Results 251 to 260 of about 190,260 (351)

Continuous and Large‐Scale: ELEANOR, the Soft Architected Arm Inspired by the Elephant Trunk

Advanced Intelligent Systems, EarlyView.
A large‐scale, architected continuum robot inspired by the macroscopic properties of the African elephant trunk achieves adaptive elephant‐like movements and whole‐body grasping. The results demonstrate that designing from the natural system’s macroscopic properties, rather than prescribing behaviors, provides a powerful strategy for developing ...
Giovanna A. Naselli, Anderson B. Nardin, Seonggun Joe, Ryan Drinkwater, Enrico Donato, Diego Bianchi, Egidio Falotico, Michel C. Milinkovitch, Lucia Beccai   +8 more
wiley   +1 more source

Structure-Activity Relationship Study of Protoberberine Alkaloids Reveals Molecular Planarity as a Key Determinant of Membrane Interaction and Protection from Misfolded Protein Oligomers. [PDF]

J Med Chem
Errico S, Bigi A, Fani G, Ambrosino M, Galmiche E, Bemporad F, Vendruscolo M, Mannini B, Chiti F.   +8 more
europepmc   +1 more source

Functional Polymer‐Engineered Magnetic Nanoparticles as Dual‐Modal Theragnostic Probes for Early Alzheimer's Disease Detection and Therapy

Advanced NanoBiomed Research, EarlyView.
The nanoparticle consists of a 3 nm iron oxide core functionalized with an amphiphilic polymer coating containing Aβ‐targeting DSA moieties and biocompatible PEG chains. This design supports measurable transport in a BBB‐related model and specific interaction with Aβ species, while providing MRI contrast enhancement for diagnosis and therapeutic ...
Ao Shen, Liwen Zhang, Helen Forgham, Jiayuan Zhu, Xumin Huang, Changkui Fu, Ibrahim Javed, Thomas P. Davis, Ruirui Qiao   +8 more
wiley   +1 more source

Circulating Amyloid and Misfolded Biomarkers in Early Myocardial Injury: A Systematic Review and Epistemic Meta-Analysis. [PDF]

Int J Mol Sci
Chable-Guerrero FA, Romero-Zertuche D, Revilla-Monsalve C, Castrejón-Delgado L, Altamirano-Bustamante NF, Altamirano-Bustamante MM.   +5 more
europepmc   +1 more source

Expansion Microscopy Reveals the Spatial Association of Therapeutic Antibody–Receptor Complexes With Cholesterol‐Rich Membrane Domains

Angewandte Chemie, EarlyView.
We report a super‐resolution strategy that maps cholesterol‐rich membrane domains in whole, intact cells with an effective spatial resolution of ∼40 nm by combining expansion microscopy with a perfringolysin O domain 4 probe. This approach enables direct visualization of the spatial association between CD20 and CD38 complexes and cholesterol‐rich ...
Gang Wen, Nicole Seifert, Patrick Eiring, Johanna Meyer, Hannes Neuweiler, Julia Weingart, Ignacio Vega‐Vásquez, Sören Doose, Philip Kollmannsberger, Markus Sauer   +9 more
wiley   +1 more source

Oligomerization of PER2 as a dynamic mode of regulation of the mammalian circadian clock. [PDF]

Proc Natl Acad Sci U S A
Sanyal P, Sharma D, Viswan A, Crosby P, Narayanan V, Baumgartner J, Partch CL, Sekhar A.   +7 more
europepmc   +1 more source

Modifications of Lysine Residues 294 and 311 Within the Microtubule‐Binding Region Alter Tau Aggregation and Tubulin Binding Equilibria

Angewandte Chemie, EarlyView.
The molecular consequences of specific lysine modifications in Alzheimer´s disease remain insufficiently resolved in the context of full‐length protein. Here we integrate protein semisynthesis, segmental isotope labelling, and high‐resolution NMR spectroscopy to achieve residue‐resolved interrogation of site‐specific acetylation and carboxymethylation.
Dominik P. Vogl, Mario Migotti, Robert Konrat, Anne C. Conibear, Christian F. W. Becker   +4 more
wiley   +1 more source

Electrospun Liquid Crystal Elastomers as Stress-Free Thermo- and Photoresponsive Actuators. [PDF]

ACS Appl Mater Interfaces
Braidi N, Zanoni M, Turriani M, Rossi R, Triunfo C, Martella D, Masiero S, Parmeggiani C, Gualandi C.   +8 more
europepmc   +1 more source

Counterion Dynamics in Chiral Supramolecular Polymerization

Angewandte Chemie, EarlyView.
A single counterion acts as a dynamic structural element directing pathway‐dependent supramolecular polymerization. Subtle counterion repositioning governs molecular packing, aggregate morphology, supramolecular chirality, and asymmetry amplification. ABSTRACT Counterions have been studied in a broad range of chemical and biological systems, and their ...
Camila Montañez‐Moyano, Timo Krüger, Alejandro Martínez‐Manjarrés, Gustavo Fernández   +3 more
wiley   +1 more source