Results 71 to 80 of about 14,081 (169)

Ablative radiotherapy in castration‐resistant prostate cancer

BJU International, Volume 138, Issue 4, Page 659-665, October 2026.
Objective To prove the oncological benefit of ablative radiotherapy in patients with up to five metastases from castration‐resistant prostate cancer (CRPC) a single‐centre randomised trial was initiated. Patients and Methods This monocentric, randomised, phase II clinical trial enrolled patients with up to five prostate‐specific membrane antigen ...
Tobias Hölscher, Fabian Lohaus, Lydia Koi, Jörg Kotzerke, Sebastian Hoberück, Christian Thomas, Angelika Borkowetz, Steffen Löck, Mechthild Krause, Esther G.C. Troost   +9 more
wiley   +1 more source

Stereotactic body radiotherapy plus sunitinib vs. sunitinib alone in treatment-naive oligometastatic renal cell carcinoma: A phase 2 clinical trial

Cell Reports Medicine
Summary: Comparative data on stereotactic body radiotherapy (SBRT) in oligometastatic renal cell carcinoma (RCC) is lacking. This single-center, phase 2 non-randomized controlled trial enrolls patients with treatment-naive oligometastatic RCC.
Yang Liu, Xin-Yue Zhang, Wen-Su Wei, Rui-Qi Liu, Qi-Wen Pan, Yi-Jun Zhang, Ji-Bin Li, Yu-Lu Peng, Ting-Xuan Huang, Zhi-Ling Zhang, Hui Han, Sheng-Jie Guo, Jian-Ming Gao, Fang-Jian Zhou, Pei Dong, Li-Ru He   +15 more
doaj   +1 more source

Controversies in NEN: An ENETS position statement on the role of liver transplantation (LT) in patients with advanced small‐intestinal and pancreatic NETs

Journal of Neuroendocrinology, Volume 38, Issue 10, October 2026.
Abstract Liver transplantation (LT) may offer survival or symptomatic benefit for highly selected patients with advanced, well‐differentiated small‐intestinal or pancreatic neuroendocrine tumours and unresectable liver‐dominant metastases. However, its role remains controversial, as LT is rarely curative, recurrence is common, and benefits must be ...
Peter Stålberg, Mairéad G. McNamara, Simona Grozinsky‐Glasberg, Andreas Pascher, Beata Kos‐Kudla, Timm Denecke, Nehara Begum, Wendy Martin, Stephanie Alband, Clarisse Dromain, Raj Srirajaskanthan, Eric Baudin   +11 more
wiley   +1 more source

Prognostic impact of surgical resection after chemotherapy in oligometastatic versus non-oligometastatic gastric cancer

Background Surgical resection following chemotherapy has been considered a potentially effective strategy for improving survival in patients with stage IV gastric cancer. Recently, the concept of oligometastasis has gained increasing attention. However,
Yota Kawasaki, Daisuke Matsushita, Kenji Baba, Masahiro Noda, Takaaki Arigami, Takao Ohtsuka, Keishi Okubo, Masataka Shimonosono, Ken Sasaki   +8 more
core   +1 more source

Steering decision making by terminology : oligometastatic versus argometastatic

, 2022
: Allowing selected patients with few distant metastases to undergo potentially curative local ablation, the designation "oligometastatic" has become a widely popular concept in oncology.
Szturz, P., Vermorken, J.B., Vermorken, Jan Baptist, Szturz, Petr, Vermorken, Jan B.   +4 more
core   +1 more source

Usefulness of Stereotactic Body Radiation Therapy for Treatment of Adrenal Gland Metastases

Frontiers in Oncology, 2019
Purpose: This study aimed to describe our institutional experience in the use of stereotactic body radiation therapy (SBRT) for the management of adrenal gland metastases from multiple primary cancers.Materials and Methods: We retrospectively reviewed 31
Cyrielle Scouarnec, David Pasquier, Joel Luu, Florence le Tinier, Loïc Lebellec, Erwann Rault, Eric Lartigau, Xavier Mirabel   +7 more
doaj   +1 more source

Guidelines for Pediatric Radiotherapy Simulation: A Report From the Children's Oncology Group Radiation Oncology Discipline

Pediatric Blood &Cancer, Volume 73, Issue 9, September 2026.
ABSTRACT Pediatric radiation therapy presents unique challenges compared to adult treatments, including those of immobilization, potential need for sedation, and the critical importance of accurate, reproducible positioning. Additionally, heightened attention to imaging doses is necessary to minimize long‐term toxicity in survivors.
Parham Alaei, Stephen Mihalcik, Sujith Baliga, Young Kwok, Dana Casey, Eric Ehler, Christiane Burton, John C. Breneman, Daphne A. Haas‐Kogan, Suzanne L. Wolden, Arnold C. Paulino, Nadia N. Laack, Natia Esiashvili, Sarah Milgrom, Christine Hill‐Kayser, Thomas J. Fitzgerald, John A. Kalapurakal, Chia‐Ho Hua   +17 more
wiley   +1 more source

Radiation‐Induced Tumor‐Intrinsic LTβR N‐Glycosylation Suppresses Pyroptosis Through TRIM28‐Mediated PCBP2 SUMOylation to Promote Gastric Cancer Radioresistance

Advanced Science, Volume 13, Issue 51, 14 September 2026.
Radiotherapy triggers LTβR N‐glycosylation, enhancing its overall protein stability and nuclear retention. This accumulation drives TRIM28‐mediated PCBP2 SUMOylation, suppressing pyroptosis and conferring gastric cancer radioresistance. Therapeutically, a targeted nanoplatform (cRGD‐Lipo@EMD) effectively disrupts this regulatory axis, offering a highly
Weijie Zang, Yunlong Ji, Chunwang Zhou, Xiwen Li, Zhuang Lu, Guangze Zhang, Yu Chen, Wanjiang Xue, Yilin Hu   +8 more
wiley   +1 more source

Essential Updates 2024–2025: Surgical Strategy for Esophageal Cancer Toward a New Paradigm in the Era of Immunotherapy and Personalization

Annals of Gastroenterological Surgery, Volume 10, Issue 5, Page 1368-1381, September 2026.
This review summarizes key advances from 2024 to 2025 that are reshaping esophageal cancer surgery toward a strategy‐oriented, personalized paradigm through the integration of immunotherapy, population aging, and intelligent technologies. Adjuvant nivolumab after neoadjuvant chemoradiotherapy remains the only perioperative approach with durable benefit,
Shuichiro Oya, Koichi Yagi, Yoshifumi Baba   +2 more
wiley   +1 more source

Salvage prostate therapies for local pelvic recurrence after primary radiation for prostate cancer

BJUI Compass, Volume 7, Issue 9, September 2026.
Abstract Objectives The purpose of this study is to evaluate salvage treatment after primary radiation therapy (RT) for prostate cancer within our hospital system. Specifically, we aim to evaluate treatment patterns, oncologic outcomes and complications.
Jamie Michael, Kathryn Fink, Vivian Wan, Sai K. S. R. Kaushik, Clayton Neill, Yutai Li, Ridwan Alam, David J. VanderWeele, Shilajit Kundu, Ashley E. Ross   +9 more
wiley   +1 more source