Results 51 to 60 of about 51,216 (167)

Programmable Nanoscale Motion via Molecular Patterning on DNA Origami

Angewandte Chemie, EarlyView.
DNA origami nanorods enable precise urease placement with tunable coverage and asymmetry, revealing that propulsion depends on a balance of catalytic loading and geometry. Maximum speed occurs at ∼25% end‐coverage and declines as enzyme distribution becomes more symmetrical.
Lars Paffen, Maurik Engelbert van Bevervoorde, Andoni Rodriguez‐Abetxuko, Loai Abdelmohsen, Remco van der Hofstad, Jan C.M. van Hest, Tania Patiño Padial   +6 more
wiley   +2 more sources

Strontium and Osteoporosis

Türk Osteoporoz Dergisi, 2004
Osteoporosis (OP) is a condition of bone fragility resulting from micro-architectural deterioration and decreased bone mass. OP depends on the interaction of genetic, hormonal, environmental and nutritional factors.
Ferda Özdemir, Esra Esen
doaj  

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Geochemistry and petrogenesis of the Feshark intrusion (NE Isfahan city)

Journal of Economic Geology, 2017
Introduction Granitic rocks are the most abundant rock types in various tectonic settings and they have originated from mantle-derived magmas and/or partial melting of crustal rocks.
Ali Kananian, Fatemeh Ghahramani, Fatemeh Sarjoughian, Jamshid Ahmadian , Kazem Kazemi   +4 more
doaj   +1 more source

Versatile CRISPR‐Cas Tools for Gene Regulation in Zebrafish via an Enhanced Q Binary System

Advanced Science, EarlyView.
This study introduces CRISPR‐Q, a transgenic CRISPR‐Cas system leveraging the QFvpr/QUAS binary expression platform in zebrafish. CRISPR‐Q overcomes previous challenges in achieving stable and efficient gene regulation. By enabling precise spatiotemporal control of transcript knockdown (CRISPR‐QKD) and gene activation (CRISPR‐Qa), it provides a ...
Miaoyuan Shi, Weiqi Ge, Changheng Li, Bin Liu, Xiaoyi Deng, Chengjie Liu, Meijun Zheng, Pu Zhang, Lei Li, Ying Guo, Yunqi Han, Yu Yang, Yanxun V. Yu, Youngnam N. Jin   +13 more
wiley   +1 more source

From Natural Discovery to AI‐Guided Design: A Curated Collection of Compact Enhancers for Crop Engineering

Advanced Science, EarlyView.
ABSTRACT Precise transgene‐free gene upregulation remains a challenge in crop biotechnology, as conventional enhancers often exceed CRISPR‐mediated knock‐in size constraints and face regulatory hurdles. Here we establish a foundational cross‐species resource of compact transcriptional enhancers developed via STEM‐seq, a high‐throughput screening ...
Qi Yao, Jin Gao, Keling Wang, Yufeng Liu, Peijin Han, Hong Pan, Xiaofeng Yang, Qianlan Yin, Dating Zhong, Lu Ye, Qi Deng, Lingling Gao, Xiaoyu Tu, Dequan Wang, Yuming Lu   +14 more
wiley   +1 more source

Nanozymes Integrated Biochips Toward Smart Detection System

Advanced Science, EarlyView.
This review systematically outlines the integration of nanozymes, biochips, and artificial intelligence (AI) for intelligent biosensing. It details how their convergence enhances signal amplification, enables portable detection, and improves data interpretation.
Dongyu Chen, Wang Zheng, Zhihui Zhang, Shenping Yu, Xinxin Hang, Han Wu, Xiao‐Wei Xiang, Wei Mu, Yanli Jiao, Zaizai Dong, Lingqian Chang   +10 more
wiley   +1 more source

Investigation of petrography, mineralogy and alteration of northern part of the Chahfiruzeh porphyry copper deposit, northwest of Shar-e-Babak, Kerman

Journal of Economic Geology, 2019
Introduction The Chahfiruzeh porphyry copper deposit is located at 35 Km northwest of Shar-e-Babak in Dehaj–Sarduieh part of the Urumieh- Dokhtar magmatic arc (UDMA).
Mohammad Boomeri, Habib Biabangard, Zahra Zeinadini   +2 more
doaj   +1 more source

Selenoprotein H Functions as a PPARα Coactivator to Link Selenium Homeostasis to Hepatic Lipid Metabolism and Protect against Steatohepatitis

Advanced Science, EarlyView.
Our study identifies selenium deficiency as a hallmark of MASH pathogenesis. Dietary selenium supplementation enhances hepatic fatty acid oxidation (FAO) and attenuates MASH progression by activating the PPARα pathway via selenoprotein H (SELENOH). This selenium‐SELENOH‐PPARα nexus redefines the functional scope of selenoproteins, moving from redox ...
Yuwei Zhang, Yuchen Wang, Binbin Li, Xin Li, Chenyu Liu, Yanhao Chen, Cheng Tian, Dongmei Wang, Xiaosong Gu, Chunping Jiang, Yuda Wei, Qiurong Ding   +11 more
wiley   +1 more source

Meso‐Crowned Porphyrin as a Dual Cavity Hybrid Macrocycle for Improving the Efficiency and Stability of Perovskite Solar Cells

Advanced Science, EarlyView.
This study demonstrates a dual‐functional porphyrin‐based passivation molecule, [12]‐C‐4POR, capable of simultaneously coordinating Pb2+ and Li+ ions through its porphyrin core and crown ether moiety, respectively. This molecule effectively reduces trap‐state density, suppresses non‐radiative recombination, and mitigates Li+ migration at the perovskite/
Muhammad Ans, Murat Ebic, Rafał A. Grzelczak, Joanna Kruszyńska, Kostiantyn Nikiforow, Pankaj Yadav, Bartosz Szyszko, Seckin Akin, Daniel Prochowicz   +8 more
wiley   +1 more source