Results 171 to 180 of about 92,702 (304)

Blood Amyloid-β Reduction Following Chongnoi-tang Treatment in Alzheimer's Spectrum Conditions: A Retrospective Pilot Observational Study. [PDF]

J Clin Med
Lee J.
europepmc   +1 more source

The Cytoplasmic MicroRNA‐Production Complex Regulates MicroRNA Sorting to Extracellular Vesicles During Synaptogenesis

Advanced Science, EarlyView.
The mechanisms of microRNA cargo sorting to extracellular vesicles, important mediators of cell communication, are not fully understood. This study reveals that the microRNA‐production machinery acts as a ‘hub’ for the sorting of microRNAs to extracellular vesicles, a process regulated by dynamic organelle interactions.
Yuzhou Zeng, Selina Luhmann, Aditi Saha, Marta Orlando, Haider Sami, Timo Glatter, Anna Antoniou   +6 more
wiley   +1 more source

Decoding Biomolecular Phase Separation: From Physiological Roles to Pathological Mechanisms and Therapeutic Biomaterials Design

Advanced Science, EarlyView.
This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu, Jingbo Dong, Qiufang Gong, Xuejiao Song, Zhifa Shen, Chao Liang   +5 more
wiley   +1 more source

Multipathway Aggregation Drives Concentration-Dependent Amyloid Polymorphism and Time-Dependent Morphological Evolution. [PDF]

J Phys Chem Lett
Bhandari K, Xiong W, Hou T, Ke PC, Ding F.   +4 more
europepmc   +1 more source

Decoding Interfacial Polymerization Through Steady Amine Delivery and Real‐Time QCM‐D Monitoring

Advanced Science, EarlyView.
We combine steady amine delivery with in situ quartz crystal microbalance with dissipation to track interfacial polymerization in real time. The platform resolves three kinetic regimes: pre‐gelation oligomerization, post‐gelation aggregation and network growth, and diffusion‐limited film evolution.
Yu Fang, Yu‐Ren Xue, Cheng‐Ye Zhu, Hong‐Qing Liang, Zhi‐Kang Xu   +4 more
wiley   +1 more source

Phase Equilibria and Morphology of the TPU-Tactix-DGEBA Ternary System: Interference Approach and SEM Analysis. [PDF]

Polymers (Basel)
Ponomarenko AD, Plyusnina IO, Nikulova UV, Shapagin AV.   +3 more
europepmc   +1 more source

A ROS‐Responsive and Mucoadhesive Thermosensitive Hydrogel Encapsulated with Mizoribine for Synergistic Dry Eye Therapy

Advanced Science, EarlyView.
The ROS‐responsive in situ thermosensitive MZR@SPPP hydrogel system enables dual‐stage drug loading and sustained ocular delivery. Upon administration, it gelates at ocular surface temperature, enhancing ocular adhesion. By scavenging free radicals, restoring NRF2‐mediated antioxidant defense and mitochondrial homeostasis, and suppressing inflammatory ...
Danyi Qin, Jiani Li, Panqin Ma, Shinan Wu, Wenying Guan, Yimin Huang, Ke Feng, Mingyan Wei, Zixuan Yang, Shujia Guo, Caihong Huang, Yun‐Long Wu, Yi Han, Zuguo Liu   +13 more
wiley   +1 more source

Riluzole shifts glial responses to protect synapses and memory in Aβ oligomer-treated rats. [PDF]

J Neuroinflammation
Min-Kaung-Wint-Mon, Kida H, Kimura R, Mitsushima D.   +3 more
europepmc   +1 more source

Determination of Gene‐Level Fitness Contributions Across the Mucin‐Utilization Network of Bacteroides thetaiotaomicron

Advanced Science, EarlyView.
Genome‐wide CRISPRi and RNA‐seq resolve how B. thetaiotaomicron converts host mucosal glycans into fitness. The study reveals a layered mucin‐utilization architecture in which capsular polysaccharides constrain surface access, extracellular CAZymes and peptidases show functional redundancy, and intracellular catabolic pathways create discrete metabolic
Kangsan Kim, Jiwon Lee, Minjeong Kang, Sung Sun Yim, Donghui Choe, Byung‐Kwan Cho   +5 more
wiley   +1 more source

Investigating a relation between amyloid beta plaque burden and accumulated neurotoxicity caused by amyloid beta oligomers. [PDF]

Med Biol Eng Comput
Kuznetsov AV.
europepmc   +1 more source