Results 191 to 200 of about 631,547 (339)

Anticodon Engineered Transfer RNA (tRNASUAG) Inhibits Hepatitis B Virus Replication by Promoting the Degradation of Core Protein

Advanced Science, EarlyView.
This study employed tRNASUAG, an anticodon‐engineered tRNA (ACE‐tRNA), to introduce a phosphorylatable serine into the C‐terminal domain of HBc by reading through its stop codon, thereby potentially promoting the ubiquitin‐proteasome degradation of HBc, and subsequently inhibiting HBV replication. Through a tRNASUAG‐gHBV1‐tRNASUAG‐gHBV2‐tRNASUAG tandem
Xingwen Yang, Huiying Sun, Ziheng Luo, Qinxin Zhang, Yarong Song, Jie Li, Xiaoyun Liu, Jie Wang   +7 more
wiley   +1 more source

Antisense Oligonucleotide Therapy for Amyotrophic Lateral Sclerosis (ALS): An Umbrella Review. [PDF]

Cureus
Jeong E, Li D.
europepmc   +1 more source

Transcription of single base oligonucleotides by ribonucleic acid-directed deoxyribonucleic acid polymerase [PDF]

, 1976
A.K. Falvey, Gary B. Weiss, Leslie J. Krueger, Judy Kantor, W. French Anderson   +4 more
openalex   +1 more source

Single Cell and Spatial Transcriptomics Define a Proinflammatory and Profibrotic Niche After Kidney Injury

Advanced Science, EarlyView.
By integrating single‐cell RNA sequencing and spatial transcriptomics, tenascin C (TNC) is unveiled as a central organizer of the proinflammatory and profibrotic niche in kidney fibrosis. TNC promotes macrophage activation through TLR4/NF‐κB signaling, leading to renal inflammation and fibrosis.
Li Li, Jinlin Liao, Yuxi Zhang, Zifu Yao, Junxin Huang, Kejia Wu, Lu Li, Yiling Peng, Haili Zhu, Xue Hong, Xi Liu, Lili Zhou, Fan Fan Hou, Haiyan Fu, Youhua Liu   +14 more
wiley   +1 more source

Peptide-mediated Cell and In Vivo Delivery of Antisense Oligonucleotides and siRNA

Molecular Therapy: Nucleic Acids, 2012
Peter Järver, Thibault Coursindel, Samir EL Andaloussi, Caroline Godfrey, Matthew JA Wood, Michael J Gait   +5 more
doaj   +1 more source

Immunoregulatory properties of cell free DNA. [PDF]

Cell Mol Life Sci
Ferrera F, Altosole T, Tardito S, Astone G, Bernardi C, Parodi A, Marini C, Conteduca G, Cichero E, Salis A, Arpesella L, Camporesi L, Lagazio A, Rigo V, Pigozzo A, Damonte G, Fossa P, Fenoglio D, De Palma R, Inghirami G, Filaci G.   +20 more
europepmc   +1 more source

Tackling Allergic Airway Inflammation with Organic Sheet‐Like Nanoplatforms by Targeted Elimination of Epithelial Small Extracellular Vesicles

Advanced Science, EarlyView.
In this work, “inorganic‐free” nanosheets, named PNSE are developed using template‐based synthesis technology. The functionalized organic nanosheets exhibit low cytotoxicity, mild protein adsorption, and potent binding efficacy to epithelial sEVs.
Zhaoxu Tu, Junyan Lin, Zhixin Li, Yuefei Zhu, Changyi Xu, Zihan Qiu, Qiumin Wang, Yang Ye, Yihui Wen, Jian Li, Kam W. Leong, Weiping Wen   +11 more
wiley   +1 more source

Translational and clinical development of therapeutic siRNA and ASOs: current industry practices, perspectives, and recommendations. [PDF]

Nucleic Acids Res
Christensen JK, Colletti N, Hooshfar S, Jiang RR, Kuo C, Lindmark B, Lumen A, Youssef AS, Albertolle M, Aluri KC, Chen L, Chen J, Chopda G, Chua XY, Morais P, Dubois B, Gibbons FF, Gudey SK, Gupta S, Hood S, Humphreys S, Husser C, Huth F, Jani D, Jian W, Kakuda T, Kurz J, Linnebjerg H, Liu J, Lohmann S, Niu T, Root K, Singla S, Tang C, Veluri R, Zhang GS, Zhang S, Jawa V.   +37 more
europepmc   +1 more source

On the Phe-tRNA induced binding of fluorescent oligonucleotides to the ribosomal decoding site [PDF]

, 1977
Heinrich M. Menzel
openalex   +1 more source

AGAPIR: A Novel PIWI‐Interacting RNA Enhancing Post‐Decompression Angiogenesis in Degenerative Cervical Myelopathy

Advanced Science, EarlyView.
The restoration of blood flow following surgical decompression for degenerative cervical myelopathy (DCM) significantly contributes to the amelioration of neurological deficits. This study identifies AGAPIR, an angiogenesis‐associated PIWI‐interacting RNA, enhances angiogenesis and motor function recovery post‐spinal cord decompression in a mouse model
Yongheng Xie, Yiling Peng, Tianyu Qin, Cuimei Chen, Zhenxiao Ren, Naibo Feng, Chungeng Liu, Songlin Peng, Houqing Long   +8 more
wiley   +1 more source