Results 291 to 300 of about 641,320 (378)

General Approach for the Synthesis of Triazinyl Phosphoramidate Oligonucleotides via the Staudinger Reaction with the Use of 2‑Azido-4,6-dichloro-1,3,5-triazine. [PDF]

ACS Omega
Zharkov TD, Kupryushkin MS.
europepmc   +1 more source

OCTN2 Activates a Non‐Canonical Carnitine Metabolic Pathway to Promote MASH‐HCC Progression and Immunotherapy Resistance

Advanced Science, EarlyView.
In non‐MASH‐HCC, L‐carnitine promotes tumor progression primarily through its classical role in enhancing fatty acid oxidation (FAO). However, in MASH‐HCC, where FAO is markedly suppressed, L‐carnitine shifts from this canonical function to serve instead as an intracellular acetyl group buffer.
Chuqi Xia, Xiao Zhang, Jinze Li, Ning Xu, Sheng Hu, Qiyu Lu, Yuxuan Li, Taifu Xiao, Xu Li, Xue Wang, Kequan Xu, Daoming Liang   +11 more
wiley   +1 more source

The role of exosomes as oligonucleotide delivery system for managing α-synuclein in Parkinson's disease: A systematic review of <i>in vivo</i> studies. [PDF]

Mol Ther Nucleic Acids
Salarpour S, Dourandish F, Salajegheh A, Hashemi S.   +3 more
europepmc   +1 more source

Oligonucleotides used for quantitative real-time PCR.

Ayaka Watanabe (22057715), Shoshiro Hirayama (776671), Itsuki Kominato (22057718), Sybille Marchese (22057721), Pietro Esposito (11932931), Vanya Metodieva (19286361), Taeko Kimura (538348), Hiroshi Kameda (11337612), Terunori Sano (19142317), Masaki Takao (754166), Sho Takatori (1734199), Masato Koike (209042), Juan Alberto Varela (22057724), Taisuke Tomita (410925), Shigeo Murata (462393)   +14 more
openalex   +1 more source

Quantitative Assessment of Randomized DNA Base Sequences Using Multi‐Model Physical Analysis for High‐Fidelity Data Storage

Advanced Science, EarlyView.
This study quantitatively evaluates randomized DNA sequence design for digital data storage using three physics‐based models. By applying encoding schemes with strict homopolymer constraints, the framework improves base randomness, GC balance, and error resilience. Experimental validation via PCR and Sanger sequencing confirms 95–98% decoding accuracy,
Seongjun Seo, Thi Hong Nhung Vu, Anshula Tandon, Suyoun Park, Thi Bich Ngoc Nguyen, Shinsuke Kawai, Sung Ha Park   +6 more
wiley   +1 more source

Chemotherapeutic Spherical Nucleic Acids. [PDF]

ACS Nano
Luo T, Kim YJ, Han Z, Hwang J, Kumari S, Mayer V, Cushing A, Romero RA, Mirkin CA.   +8 more
europepmc   +1 more source

Smart Nanoparticles Disrupting Energy Supply through Triple Mechanisms to Kill Tumors via Dual Disruption of Mitochondria and Lysosomes

Advanced Science, EarlyView.
This study introduces a biomimetic nanoplatform (MTCA@C) designed for precise cancer therapy. It targets mitochondria to induce dysfunction through photodynamic activation, while concurrently blocking mitophagy via lysosomal alkalinization. The platform further triggers methuosis, resulting in tumor cell death through vacuolization and energy pathway ...
Xiao Xu, Qiqing Huang, Yang Liu, Jinzhuo Liu, Deyi Yang, Yanni Song, Xin Han   +6 more
wiley   +1 more source

CertPrime: a new oligonucleotide design tool for gene synthesis. [PDF]

Comput Struct Biotechnol J
Luna-Cerralbo D, Serrano A, Blasco-Machín I, Hamdan F, Martínez-Oliván J, Broset E, Bruscolini P.   +6 more
europepmc   +1 more source