Results 211 to 220 of about 523,140 (287)

Endonuclease Mval dimerization induced by the oligonucleotide substrate [PDF]

, 1988
L. G. Ovechkina, S. R. Popova, V. V. Zinoviev, Donatas Vaitkevićius, A. Janulaitis, Yu. A. Gorbunov, E. G. Malygin   +6 more
openalex   +1 more source

PTf‐SRiApt Targeting SCAF4‐POLR2A Interaction Suppresses Tumor Growth and Promotes Antitumor Immunity in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
A phosphorothioate‐modified aptamer PTf‐SRiApt capable of disrupting “undruggable” transcription factor SCAF4‐POLR2A interaction with high inhibitory activity and biological stability is presented here. Through this inhibition, PTf‐SRiApt successfully arrested cell cycle progression, induced cell death, and elevated immune recruitment in SCAF4‐POLR2A ...
Liyan Fei, Yichun Pan, Jie Zhai, Tongqing Li, Yuxin Zhou, Sheyu Zhang, Juan Wei, Qian Hu, Xueying Liu, Lu Guo, Weizhu Wu, Yong Wei, Qin Wu, Weihong Tan   +13 more
wiley   +1 more source

Towards improved anticancer properties of the G-quadruplex-forming T40231 aptamer through increased flexibility of nucleoside residues. [PDF]

Sci Rep
Kotkowiak W, Bartyś N, Pasternak A.
europepmc   +1 more source

Catalytic Hairpin Assembly‐Propelled Weak‐Inputs‐Strong‐Outputs (CP‐WISO) DNA Logic Nanodevices with Orthogonal Design and Contrary Logic Responses

Advanced Science, EarlyView.
Catalytic hairpin assembly‐propelled weak‐inputs‐strong‐outputs (CP‐WISO) DNA logic nanodevices with orthogonal design and contrary logic responses are innovatively fabricated. Moreover, the even and odd parity generators/checkers for ensuring normal molecular data transmission, and the logic‐programmed miRNA biosensors with ratiometric fluorescent ...
Xujuan Lv, Jiawen Han, Juan Wang, Zhihua Lv, Baojian Huang, Shuai Qin, Xuxin Yan, Shaojun Dong, Daoqing Fan   +8 more
wiley   +1 more source

Cross-species translational modelling of targeted therapeutic oligonucleotides using physiologically based pharmacokinetics. [PDF]

J Pharmacokinet Pharmacodyn
Derbalah A, Stader F, Liu C, Zyla A, Abdulla T, Wu Q, Jamei M, Gardner I, Sepp A.   +8 more
europepmc   +1 more source

Analysis of nuclear factor I binding to DNA using degenerate oligonucleotides [PDF]

, 1986
Richard M. Gronostajski
openalex   +1 more source

Iron Oxide Nanoparticles Modified with Galloylated DNA for Magnetically Enhanced DNA‐Directed Assembly

Advanced Science, EarlyView.
A simple one‐step method is presented for DNA functionalization of iron oxide nanoparticles (IONP) using multidentate galloylated DNA. The DNA‐modified IONPs exhibit unique DNA binding properties of magnetically enhanced DNA interconnects. This study underscores the importance of nanoparticle (NP) effects in DNA sequence design and highlights the ...
Murali Golla, Hyunjin Jeon, Shine K. Albert, Hojun Lee, Seulki Kang, Moon Jeong Park, So‐Jung Park   +6 more
wiley   +1 more source

Split-and-pool synthesis to generate scalable combinatorial oligonucleotide libraries on magnetic nanoparticles. [PDF]

STAR Protoc
Nguyen JVL, Malic L, Nassif C, Da Fonte D, Tabrizian M.   +4 more
europepmc   +1 more source

A MXene‐Based Nanothermal Knife Inhibits Aggresome‐Mediated Persister Formation for Preventing Dental Caries

Advanced Science, EarlyView.
Early childhood caries (ECC) involves cariogenic persisters that evade antimicrobial treatment. Persisters achieve this by downregulating heat shock proteins (HSPs) and formation of protein aggregates. Ti3C2 MXene‐based photothermal therapy (PTT) acts as a “nanothermal knife,” disrupting membranes, upregulating HSPs, inhibits aggregates, prevents ...
Yinyin Zhang, Leilei Yang, Jing jiao, Wenshuai Li, Sen Lin, Xianlong Zong, Haoyang Qin, Danfeng Liu, Rui Li   +8 more
wiley   +1 more source

Targeting miR-32-5p suppresses c-MYC-driven proliferation and induces apoptosis in MCF-7 breast cancer cells. [PDF]

Med Oncol
Khoder AI, El-Sayed IH, Ali YBM.
europepmc   +1 more source