Results 201 to 210 of about 201,093 (287)

Fiber Reinforcement of Soft Spider Silk Hydrogels

Macromolecular Rapid Communications, EarlyView.
Along the development of matrices for biomedical applications, precise tuning of the biomaterial to interact with specific cell types/tissues is essential. The fabrication of fiber mesh‐reinforced soft hydrogels made of recombinant spider silk proteins allows for the adjustment of mechanical properties and hydrogel porosity, leading to improved cell ...
Christina Heinritz, Thomas Scheibel
wiley   +1 more source

Zika NS2B Protein: In Vitro Formation of Large Multimeric Networks. [PDF]

Int J Mol Sci
Ponniah C, Surya W, Torres J.
europepmc   +1 more source

Quantifying Protein–Glycan Interactions Using Native Mass Spectrometry

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Interactions between glycan‐binding proteins (GBPs) and carbohydrates (glycans) are essential to many biological processes relevant to human health and disease. For most GBPs, however, their glycan interactome—the repertoire of glycans recognized and their specificities—is poorly defined.
Duong T. Bui, Elena N. Kitova, Ling Han, Lara K. Mahal, John S. Klassen   +4 more
wiley   +1 more source

Large HERCs Function as Tumor Suppressors

Frontiers in Oncology, 2019
Taiane Schneider, Arturo Martinez-Martinez, Monica Cubillos-Rojas, Ramon Bartrons, Francesc Ventura, Jose Luis Rosa   +5 more
doaj   +1 more source

DNA Modulates Structural Transitions and Oligomerization Kinetics of the Functional Amyloid CRES. [PDF]

J Am Chem Soc
Kukreja R, Canny MD, Cornwall GA, Latham MP.   +3 more
europepmc   +1 more source

Smart Integration of Structural Biology and Medicinal Chemistry to Unlock Target‐Driven Drug Discovery

Medicinal Research Reviews, EarlyView.
ABSTRACT To enhance drug discovery efforts, medicinal chemists should evaluate, filter, and utilize relevant structural information about target proteins. Acquiring and interpreting protein structures is crucial for elucidating ligand‐receptor interactions and addressing ADME‐related considerations, making it an essential aspect of medicinal chemistry.
Matteo Rossi Sebastiano, Giulia Apprato, Serena Francisco, Giuseppe Ermondi, Giulia Caron   +4 more
wiley   +1 more source

Structures of nucleotide-bound Redondovirus Rep protein link conformation and function. [PDF]

PLoS Pathog
Montermoso S, Gupta K, Pumroy RA, Moiseenkova-Bell V, Bushman FD, Van Duyne GD.   +5 more
europepmc   +1 more source

Calcium signaling in plant defense

New Plant Protection, EarlyView.
Calcium signaling acts as a central hub in plant immunity, translating pathogen perception into defense responses. This review highlights the channels, sensors, and signaling networks involved, and discusses how pathogens subvert calcium dynamics, as well as how this knowledge may inspire innovative strategies for engineering durable crop resistance ...
Lifan Sun, Yu Wang, Jie Zhang
wiley   +1 more source

Investigation of the Mechanism of Cinnamaldehyde in Irritable Bowel Syndrome Based via Network Pharmacology, Molecular Docking, and Animal Experiments

Pediatric Discovery, EarlyView.
Through network pharmacology and molecular docking, it has been discovered that CA can target MAOB, among other proteins, to exert a therapeutic effect in IBS. In vivo, CA lowered visceral hypersensitivity, anxiety and depression‐like behaviors, and fecal water content, highlighting its therapeutic potential for IBS via anti‐inflammatory pathways ...
Qingyang Yu, Boqing Xu, Chunfang Dai, Yayan Pang, Zhifang Dong   +4 more
wiley   +1 more source

Phosphorylation of NLRP6 at Serine 27 site is critical for NLRP6 inflammasome activation and neurological impairment in ischemic stroke. [PDF]

Cell Commun Signal
Tan J, Wang M, Huang K, Xie M, Zheng Y, Luo J, Tang J, Zhai X, He Q, Zhao J.   +9 more
europepmc   +1 more source