Results 121 to 130 of about 1,124,993 (188)

Kinetochore mutations and histone phosphorylation pattern changes accompany holo- and macro-monocentromere evolution. [PDF]

Nat Commun
Kuo YT, Neumann P, Chen J, Fuchs J, Schubert V, Kumke K, Sader MA, Melzer M, Zhu Z, Himmelbach A, Hentrich H, Macas J, Houben A.   +12 more
europepmc   +1 more source

Multi‐regional Organoid Biobank Reveals FAK‐ACSL1‐Driven Doxorubicin‐Resistance and Predictive Biomarkers in Breast Cancer

Advanced Science, Volume 13, Issue 55, 5 October 2026.
This study established a high‐quality organoid biobank derived from 68 tumor sites across 50 Chinese patients, elucidated the drug sensitivity‐based molecular subtyping in breast cancer, and revealed a novel mechanism of drug resistance mediated by the FAK‐ACSL1 pathway.
Hao Xu, Zhijun Qin, Jiapeng Yang, Baoyuan Zhang, Manqing Cao, Peng Wang, Zaiqi Wang, Jinghui Cheng, Lei Wang, Hong Liu, Hui Yang   +10 more
wiley   +1 more source

Unveiling centromeric retrotransposon dynamics through a high-quality rye genome assembly. [PDF]

Nat Commun
Chen E, Wehrkamp CM, Jhingan S, Lux T, Zhu Z, Chen J, Tulpová Z, Himmelbach A, Fuchs J, Feng JW, Rabanus-Wallace MT, Šimková H, Spannagl M, Mascher M, Wicker T, Houben A, Stein N.   +16 more
europepmc   +1 more source

Distribution of Big Tau Isoforms in the Human Central and Peripheral Nervous System

Annals of Neurology, Volume 100, Issue 4, Page 709-736, October 2026.
Objective Tau is widely studied in neurodegeneration, yet most work has focused on canonical brain tau isoforms. A longer isoform, “big tau,” produced by inclusion of exon 4a, is expressed in the peripheral nervous system (PNS) and central nervous system (CNS) regions.
Rama Krishna Koppisetti, Nicolas R. Barthélemy, Kanta Horie, Cindy V. Ly, Kaleigh F. Roberts, Srinivas Koutarapu, Richard J. Perrin, Erin E. Franklin, Chiara Pedicone, Joshua Orrick, Justin Melendez, Timothy M. Miller, Chihiro Sato, Nupur Ghoshal, Alison M. Goate, Celeste M. Karch, Randall J. Bateman, Soumya Mukherjee   +17 more
wiley   +1 more source

"End-to-End Chromosome Fusion" as the Main Driver of Descending Dysploidy in <i>Vigna lasiocarpa</i> (Mart. ex Benth.) Verdc. (Leguminosae Juss.). [PDF]

Plants (Basel)
Serafim L, Silva JH, Dias S, Oliveira ARDS, Nunes MC, da Costa AF, Benko-Iseppon AM, Jiang J, do Vale Martins L, Brasileiro-Vidal AC.   +9 more
europepmc   +1 more source

β2 Adrenoceptor Signaling Modulates Myoblast Differentiation via miR‐374b‐5p/GSK3β and miR‐326‐3p/Tnfrsf11a Axes

Cell Biology International, Volume 50, Issue 10, October 2026.
ABSTRACT Myoblast differentiation is a crucial step of skeletal muscle regeneration and is impaired in the absence of the β2 adrenoceptor (ADRβ2). Since miR‐374b and miR‐326 regulate cell differentiation, this study investigated if ADRβ2 regulates myoblast differentiation via miR‐374b‐5p and miR‐326‐3p. Primary myoblasts from ADRβ2 knockout (β2KO) mice
Tatiana E. Koike, Cesar S. Fuziwara, Audrei R. Santos, Fernanda V. B. Delpupo, Tábata L. Nascimento, Andrei Rozanski, Marcelo G. Pereira, Patrícia C. Brum, Edna T. Kimura, Thomas A. Rando, Elen H. Miyabara   +10 more
wiley   +1 more source

Phased-genome assemblies of saltgrass reveal structural dynamics and genomic basis for extreme salt tolerance and dioecy. [PDF]

Plant Commun
Nawaz K, Orduna IO, Koo DH, Molina-Freaner F, Bell HL, Miculan M, Llaca V, Harrington J, Eppley S, Poland J.   +9 more
europepmc   +1 more source

Hypothalamus Participates in Peripheral Sympathetic Hyperactivity After Acute Brain Injury by Regulating Trhr M6A Modification

MedComm, Volume 7, Issue 10, October 2026.
In acute brain injury (TBI/ICH), sympathetic hyperactivity is driven by hypothalamic FTO upregulation. FTO demethylates Trhr, blocking m6A‐YTHDF2‐dependent degradation, which stabilizes Trhr mRNA and increases neuronal sensitivity to TRH. Restoring FTO or Trhr alleviates sympathetic hyperactivity, offering a potential target for managing autonomic ...
Maoxing Fei, Handong Wang, Chaochao Gao, Shiqiao Luo, Xiwen Huang, Yanling Han, Mengliang Zhou, Zhenxing Li   +7 more
wiley   +1 more source

Asymmetric evolution of satellite DNA on homologous and homeologous chromosomes in allotetraploid Narenga porphyrocoma. [PDF]

BMC Plant Biol
Huang S, Zhang M, Yang Y, Yang J, Wang Z, Deng Z, Xu L, Huang Y.   +7 more
europepmc   +1 more source

Blocking Extracellular Cyclophilin A‐Mediated Adhesion Protects Against Bacterial Infection

MedComm, Volume 7, Issue 10, October 2026.
eCypA promotes bacterial infection by upregulating TGF‐β signaling‐dependent adhesion receptor expression. Pathogens such as IAV, GAS, S. P., and K. P. induce eCypA secretion. Binding of eCypA with TβR2 enhances the affinity of TGF‐β1 and TβR2, which positively regulates adhesion receptors expression via the TGF‐β/Smad signaling pathway, thereby ...
Xiaoyuan Bai, Heqiao Li, Pengtao Jiao, Yuna Zhao, Xiaoxiao Jia, Han Zhong Pei, Zeqiu Fan, Runshan Lin, He Zhang, Beinan Wang, Xinhai Chen, Yuhai Bi, De Chang, Zhongfa Zhang, Yuxin Chen, Wenjun Liu, Lei Sun   +16 more
wiley   +1 more source