Results 91 to 100 of about 506,562 (336)

Effective incorporation of 2'-O-methyl-oligoribonucleotides into liposomes and enhanced cell association through modification with thiocholesterol [PDF]

, 1992
Cholesterol was linked to 2'-O-methyl-oligoribonucleotides (2'-OMe-RNA) via a disulfide bond by reacting the 3'-(pyridyldithio)-modified 2'-OMe-RNA with thiocholesterol in dichloromethane-methanol solution.
Oberhauser, Berndt, Wagner, Ernst
core   +1 more source

A single amino acid substitution in the alpha 3 domain of an H-2 class I molecule abrogates reactivity with CTL. [PDF]

, 1987
We previously described a somatic cell expressing a variant H-2Dd molecule that did not serve as a target for alloreactive anti-Dd CTL. The mutant cell line had been isolated by its failure to express a serological epitope present on the H-2Dd alpha 3 ...
Bluestone, JA, Potter, TA, Rajan, TV
core   +2 more sources

Mixed‐Dimensional 0D‐DNA‐2D Heterostructures Beyond van der Waals: A DNA‐Templated Strategy for Optoelectronic Tunability

Advanced Functional Materials, EarlyView.
A two‐step DNA metallization process is presented for the modular assembly of metal sulfide nanoparticles (NPs) on MoS2, with nanoscale control over their separation and ability to concomitantly assemble different kind of NPs. This allowed to tailor the photoinduced electrical response of phototransistors to different wavelengths, according to the ...
Kai Chen, Haosen Miao, Stoichko Dimitrov, Matteo Palma   +3 more
wiley   +1 more source

A Visual Compendium of Principal Modifications within the Nucleic Acid Sugar Phosphate Backbone

Molecules
Nucleic acid chemistry is a huge research area that has received new impetus due to the recent explosive success of oligonucleotide therapy. In order for an oligonucleotide to become clinically effective, its monomeric parts are subjected to ...
Daria Novikova, Aleksandra Sagaidak, Svetlana Vorona, Vyacheslav Tribulovich   +3 more
doaj   +1 more source

Oligonucleotide–Palladacycle Conjugates as Splice-Correcting Agents

Molecules, 2019
2’-O-Methylribo phosphorothioate oligonucleotides incorporating cyclopalladated benzylamine conjugate groups at their 5’-termini have been prepared and their ability to hybridize with a designated target sequence was assessed by conventional ...
Madhuri Hande, Osama Saher, Karin E. Lundin, C. I. Edvard Smith, Rula Zain, Tuomas Lönnberg   +5 more
doaj   +1 more source

Au-Ag template stripped pattern for scanning probe investigations of DNA arrays produced by Dip Pen Nanolithography

, 2008
We report on DNA arrays produced by Dip Pen Nanolithography (DPN) on a novel Au-Ag micro patterned template stripped surface. DNA arrays have been investigated by atomic force microscopy (AFM) and scanning tunnelling microscopy (STM) showing that the ...
Alessandrini A., Blackstock J. J., Bustamante C., Davis J. J., Demers L. M., Demers L. M., DeRisi J., DeRisi J. L., Diebel J., Ginger D. S., Hartschuch A., Hegner M., Heller R. A., Hong S. H., Kim J. M., Lander E. S., Lee S., Legay G., Losic D., Lyubchenko Y. L., Patole S.N., Piner R. D., Rosi N. L., Rospigliosi A., Rozhok S., Salaita K., Salaita K., Schena M., Shapir E., Shapir E., Sinensky A. K., van Hal N. L. W., Vettiger P., Wagner P., Yu X., Zhou D. J., Zhou D. J.   +36 more
core   +1 more source

Application of COMPOCHIP Microarray to Investigate the Bacterial Communities of Different Composts [PDF]

, 2009
A microarray spotted with 369 different 16S rRNA gene probes specific to microorganisms involved in the degradation process of organic waste during composting was developed. The microarray was tested with pure cultures, and of the 30,258 individual probe-
A Alfreider, A Loy, A Loy, BEE Buchholz-Cleven, Brigitte A. Knapp, CJF Braak ter, D Guschin, D-Y Lee, DA Stahl, DM Barrett, EW Alm, F Schwieger, F Wintzingerode von, G Muyzer, G Taroncher-Oldenburg, G Varani, H Daims, H Sanguin, H Urakawa, HAJ Hoitink, HAJ Hoitink, HAJ Hoitink, Heribert Insam, HM Dionisi, IH Franke-Whittle, IH Franke-Whittle, Ingrid H. Franke-Whittle, J Peplies, J Ryckeboer, Jacques Fuchs, JG Fuchs, K Nakasaki, K-H Kim, KJ Breslauer, L Bodrossy, L Bodrossy, L Ludwig, M Blanc, M Danon, M Hogardt, MA Elorrieta, MT Suzuki, N Stralis-Pavese, P Legendre, P Schloss, PM Dees, R Amann, Ruediger Kaufmann, S Haruta, SF Altschul, SM Tiquia, SM Tiquia, T Beffa, W-T Liu, Y Koizumi   +54 more
core   +1 more source

Microbubble‐Controlled Delivery of Biofilm‐Targeting Nanoparticles to Treat MRSA Infection

Advanced Functional Materials, EarlyView.
Here, an effective strategy using microbubble (MB)‐controlled delivery of biofilm‐targeting nanoparticles (BTNs) for removal and therapy of methicillin‐resistant Staphylococcus aureus (MRSA) biofilm infections is introduced. In vivo delivery of MB with BTN is demonstrated to silence key bacterial genes involved in biofilm formation (icaA), bacterial ...
Ju Yeon Chung, Yujin Ahn, Joo Hun Lee, Seungju Yang, Seung Cheol Lee, Hyunjoon Kong, Hyun Jung Chung   +6 more
wiley   +1 more source

Antisense oligonucleotides and their applications in rare neurological diseases

Frontiers in Neuroscience
Rare diseases affect almost 500 million people globally, predominantly impacting children and often leading to significantly impaired quality of life and high treatment costs. While significant contributions have been made to develop effective treatments
Simon McDowall, Simon McDowall, May Aung-Htut, May Aung-Htut, Steve Wilton, Steve Wilton, Dunhui Li, Dunhui Li   +7 more
doaj   +1 more source

Targeting DMPK with Antisense Oligonucleotide Improves Muscle Strength in Myotonic Dystrophy Type 1 Mice

Molecular Therapy: Nucleic Acids, 2017
Myotonic dystrophy type 1 (DM1), a dominant hereditary muscular dystrophy, is caused by an abnormal expansion of a (CTG)n trinucleotide repeat in the 3′ UTR of the human dystrophia myotonica protein kinase (DMPK) gene.
Dominic Jauvin, Jessina Chrétien, Sanjay K. Pandey, Laurie Martineau, Lucille Revillod, Guillaume Bassez, Aline Lachon, A. Robert McLeod, Geneviève Gourdon, Thurman M. Wheeler, Charles A. Thornton, C. Frank Bennett, Jack Puymirat   +12 more
doaj   +1 more source