Results 91 to 100 of about 629,663 (337)

Antisense oligonucleotides and their applications in rare neurological diseases

Frontiers in Neuroscience
Rare diseases affect almost 500 million people globally, predominantly impacting children and often leading to significantly impaired quality of life and high treatment costs. While significant contributions have been made to develop effective treatments
Simon McDowall, Simon McDowall, May Aung-Htut, May Aung-Htut, Steve Wilton, Steve Wilton, Dunhui Li, Dunhui Li   +7 more
doaj   +1 more source

Synthesis and Properties of 2'-Deoxyuridine Analogues Bearing Various Azobenzene Derivatives at the C5 Position

Chemosensors, 2015
Nucleic acids that change their properties upon photo-irradiation could be powerful materials for molecular sensing with high spatiotemporal resolution.
Shohei Mori, Kunihiko Morihiro, Yuuya Kasahara, Shin-ichi Tsunoda, Satoshi Obika   +4 more
doaj   +1 more source

Negative regulation of the androgen receptor gene through a primate specific androgen response element present in the 5' UTR [PDF]

, 2014
Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
Hay, Colin W, Hunter, Irene, Lavery, Derek N, MacKenzie, Alasdair, McEwan, Iain J, Watt, Kate   +5 more
core   +2 more sources

SNUPN‐Related Muscular Dystrophy: Novel Phenotypic, Pathological and Functional Protein Insights

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SNUPN‐related muscular dystrophy or LGMDR29 is a new entity that covers from a congenital or childhood onset pure muscular dystrophy to more complex phenotypes combining neurodevelopmental features, cataracts, or spinocerebellar ataxia. So far, 12 different variants have been described.
Nuria Muelas, Pablo Iruzubieta, Alberto Damborenea, Laura Pérez‐Fernández, Inmaculada Azorín, Juan Carlos Jiménez García, Ana Töpf, Pilar Martí, Lorena Fores‐Toribio, María Manterola, Rosana Blanco‐Mañez, Oihane Pikatza‐Menoio, Sonia Alonso‐Martín, Volker Straub, Aitziber L. Cortajarena, Adolfo López de Munain, David De Sancho, Lorea Blázquez, Juan J. Vilchez   +18 more
wiley   +1 more source

Interaction of yeast eIF4G with spliceosome components Implications in pre-mRNA processing events [PDF]

, 2009
International audienceAs evidenced from mammalian cells the eukaryotic translation initiation factor eIF4G has a putative role in nuclear RNA metabolism. Here we investigate whether this role is conserved in the yeast Saccharomyces cerevisiae.
Barrass, J. David, Beggs, Jean D., Fromont-Racine, Micheline, Jacquier, Alain, Kafasla, Panagiota, Lewis, Joe, Thompson, Elizabeth   +6 more
core   +2 more sources

Mixed‐Dimensional 0D‐DNA‐2D Heterostructures Beyond van der Waals: A DNA‐Templated Strategy for Optoelectronic Tunability

Advanced Functional Materials, EarlyView.
A two‐step DNA metallization process is presented for the modular assembly of metal sulfide nanoparticles (NPs) on MoS2, with nanoscale control over their separation and ability to concomitantly assemble different kind of NPs. This allowed to tailor the photoinduced electrical response of phototransistors to different wavelengths, according to the ...
Kai Chen, Haosen Miao, Stoichko Dimitrov, Matteo Palma   +3 more
wiley   +1 more source

Batch-Learning Self-Organizing Map Identifies Horizontal Gene Transfer Candidates and Their Origins in Entire Genomes

Frontiers in Microbiology, 2020
Horizontal gene transfer (HGT) has been widely suggested to play a critical role in the environmental adaptation of microbes; however, the number and origin of the genes in microbial genomes obtained through HGT remain unknown as the frequency of ...
Takashi Abe, Yu Akazawa, Atsushi Toyoda, Atsushi Toyoda, Hironori Niki, Tomoya Baba, Tomoya Baba   +6 more
doaj   +1 more source

Systems Biology and the Development of Vaccines and Drugs for Malaria Treatments [PDF]

, 2006
The sequencing race has ended and the functional race has already begun. Microarray technology enables simultaneous gene expression analysis of thousands of genes, enabling a snapshot of an organisms’ transcriptome at an unprecedented resolution.
Adebiyi, E. F.
core   +1 more source

Error, reproducibility and sensitivity : a pipeline for data processing of Agilent oligonucleotide expression arrays [PDF]

, 2010
Background Expression microarrays are increasingly used to obtain large scale transcriptomic information on a wide range of biological samples. Nevertheless, there is still much debate on the best ways to process data, to design experiments and analyse ...
AR Dabney, AR Dabney, Benjamin Chain, BM Bolstad, BP Durbin, BS Everitt, CR Hampton, D Wang, E Birney, Helen Bowen, J Fan, J Rasaiyaah, J Rasaiyaah, Jane Rasaiyaah, Jhen Tsang, John Hammond, JP Hammond, L Shi, M Noursadeghi, M Sultan, Mahdad Noursadeghi, MN McCall, PA 't Hoen, TA Patterson, TC Kroll, WE Johnson, Wilfried Posch   +26 more
core   +2 more sources

A Sustainable Biotechnology Approach for Mineral Separation

Advanced Functional Materials, EarlyView.
Silver‑binding peptides are first identified through phage‐display screening, and then engineered into multifunctional and responsive peptides or proteins. These tailored biomolecules can selectively capture and aggregate silver particles or ions from complex mixtures, enabling rapid and efficient silver separation and recovery.
Guangze Yang, Yun Liu, Shankar Raj Devkota, Yue Hui, Ruilin Zhao, Yang Li, David A. Weitz, Chun‐Xia Zhao   +7 more
wiley   +1 more source