Results 291 to 300 of about 631,547 (339)

Globotriaosylceramide Gb3 Influences Wound Healing and Scar Formation by Orchestrating Fibroblast Heterogeneity

Advanced Science, EarlyView.
In superficial second‐degree burn wounds, Gb3 turns on genes related to papillary cells through the FGF2 signaling pathway. This increases the ability of cells to break down fibrin and decreases fibrosis, which ultimately prevents scar formation in burn injuries.
Sujie Xie, Runzhi Huang, Weijin Qian, Xinran Ding, Wei Zhang, Yixu Li, Jianyu Lu, Hanlin Sun, Yifan Liu, Yuntao Yao, Bingnan Lu, Minjuan Wu, Zhaofan Xia, Shizhao Ji   +13 more
wiley   +1 more source

Derivatization of Solid Supports Using a Carbamate-Linked Tether Containing a Disulfide Functional Group. [PDF]

Curr Protoc
Saraya JS, O'Flaherty DK.
europepmc   +1 more source

Hypoxia‐Induced PRMT1 Lactylation Drives Vimentin Arginine Asymmetric Dimethylation in Tumor Metastasis

Advanced Science, EarlyView.
Hypoxia triggers lactylation of PRMT1 at K134/K145, enhancing its methyltransferase activity to asymmetrically dimethylate vimentin R64. This post‐translational cascade promotes vimentin filament assembly, cytoskeletal remodeling, and tumor metastasis, with PRMT1 inhibition (MS023) reducing metastatic colonization.
Jia Zhou, Shuying Qiu, Xia Yang, Yan Wu, Xinxia Yao, Hangqi Hu, Jingfeng Luo, Chandra Sugiarto Wijaya, Lingfeng Ma, Xiaojun Long, Lingna Xu, Jinquan Liu, Chaoqun Wang, Yibin Pan, Xiaona Chen, Hongchuan Jin, Xian Wang   +16 more
wiley   +1 more source

Validation of diverse and previously untraceable Sendai virus copyback viral genomes by direct RNA sequencing. [PDF]

J Virol
Pye SE, Achouri E, Yang Y, Musa A, López CB.   +4 more
europepmc   +1 more source

An Aptamer‐Based EXACT Anticoagulant as a Sustainable, Animal‐Free Alternative to Unfractionated Heparin

Advanced Science, EarlyView.
By simply conjugating thrombin's active‐site inhibitor, dabigatran, with an exosite inhibitor, aptamer HD1, the resulting EXosite‐ACTive site (EXACT) inhibitors show two orders of magnitude higher potency and selectivity via synergistic binding, while maintaining the aptamer's antidote‐reversible trait, yielding a potential substitute for the animal ...
Haixiang Yu, George Pitoc, Manqi Zhang, Jeffrey Clancy, James Frederiksen, Amy Yan, Samuel Francis, Rebecca Sullenger, Rachel Rempel, Susannah Gammell, Jillian Caiazzi, Bruce A. Sullenger   +11 more
wiley   +1 more source

All-in-one Biocomputing Nanoagents with Multilayered Transformable Architecture based on DNA Interfaces. [PDF]

Theranostics
Cherkasov VR, Mochalova EN, Babenyshev AV, Nikitin MP.   +3 more
europepmc   +1 more source

Widespread tissue delivery of antagomiRs via intramuscular administration. [PDF]

Mol Ther Methods Clin Dev
Messios C, Koutsoulidou A, Phylactou LA.
europepmc   +1 more source

Potentially prebiotic isocyanide activation chemistry drives RNA assembly.

Chem Commun (Camb)
Zhang SJ, Jia X, DasGupta S, Szostak JW.
europepmc   +1 more source

Gene expression silencing therapy in tumors, focus on gastrointestinal and genitourinary tumors. [PDF]

Front Immunol
El-Ghazzi N, Italiano A, Angeli E.
europepmc   +1 more source

Integrating genetic testing into management of all patients with amyotrophic lateral sclerosis: a critical juncture. [PDF]

CMAJ
Breiner A, Schellenberg KL, Shoesmith C.
europepmc   +1 more source