Results 301 to 310 of about 635,743 (331)
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Trends in Biotechnology, 1992
Recent studies have focused on the ability of oligonucleotides to affect the genetic processes of many organisms, including viruses. Hence, oligonucleotides may represent a future source of biotechnologically derived compounds of therapeutic importance for diseases such as cancer and AIDS.
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Recent studies have focused on the ability of oligonucleotides to affect the genetic processes of many organisms, including viruses. Hence, oligonucleotides may represent a future source of biotechnologically derived compounds of therapeutic importance for diseases such as cancer and AIDS.
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The Prebiotic Synthesis of Oligonucleotides
Origins of Life, 1974This paper is primarily a review of recent developments in the abiotic synthesis of nucleotides, short chain oligonucleotides, and their mode of replication in solution. It also presents preliminary results from this laboratory on the prebiotic synthesis of thymidine oligodeoxynucleotides.
J, Oró, E, Stephen-Sherwood
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Diagnosis with oligonucleotides
Clinics in Dermatology, 1991Abstract Protein-based immunohistochemical techniques like immunoperoxidase methods are now routinely used in many diagnostic dermatopathology laboratories. This is possible because of the availability of antibodies that react with specific, diagnostically useful proteins and because there are simple but sensitive detection systems.
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Current Opinion in Biotechnology, 1992
Rapid progress in oligonucleotide therapeutics has continued over the past year as major programs established in the past four years have grown and begun to be productive. Important advances were reported in the medicinal chemistry of oligonucleotides and in understanding their pharmacodynamic properties.
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Rapid progress in oligonucleotide therapeutics has continued over the past year as major programs established in the past four years have grown and begun to be productive. Important advances were reported in the medicinal chemistry of oligonucleotides and in understanding their pharmacodynamic properties.
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Synthesis of Oligonucleotide—Peptide and Oligonucleotide—Protein Conjugates
ChemInform, 2004AbstractFor Abstract see ChemInform Abstract in Full Text.
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2011
A brief historical introduction describes early attempts to silence specific genes using the antisense oligonucleotides that flourished in the 1980s. Early aspirations for therapeutic applications were almost extinguished by the unexpected complexity of oligonucleotide pharmacology.
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A brief historical introduction describes early attempts to silence specific genes using the antisense oligonucleotides that flourished in the 1980s. Early aspirations for therapeutic applications were almost extinguished by the unexpected complexity of oligonucleotide pharmacology.
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Labeling of Oligonucleotides with Fluorescein
Molecular Biotechnology, 1997The labeling of oligonucleotide probes using a fluorescein-labeled nucleotide is described. The reaction is characterized by careful control of the nucleotide and probe molar ratio in order to produce a tail that gives good detection sensitivity without compromising hybridization stringency control of the probe sequence.
P M, Chadwick, I, Durrant
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Circular Oligonucleotides: New Concepts in Oligonucleotide Design
Annual Review of Biophysics and Biomolecular Structure, 1996Recent progress in the synthesis and properties of circular oligonucleotides as ligands for DNA and RNA and as templates for polymerase enzymes is described. Small synthetic circular DNAs, RNAs, and chimeric analogues ranging from 28 to 74 nucleotides in size have been synthesized with the use of a nonenzymatic ligation strategy.
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Chemical Communications, 2020
Oligonucleotides containing dU, which are called booster oligonucleotides, are excised by uracil-DNA glycosylase in the nucleus and efficiently release complementary strands.
Lei Wang +3 more
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Oligonucleotides containing dU, which are called booster oligonucleotides, are excised by uracil-DNA glycosylase in the nucleus and efficiently release complementary strands.
Lei Wang +3 more
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Synthesis of Oligonucleotides and Oligonucleotide Analogues
1989The aim of this review is to outline modern methods for synthesizing natural oligodeoxynucleotides and certain analogues that may be inhibitors of gene expression. As a consequence, several DNA chemical synthesis methodologies such as the phosphate diester and phosphate triester approaches, which are now primarily only of historical interest, will not ...
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