Results 231 to 240 of about 202,274 (300)

Upper and small bowel Crohn's disease in Brazilian children: Phenotypic characteristic and surgical risk

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Upper and small bowel Crohn's disease (U‐SBCD) represents a clinically aggressive phenotype with high complication rates yet remains diagnostically challenging. In low‐ and middle‐income countries (LMICs), limited inflammatory bowel disease (IBD) awareness contributes to diagnostic delays, but their impact on U‐SBCD outcomes remains
Jane Oba, Carlos Walter Sobrado, Elizete Aparecida Lomazi, Mariana Deboni, Michela Cynthia da Rocha Marmo, Vanessa Adriana Scheeffer, Silvio da Rocha Carvalho, Adérson Omar Mourão Cintra Damião, Matheus Freitas Cardoso de Azevedo, Carlos Frederico Sparapan Marques, Eytan Wine, Artur Figueiredo Delgado, Clovis Artur Almeida da Silva Full   +12 more
wiley   +1 more source

A Shock‐Tube Study of the HCl + M →$\to $ H + Cl + M (M = Ar) Rate Constant Using HCl Laser Absorption Near 3.3 µm

International Journal of Chemical Kinetics, EarlyView.
ABSTRACT Hydrogen chlorine (HCl) is an important combustion intermediate during plastic (municipal waste) and composite propellant (aerospace) combustion, but the understanding of its high‐temperature chemistry is still evolving. In this study, the pyrolysis of 0.5% HCl in Ar was investigated behind reflected shock waves in a shock tube at temperatures
Claire M. Grégoire, Olivier Mathieu, Eric L. Petersen   +2 more
wiley   +1 more source

High-Speed Atomic Force Microscopy Reveals Disordered Region-Mediated Structural Plasticity of Anaplastic Lymphoma Kinase Fusion Proteins Induced by Inhibitors. [PDF]

ACS Nano
Han X, Kodera N, Yilmaz N, Sakai K, Arai S, Li B, Imamura R, Voon DC, Fukuda K, Nanjo S, Flechsig H, Mano H, Matsumoto K, Yano S.   +13 more
europepmc   +1 more source

MiR‐145‐5p Attenuates Doxorubicin‐Induced Heart Injury Through Targeting Cardiomyocyte Pyroptosis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Doxorubicin (DOX), a potent anthracycline chemotherapeutic, exhibits dose‐dependent cardiotoxicity that limits its clinical utility. Although miR‐145‐5p demonstrates cardioprotective properties in cardiovascular diseases, its role in DOX‐induced cardiomyopathy remains undefined.
Xing‐Tao Chen, Yong‐Hong Yu, Yan‐Hua Du, Lin Xu, Xiang‐Ping Meng   +4 more
wiley   +1 more source

The GPR68-NINJ1 axis: an emerging mechano-chemical checkpoint in blood-brain barrier disruption-a hypothetical framework and therapeutic promise. [PDF]

Front Cell Neurosci
Bai B, Feng H, Yang H, Huang M, Wang Y.
europepmc   +1 more source

Molecular Mechanism of the IRF1/NFE2L1‐DT/ALKBH5/Cx43 Axis in Radiation‐Induced Injury in Vascular Endothelial Cells Through Pyroptosis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Radiotherapy effectively eradicates tumor cells but can also trigger pyroptotic damage in vascular endothelial cells. This study investigates the role of interferon regulatory factor 1 (IRF1) in radiation‐induced endothelial injury, aiming to provide mechanistic insights for optimizing radiotherapy.
Chen Li, Jia‐Wen Yang, Yong‐Rui Jia, Jie Zhang, Qiao Gou   +4 more
wiley   +1 more source

DNA Modulates Structural Transitions and Oligomerization Kinetics of the Functional Amyloid CRES. [PDF]

J Am Chem Soc
Kukreja R, Canny MD, Cornwall GA, Latham MP.   +3 more
europepmc   +1 more source

Zika NS2B Protein: In Vitro Formation of Large Multimeric Networks. [PDF]

Int J Mol Sci
Ponniah C, Surya W, Torres J.
europepmc   +1 more source

Structures of nucleotide-bound Redondovirus Rep protein link conformation and function. [PDF]

PLoS Pathog
Montermoso S, Gupta K, Pumroy RA, Moiseenkova-Bell V, Bushman FD, Van Duyne GD.   +5 more
europepmc   +1 more source

Experimental and Computational Simulation of the Prebiotic Peptide Bond Formation Driven by Wet-Dry Cycles and Gamma Ionizing Radiation: An Insight into Molecular Evolution. [PDF]

J Mol Evol
Fonseca-González E, Fuentes-Carreon CA, Heredia-Barbero A.   +2 more
europepmc   +1 more source