Results 221 to 230 of about 201,093 (287)

Resolving oligomeric states of photoactivatable proteins in living cells via photon counting histogram analysis. [PDF]

iScience
Camp T, Li Z, Li Y, Oh TJ, Zhang K.
europepmc   +1 more source

6‐Shogaol Attenuates Doxorubicin‐Induced Cardiac and Skeletal Muscle Atrophy by Inhibiting E3 Ubiquitin Ligases and Necroptosis

Phytotherapy Research, EarlyView.
Doxorubicin induces cardiac and skeletal muscle atrophy by upregulating E3 ubiquitin ligases, inhibiting myogenic regulatory factors, and activating necroptosis. Cardiac atrophy can further exacerbate cardiotoxicity. 6‐Shogaol negatively regulates these processes and attenuates doxorubicin‐induced cardiac and skeletal muscle atrophy.
Xipeng Sun, Yaxian Wang, Quanjun Yang, Bo Xin, Jinlu Huang, Cheng Guo   +5 more
wiley   +1 more source

Cullin-3 adaptor SHKBP1 inhibits SQSTM1/p62 oligomerization and Keap1 sequestration. [PDF]

J Cell Biol
Luan L, Cao X, Xia Z, Vaid S, Leonetti MD, Baskin JM.   +5 more
europepmc   +1 more source

Xanthatin‐13‐(Pyrrolidine‐2‐Carboxylic Acid), a Sesquiterpene Lactone Isolated From Burdock Leaf, Attenuated Aβ25‐35 Toxicity and Memory Deficits in a Pharmacological Mouse Model of Alzheimer's Disease

Phytotherapy Research, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a severe form of dementia, which occurrence increases with age and lifestyle conditions. It is characterized by amyloid protein accumulation forming senile plaques, hyperphosphorylated tau protein forming neurofibrillary tangles, neuroinflammation, and oxidative stress, leading to synapse loss and cell death ...
Charlyne Barry‐Simonnet, Lucie Crouzier, Tristan Moujellil‐Legagneur, Hamza Chaieb‐Errass, Yanis A. Idres, Karine Ferrare, Marc Rolland, Guillaume Cazals, Patrick Poucheret, Tangui Maurice, Didier Tousch   +10 more
wiley   +1 more source

Effects of Hydration on Transthyretin Conformational Dynamics and Oligomerization. [PDF]

Biochemistry
Hampton J, Lantz C, Rider RL, Yun SD, Laganowsky A, Russell DH.   +5 more
europepmc   +1 more source

Supramolecular Assemblies of Self‐Immolative Janus Dendrimers With Rapid Photodegradation Response

Small, EarlyView.
Self‐immolative Janus dendrimers assemble into spherical nanoparticles with solid cores. Upon irradiation, rapid end‐to‐end depolymerization triggers a unique degradation pathway from spheres to crescents within minutes, enabling on‐demand release of encapsulated cargo.
Chuanfeng Li, Jiabin Luan, Daniela A. Wilson, Elizabeth R. Gillies   +3 more
wiley   +1 more source

NMR-based conformational analysis of DNA G-quadruplex guides mapping essential structure-function relationship in protein chaperoning.

Phys Chem Chem Phys
Negi D, Huang Z, Son A, Sathyamoorthy B, Horowitz S.   +4 more
europepmc   +1 more source

N-terminal oligomerization drives HDAC4 nuclear condensation and neurodevelopmental dysfunction in Drosophila. [PDF]

Open Biol
Hawley HR, Sutherland-Smith AJ, Savoian MS, Fitzsimons HL.   +3 more
europepmc   +1 more source

The Mechanism of NLRP3 Inflammasome Activation and Its Roles in Chronic Rhinosinusitis

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT NLRP3 (NLR family pyrin domain containing 3) is one of the crucial receptors in pathogen recognition receptor (PRR) families which can recognize the pathogen‐associated molecular patterns (PAMPs) and the damage‐associated molecular patterns (DAMPs), thus triggering innate immune response. After NLRP3 activation, it recruits the adaptor protein
Dong‐Lin Li, Yue Li, Yan‐Jie Jiang, Ge‐Hua Zhang, Li‐Hong Chang   +4 more
wiley   +1 more source