Heterogeneous extracellular dopamine regulation in the subregions of the olfactory tubercle [PDF]
Journal of Neurochemistry, 2017 AbstractRecent studies show that dense dopamine (DA) innervation from the ventral tegmental area to the olfactory tubercle (OT) may play an important role in processing multisensory information pertaining to arousal and reward, yet little is known about DA regulation in the OT. This is mainly due to the anatomical limitations of conventional methods of
Jinwoo Park +3 more
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The Olfactory Tubercle Encodes Odor Valence in Behaving Mice [PDF]
The Journal of Neuroscience, 2015 Sensory information acquires meaning to adaptively guide behaviors. Despite odors mediating a number of vital behaviors, the components of the olfactory system responsible for assigning meaning to odors remain unclear. The olfactory tubercle (OT), a ventral striatum structure that receives monosynaptic input from the olfactory bulb, is uniquely ...
Marie A. Gadziola +3 more
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Neuromodulator Dynamics Underlying Associative Learning in the Ventral Striatum's Olfactory Tubercle [PDF]
Advanced ScienceThe brain's neuromodulatory systems—particularly dopamine (DA), serotonin (5‐HT), acetylcholine (ACh), and norepinephrine (NE)—play a crucial role in reward processing and associative learning. The olfactory tubercle (OT), a region that overlaps with the
Maojun Hong +7 more
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Phasic dopamine reinforces distinct striatal stimulus encoding in the olfactory tubercle driving dopaminergic reward prediction [PDF]
Nature Communications, 2020 It is not entirely understood how network plasticity produces the coding of predicted value during stimulus-outcome learning. Here, the authors reveal a reinforcing loop in distributed limbic circuits, transforming sensory stimuli into reward prediction ...
Lars-Lennart Oettl +9 more
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Functional Sub-Circuits of the Olfactory System Viewed from the Olfactory Bulb and the Olfactory Tubercle [PDF]
Frontiers in Neuroanatomy, 2017 Understanding of the olfactory neural circuits has progressed beyond analysis of how odor information from the external environment is processed in the brain. While spatially-organized sub-circuits were found to exist up to the olfactory bulb (OB), the arrangement in the olfactory cortex (OC), especially in its representative piriform cortex (PC ...
Yamaguchi M.
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Opposing Roles of Dopamine Receptor D1- and D2-Expressing Neurons in the Anteromedial Olfactory Tubercle in Acquisition of Place Preference in Mice [PDF]
Frontiers in Behavioral Neuroscience, 2019 Olfaction induces adaptive motivated behaviors. Odors associated with food induce attractive behavior, whereas those associated with dangers induce aversive behavior.
Koshi Murata +10 more
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Olfactory tubercle mediates adaptive social behavior by controlling threat assessment and the expression of social threat memories during recall in male mice [PDF]
Nature CommunicationsThe ability to dynamically assess and update threat responses based on changing environmental contexts is fundamental for survival. Here, we developed an odor-based paradigm where male mice encounter a restrained conspecific that subsequently becomes ...
Giulia Casarotto +3 more
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Olfactory tubercle stimulation alters odor preference behavior and recruits forebrain reward and motivational centers [PDF]
Frontiers in Behavioral Neuroscience, 2014 Rodents show robust behavioral responses to odors, including strong preferences or aversions for certain odors. The neural mechanisms underlying the effects of odors on these behaviors in animals are not well understood. Here, we provide an initial proof-
Brynn J FitzGerald +2 more
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Risperidone regulates the expression of schizophrenia-related genes in the forebrain of adult male mice [PDF]
Frontiers in Molecular NeuroscienceIntroductionRisperidone is a widely used antipsychotic that reduces psychotic symptoms through modulation of monoaminergic signaling. At the cellular level, however, its effects extend beyond receptor antagonism and induce spatially discrete ...
Magdalena Ziemiańska +8 more
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Striatal hub of dynamic and stabilized prediction coding in forebrain networks for olfactory reinforcement learning [PDF]
, 2022 Identifying the circuits responsible for cognition and understanding their embedded computations is a challenge for neuroscience. We establish here a hierarchical cross-scale approach, from behavioral modeling and fMRI in task-performing mice to cellular
Meyer-Lindenberg, Andreas +31 more
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