Results 181 to 190 of about 631,547 (339)

Effect of Cibacron blue F3GA on oligonucleotide binding site of estradiol--receptor complexes of mouse uterine cytosol.

, 1979
S. Anand Kumar, Thaisa A. Beach, Herbert W. Dickerman   +2 more
openalex   +1 more source

Single‐Cell Transcriptome Analysis Reveals That Hmga2 Regulates Neuroinflammation and Retinal Function by Modulating Müller Cell Autophagy Through PI3K/AKT Signaling Following MCAO‐Induced Retinal Ischemia

Advanced Science, EarlyView.
Employing snRNA‐seq post‐MCAO‐induced retinal ischemia (RI), this study revealed a novel Hmga2‐high Müller cell subpopulation. Hmga2 knockout alleviated neuroinflammation and RI symptoms, potentially by binding PI3K and regulating Müller cell autophagy.
Weihao Lv, Juzheng Yuan, Zhe Ruan, Ya‐nan Dou, Hongchen Zhang, Xiaowei Fei, Leiying Chen, Zehan Zhang, Kai Yang, Xiuquan Wu, Zhou Fei, Fei Fei   +11 more
wiley   +1 more source

Discovery of a Potent and Selective TEAD Degrader with Durable Degradation Activity

Advanced Science, EarlyView.
KG‐FP‐003, a highly potent TEAD‐YAP PROTAC derived from the patented inhibitor is developed. It selectively degrades endogenous TEAD proteins in HiBiT systems without IMiD‐related off‐target effects. Screening across 867 cancer cell lines revealed broad and superior anti‐tumor activity, highlighting its therapeutic potential through targeted TEAD ...
Linhui Cao, Jing Yang, Yuhang Liu, Xiaotong Chen, Yufang Shi, Yunshuo Zhao, Yong Zhang, Jian Chen, Bowen Li, Wuqiang Wen, Lu Chen, Bo Peng, Lu Huang, Yanli Sun, Lixin Zhou, Matthew G Rees, Melissa M Ronan, Jennifer A Roth, Zhixiang Guo, Jing Xing, Guangya Zhu, Yazhou Wang, Baishan Jiang, Jing Lu, Kehao Zhao, Wenchao Lu   +25 more
wiley   +1 more source

Differential stability and dynamics of DNA-based and RNA-based coacervates affect non-enzymatic RNA chemistry. [PDF]

Nat Commun
Nakashima KK, Mihoubi FZ, Saraya JS, Russell KO, Rahmatova F, Robinson JD, Maristany MJ, Huertas J, Rubio-Sánchez R, Collepardo-Guevara R, O'Flaherty DK, Bonfio C.   +11 more
europepmc   +1 more source

Strategic Design of Aptamer‐Guided Aggregation‐Induced Emission Nanoparticles for Targeted Photodynamic Therapy in Breast Cancer

Advanced Science, EarlyView.
This study presents MF3Ec‐TBPP nanoparticles for targeted photodynamic therapy of Luminal A breast cancer. These nanoparticles combine an AIE‐based photosensitizer with an aptamer. Tests show they effectively inhibit tumor growth while protecting healthy tissue via aggregation and dipalmitoylphosphatidylcholine, indicating potential for improved ...
Charlie C. H. Ma, Qingqing Liu, Yue Sui, Wutong Du, Kristy W. K. Lam, Jacky W. Y. Lam, Chao Li, Tengteng Chen, Jianwei Sun, Nuomin Li, Ryan T. K. Kwok, Jianping Chen, Feiyi Sun, Ben Zhong Tang   +13 more
wiley   +1 more source

General Approach for the Synthesis of Triazinyl Phosphoramidate Oligonucleotides via the Staudinger Reaction with the Use of 2‑Azido-4,6-dichloro-1,3,5-triazine. [PDF]

ACS Omega
Zharkov TD, Kupryushkin MS.
europepmc   +1 more source

Studies on transfer ribonucleic acids and related compounds. IX⁽¹⁾Ribo-oligonucleotide synthesis using a photosensitive o-nitrobenzyl protection at the 2′-hydroxyl group [PDF]

, 1974
Eiko Ohtsuka, Satoshi Tanaka, Morio Ikehara   +2 more
openalex   +1 more source

Arabidopsis TRB Proteins Form Two Closely Related Complexes to Mediate H3K4me3 Demethylation and Transcriptional Repression

Advanced Science, EarlyView.
This study reveals that Arabidopsis telomere repeat binding proteins (TRBs) form two closely related complexes. These complexes mediate H3K4me3 demethylation and transcriptional repression through a positive feedback loop and cooperate with PEAT and PRC2 complexes to regulate multiple histone modifications and gene expression across the genome ...
Qi Wang, Dan‐Yang Yuan, Yu‐Jia Lu, Xin Wang, Hao Zheng, Lin Li, She Chen, Xin‐Jian He   +7 more
wiley   +1 more source

Thymidine-Inosine Dimer Building Block for Reversible Modification of Synthetic Oligonucleotides. [PDF]

Molecules
Kolganova NA, Varizhuk IV, Stomakhin AA, Khisamov MM, Solyev PN, Surzhikov SA, Timofeev EN.   +6 more
europepmc   +1 more source

Oligonucleotide mapping of non-radioactive virus and messenger RNAs [PDF]

, 1977
David Frisby
openalex   +1 more source