Results 91 to 100 of about 190,260 (351)

Alzheimer Amyloid-β Oligomer Bound to Post-Synaptic Prion Protein Activates Fyn to Impair Neurons

Nature Neuroscience, 2012
Amyloid-beta (Aβ) oligomers are thought to trigger Alzheimer's disease pathophysiology. Cellular prion protein (PrPC) selectively binds oligomeric Aβ and can mediate Alzheimer's disease–related phenotypes.
J. Um, H. Nygaard, Jacqueline K. Heiss, M. Kostylev, M. Stagi, A. Vortmeyer, T. Wisniewski, E. Gunther, S. Strittmatter   +8 more
semanticscholar   +1 more source

Identification and characterization of a gene conferring stress resistance in Escherichia coli and cyanobacteria

FEBS Open Bio, EarlyView.
Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada, Takaaki Tanaka, Manaka Uehara, Keigo Nakano, Ken Morishima, Rintaro Inoue, Masaaki Sugiyama, Masafumi Yohda   +7 more
wiley   +1 more source

5-Hydroxycyclopenicillone Inhibits β-Amyloid Oligomerization and Produces Anti-β-Amyloid Neuroprotective Effects In Vitro

Molecules, 2017
The oligomer of β-amyloid (Aβ) is considered the main neurotoxin in Alzheimer’s disease (AD). Therefore, the inhibition of the formation of Aβ oligomer could be a target for AD therapy.
Jiaying Zhao, Fufeng Liu, Chunhui Huang, Jieyi Shentu, Minjun Wang, Chenkai Sun, Liping Chen, Sicheng Yan, Fang Fang, Yuanyuan Wang, Shujun Xu, C. Benjamin Naman, Qinwen Wang, Shan He, Wei Cui   +14 more
doaj   +1 more source

Passive Immunization with Tau Oligomer Monoclonal Antibody Reverses Tauopathy Phenotypes without Affecting Hyperphosphorylated Neurofibrillary Tangles

Journal of Neuroscience, 2014
Recent findings suggest that tau oligomers, which form before neurofibrillary tangles (NFTs), are the true neurotoxic tau entities in neurodegenerative tauopathies, including Alzheimer's disease (AD).
Diana L. Castillo-Carranza, Urmi Sengupta, Marcos J. Guerrero-Muñoz, C. Lasagna-Reeves, Julia E. Gerson, Gurpreet Singh, D. Estes, Alan D. T. Barrett, K. Dineley, G. Jackson, R. Kayed   +10 more
semanticscholar   +1 more source

Biophysical Methods for Attomolar Detection of Compounds Acting on Protein Oligomer States [PDF]

Few protocols exist today that demonstrate repeatable resolution of small molecule interactions with target proteins at extremely low analyte levels, particularly at sub-femtomolar levels.
Stephanie, Krzypkowski, Wayne, Guida, Mark, Eschenfelder, William, Lawless, Robert, Sparks, Kenyon, Daniel   +5 more
core   +1 more source

Protein oligomer modeling guided by predicted interchain contacts in CASP14

, 2021
For CASP14, we developed deep learning-based methods for predicting homo-oligomeric and hetero-oligomeric contacts and used them for oligomer modeling.
Ivan Anishchenko, Baker, David, Anishchenko, Ivan, Minkyung Baek, Park, Hahnbeom, Ian R. Humphreys, Hahnbeom Park, David Baker, Baek, Minkyung, Humphreys, Ian R.   +9 more
core   +1 more source

Characterizing Cutaneous α‐Synuclein Deposition and Seeding Activity in Parkinson's Disease Subtypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cutaneous phosphorylated α‐synuclein (p‐syn) and α‐synuclein seeding activity are promising biomarkers for Parkinson's disease (PD), but their clinical value remains uncertain due to disease heterogeneity. This study evaluates these two biomarkers in PD patients to inform phenotype‐specific diagnosis and disease severity assessment ...
Yuting Jin, Tianyuan Yang, Minglei Liu, Haiyang Luo, Jing Yuan, Ke Zhang, Xinsheng Han, Jing Yang, Yuming Xu   +8 more
wiley   +1 more source

Inducing Axial Chirality in a "Geländer" Oligomer by Length Mismatch of the Oligomer Strands

, 2014
Helical molecules are not only esthetically appealing due to their structural beauty, they also display unique physical properties as a result of their chirality.
Neuburger, M., Mayor, M., Gsellinger, H., Zimmermann, K., Mayor, Marcel, Rickhaus, Michel, Neuburger, Markus, Häussinger, Daniel, Bannwart, Linda Maria, Häussinger, D., Zimmermann, Kaspar, Bannwart, L. M., Gsellinger, Heiko, Rickhaus, M.   +13 more
core   +1 more source

Adaptive Foam 3D Printing of Ultralight and Multifunctional Materials

Advanced Engineering Materials, EarlyView.
Adaptive foam 3D printing, enabled by expandable microspheres, imparts cellular structures to thermoplastic and thermosetting polymers, manufactured through a variety of processes including fused filament fabrication, direct ink writing, digital light processing, and inkjet printing.
Nariman Rajabifar, Amir Ameli
wiley   +1 more source

Sustained Intermittent Hypoxemia Induces Adiponectin Oligomers Redistribution and a Tissue-Specific Modulation of Adiponectin Receptor in Mice

Frontiers in Physiology, 2019
Introduction: Hypoxemia is a critical component of several respiratory diseases and is known to be involved in the processes underlying co-morbidities associated to such disorders, notably at the cardiovascular level. Circulating level of Adiponectin (Ad)
Mélany Pierard, Alexandra Tassin, Stéphanie Conotte, Karim Zouaoui Boudjeltia, Alexandre Legrand   +4 more
doaj   +1 more source