Results 341 to 350 of about 641,320 (378)
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2011
A brief historical introduction describes early attempts to silence specific genes using the antisense oligonucleotides that flourished in the 1980s. Early aspirations for therapeutic applications were almost extinguished by the unexpected complexity of oligonucleotide pharmacology.
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A brief historical introduction describes early attempts to silence specific genes using the antisense oligonucleotides that flourished in the 1980s. Early aspirations for therapeutic applications were almost extinguished by the unexpected complexity of oligonucleotide pharmacology.
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1993
Abstract 10.1 Single-crystal X-ray structure determination of oligonucleotides containing four or more bases Tables 10.1-10.5 list the principal references to structure determinations published between 1979 and mid-1989. There are three main families of double-helical oligonucleotide structures.
Olga Kennard +2 more
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Abstract 10.1 Single-crystal X-ray structure determination of oligonucleotides containing four or more bases Tables 10.1-10.5 list the principal references to structure determinations published between 1979 and mid-1989. There are three main families of double-helical oligonucleotide structures.
Olga Kennard +2 more
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Boron Containing Oligonucleotides
Nucleosides, Nucleotides and Nucleic Acids, 1998Abstract Synthesis, physicochemical and biological properties of novel class of oligonucleotide analogues, bearing boron modifications are described. Dedicated to the memory of Professor Tsuijaki Hata.
R F, Schinazi, Z J, Lesnikowski
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Synthesis of Oligonucleotide—Peptide and Oligonucleotide—Protein Conjugates
ChemInform, 2004AbstractFor Abstract see ChemInform Abstract in Full Text.
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Carbohydrate‐Oligonucleotide Conjugates
Current Protocols in Nucleic Acid Chemistry, 2009AbstractThis unit describes a strategy for attaching two mannose and two galactose residues to an oligonucleotide. This conjugation can be performed at the 5′‐end of the oligonucleotide sequence, using modified phosphoramidites. First, the oligonucleotide scaffold is synthesized on solid support using a DNA synthesizer, with commercially available and ...
Gwladys, Pourceau +3 more
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Trichloroacetaldehyde modified oligonucleotides
Bioorganic & Medicinal Chemistry Letters, 2005Some commercial batches of dichloroacetic acid (DCA) contain traces of chloral (trichloroacetaldehyde). Using such DCA to effect detritylation during solid-phase oligonucleotide synthesis results in the formation of a family of process impurities in which the atoms of chloral (Cl3CCHO) are incorporated between the 5'-oxygen and phosphorus atoms of an ...
Hans, Gaus +7 more
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Antibody–oligonucleotide conjugates enter the clinic
Nature reviews. Drug discovery, 2021Asher Mullard
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Targeting Therapeutic Oligonucleotides
New England Journal of Medicine, 2017Two recent studies test whether oligonucleotide drugs that are tailored to target different cell types — the hepatocyte and the myocyte and cardiomyocyte — actually target those cell types.
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Diagnosis with oligonucleotides
Clinics in Dermatology, 1991Abstract Protein-based immunohistochemical techniques like immunoperoxidase methods are now routinely used in many diagnostic dermatopathology laboratories. This is possible because of the availability of antibodies that react with specific, diagnostically useful proteins and because there are simple but sensitive detection systems.
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Expression monitoring by hybridization to high-density oligonucleotide arrays
Nature Biotechnology, 1996D. Lockhart +10 more
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