more
doaj  

Synchrony within Aβ mechanoreceptor subtypes governs signal propagation to primary somatosensory cortex

The Journal of Physiology, EarlyView.
Abstract figure legend We used an optogenetic gain‐of‐function manipulation to investigate how sensory signals from two subtypes of Aβ low threshold mechanoreceptors (LTMRs) contribute to the cortical representation of touch. CatCh, a sensitive and fast channelrhodopsin variant, enables pulsed‐light generation of high‐frequency action potential trains ...
Wanyi Liu, Andrew E. Worthy, Alan J. Emanuel   +2 more
wiley   +1 more source