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Amyloid oligomers: formation and toxicity of Aβ oligomers
The FEBS Journal, 2010Alzheimer’s disease (AD) is an age‐related, progressive degenerative disorder that is characterized by synapse and neuron loss in the brain and the accumulation of protein‐containing deposits (referred to as ‘senile plaques’) and neurofibrillary tangles. Insoluble amyloid β‐peptide (Aβ) fibrillar aggregates found in extracellular plaques have long been
Masafumi, Sakono, Tamotsu, Zako
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ACS Nano, 2019 We developed a biodegradable photothermal therapeutic (PTT) agent, π-conjugated oligomer nanoparticles (F8-PEG NPs), for highly efficient cancer theranostics. By exploiting an oligomer with excellent near-infrared (NIR) absorption, the nanoparticles show
Zhongming Huang +2 more
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2019
The accumulation of tau filaments in neurons is a pathological hallmark of various neurodegenerative diseases, including Alzheimer's disease. However, it is not the filamentous aggregates themselves, but non-filamentous tau species, tau oligomer, that is thought to be the culprit in tau-mediated neurodegeneration.
Sumihiro, Maeda, Akihiko, Takashima
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The accumulation of tau filaments in neurons is a pathological hallmark of various neurodegenerative diseases, including Alzheimer's disease. However, it is not the filamentous aggregates themselves, but non-filamentous tau species, tau oligomer, that is thought to be the culprit in tau-mediated neurodegeneration.
Sumihiro, Maeda, Akihiko, Takashima
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Crystallization behaviour of oligomer-oligomer systems
Polymer Science U.S.S.R., 1981Abstract The heats of melting have been measured for three series of polyblock block copolymers of polyethylene oxide and polyarylate and for blends of analogous composition, and their degrees of crystallinity have been determined. Dependences of the heats of melting on the MW of crystalline and amorphous components, and on composition, are compared.
Yu.K Godovskii, Yu.D Shibanov
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Organic Letters, 2004
[structure: see text] Hydroxyaromatic aldehydes and ketones were used as building blocks to prepare ether oligomers. An iterative two-step protocol involving Mitsunobu coupling and carbonyl reduction provided a protecting-group-free route with high yields.
Renaudet O, Reymond JL
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[structure: see text] Hydroxyaromatic aldehydes and ketones were used as building blocks to prepare ether oligomers. An iterative two-step protocol involving Mitsunobu coupling and carbonyl reduction provided a protecting-group-free route with high yields.
Renaudet O, Reymond JL
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Bioorganic & Medicinal Chemistry, 2002
Glycamino acids, a family of sugar amino acids, are derivatives of C-glycosides that possesses a carboxyl group at the C-1 position and an amino group replacing one of the hydroxyl groups at either the C-2, 3, 4, or 6 position. We have prepared a series of glucose-type glycamino acids as monomeric building blocks: these are derivatives of 2-NH(2)-Glc ...
Yoshitomo, Suhara +7 more
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Glycamino acids, a family of sugar amino acids, are derivatives of C-glycosides that possesses a carboxyl group at the C-1 position and an amino group replacing one of the hydroxyl groups at either the C-2, 3, 4, or 6 position. We have prepared a series of glucose-type glycamino acids as monomeric building blocks: these are derivatives of 2-NH(2)-Glc ...
Yoshitomo, Suhara +7 more
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Stability of Amyloid Oligomers
2014Molecular simulations are now commonly used to complement experimental techniques in investigating amyloids and their role in human diseases. In this chapter, we will summarize techniques and approaches often used in amyloid simulations and will present recent success stories.
Workalemahu M, Berhanu +1 more
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Organic Semiconducting Oligomers for Use in Thin Film Transistors
Chemical Reviews, 2007Jean Fréchet, Amanda R Murphy
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