Results 211 to 220 of about 641,320 (378)

Commentary on aptamers for virus research

open access: yesFrontiers in Microbiology, 2012
Yasuyuki eMiyazaki, Mikako eFujita
doaj   +1 more source

Bacteriophage‐Mimetic DNA Origami Needle for Targeted Membrane Penetration and Cytosolic Cargo Delivery

open access: yesAdvanced Science, EarlyView.
We designed a synthetic DNA origami needle‐like structure inspired by bacteriophages for targeted drug delivery. Functionalized with trastuzumab antibodies, cholesterol, and dyes, it selectively targets SKBR3 cancer cells. A glutathione‐triggered dye payload enables controlled release, and delivery is verified using confocal microscopy and live cell ...
Anirban Samanta   +7 more
wiley   +1 more source

The Influence of the Capping Step During Solid-Phase Phosphoramidite Synthesis of Oligonucleotides on Synthetic Errors in Oligonucleotides. [PDF]

open access: yesMolecules
Yakovleva KI   +7 more
europepmc   +1 more source

Cleavage‐Resistant CYLD Protects Against Autoimmune Hepatitis

open access: yesAdvanced Science, EarlyView.
Proteolytic cleavage of the deubiquitinase CYLD emerges as a critical driver of autoimmune hepatitis. TNFα‐induced CYLD loss in macrophages amplifies S100A9‐triggered MAPK activation, leading to excessive chemokine production and hepatic inflammation. Pharmacological inhibition of MEK signaling effectively attenuates experimental disease, highlighting ...
Han Liu   +13 more
wiley   +1 more source

Systemic peptide-mediated oligonucleotide therapy improves long-term survival in spinal muscular atrophy

open access: yesProceedings of the National Academy of Sciences of the United States of America, 2016
S. Hammond   +11 more
semanticscholar   +1 more source

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