Results 171 to 180 of about 523,140 (287)

On the mechanism of oligonucleotide-primed RNA synthesis.I. Model studies with deoxy-homopolymer templates and Escherichia coli RNA polymerase [PDF]

, 1977
Coen F. van Kreijl, R.H.J. Beelen, Piet Borst   +2 more
openalex   +1 more source

Dynein‐Dependent Endo‐Lysosomal Degradation Drives Lewy Body Disorders Accompanied by Aβ Pathology

Advanced Science, EarlyView.
This study investigates the impact of Aβ plaques on α‐synuclein (αSyn) pathologies in dementia with Lewy bodies (DLB). Co‐culturing primary neurons with AD mouse brain slices reveals impaired dynein‐dependent organelle trafficking, affecting αSyn degradation. Activating Rab7 restores this process, reducing αSyn inclusions.
Linlin Zhou, Yuwei Wang, Yu Liu, Feipeng Zhu, Ge Gao, Chengjie Li, Pu Ai, Jingying Xu, Junxin Wang, Long Guo, Yuting Guan, Virginia Man‐Yee Lee, Jianjun Chen, Jialin Zheng, Qihui Wu   +14 more
wiley   +1 more source

Synthesis of large single-transcript pathways from oligonucleotide pools: Design of STARBURST, an autobioluminescent reporter. [PDF]

Proc Natl Acad Sci U S A
Dvir G, Xing Z, Beldman I, Rivera A, Wheeldon I, Cutler SR.   +5 more
europepmc   +1 more source

Occurrence of Uridylate-Rich Oligonucleotide Regions in Heterogeneous Nuclear RNA of HeLa Cells

, 1972
George R. Molloy, William Thomas, James Darnell   +2 more
openalex   +1 more source

Oligonucleotide inhibitor of protein synthesis made in extracts of interferon-treated chick embryo cells: Comparison with the mouse low molecular weight inhibitor [PDF]

, 1978
L. Andrew Ball, Carol N. White
openalex   +1 more source

An Antagonism Between Ethylene Signaling and DNA Methylation Orchestrates the Progression of Leaf Senescence in Non‐heading Chinese Cabbage

Advanced Science, EarlyView.
CMT2 mediates the maintenance of DNA methylation on the promoters of SAGs, thereby inhibiting EIN3A untimely activating SAGs’ expression. Aging‐impelled striking upregulation of EIN3A strongly suppresses the expression of CMT2 to reduce the methylation level, which releases the activation of EIN3A on SAGs, thus initiating and accelerating the ...
Dingyu Zhang, Yong Luo, Han Wang, Xiaofeng Li, Liming Miao, Lu Gao, Haibo Hao, Xinman Wang, Benke Kuai, Hongfang Zhu, Guodong Ren   +10 more
wiley   +1 more source

Editorial: Recent trends and spotlight on nucleotide-based drugs: novel targets, their design, delivery, and clinical potential

Frontiers in Pharmacology, 2023
Subhash Chander, Shvetank Bhatt, Kamal Dua, Kamal Dua, Kamal Dua, Hemant Jadhav   +5 more
doaj   +1 more source

HR-MS Analysis of the Covalent Binding of Edaravone to 5-Formylpyrimidine Bases and a DNA Oligonucleotide Containing a 5-Formylcytidine Residue. [PDF]

Rapid Commun Mass Spectrom
Regnault R, Kouach M, Goossens L, Thuru X, Bailly C, Goossens JF.   +5 more
europepmc   +1 more source

A computer aided oligonucleotide analysis provides a model sequence for RNA polymerase-promoter recognition in E.coli [PDF]

, 1978
Günther E.F. Scherer, Malcolm D. Walkinshaw, Struther Arnott   +2 more
openalex   +1 more source

Listerin Alleviates Alzheimer's Disease through IRE1‐mediated Decay of TLR4 mRNA

Advanced Science, EarlyView.
Alzheimer's disease (AD) progression is influenced by microglia‐mediated neuroinflammation. Here, it is demonstrated that Listerin suppresses neuroinflammatory signaling and cognitive impairment in AD models by triggering IRE1α‐mediated TLR4 mRNA decay. Adenoviral Listerin delivery reduces amyloid‐β pathology, positioning it as a new therapeutic target.
Fei Qin, Runyu Cao, Xuemei Bai, Jiahua Yuan, Wanwei Sun, Yi Zheng, Xiaopeng Qi, Wei Zhao, Bingyu Liu, Chengjiang Gao   +9 more
wiley   +1 more source