Results 111 to 120 of about 130,578 (251)

Approximating Clustering of Fingerprint Vectors with Missing Values

, 2005
The problem of clustering fingerprint vectors is an interesting problem in Computational Biology that has been proposed in (Figureroa et al. 2004). In this paper we show some improvements in closing the gaps between the known lower bounds and upper ...
A. Figueroa, C.H. Papadimitriou, G. Ausiello, Giancarlo Mauri, Gianluca Della Vedova, L. Valinsky, L. Valinsky, M. Chlebík, P. Alimonti, Paola Bonizzoni, R. Drmanac, Riccardo Dondi, S. Drmanac, S. Drmanac   +13 more
core   +1 more source

Technological Innovations and Applications of Spatial Transcriptomics in Livestock and Poultry Research

Animal Research and One Health, EarlyView.
The paper is divided into three main sections: a review of the development of spatial transcriptomics technology, its applications in livestock and poultry research, and its future prospects. This article provides an overview of the current state of spatial transcriptomics in animal research, exploring its integration with multiomics technologies as ...
Mingyu Wang, Ao Guo, Lin Zhang, Shengru Wu, Juan Du, Taiyong Yu   +5 more
wiley   +1 more source

Short communication: Dynamic chemical labelling allows the measurement of the paracetamol toxicity biomarker microRNA‐122 in hospital clinical laboratories

British Journal of Clinical Pharmacology, EarlyView.
MicroRNA‐122 (miR‐122) is a sensitive biomarker for paracetamol‐induced liver injury. This study assessed the diagnostic performance of dynamic chemical labelling (DCL) combined with an immunoassay platform to quantify miR‐122 in human serum, as a proof‐of‐concept for hospital use.
Samar Alzeer, Antonio Marin‐Romero, Bárbara López‐Longarela, Juan J. Guardia‐Monteagudo, F. Javier Lopez‐Delgado, Salvatore Pernagallo, Juan J. Diaz‐Mochon, Mavys Tabraue‐Chavez, Kathleen Scullion, James W. Dear   +9 more
wiley   +1 more source

Stereo‐cell: A planar DNA nanoball‐array route to ultrahigh‐throughput, imaging‐integrated single‐cell profiling

BMEMat, EarlyView.
This perspective positions Stereo‐cell as a scalable, unbiased capture platform that unifies phenotypes, spatial context, transcriptomics, proteomics, and EV detection on‐chip. By integrating imaging and CITE‐style readouts with subcellular spatial transcriptomics, it resolves rare and large cells alike. We highlight applications from PBMC benchmarking
Chao Wang, Miao Huang, Junxia Han, Mingyuan Sun, Haijun Li, Yu Zhang, Hong Liu, Lin Han   +7 more
wiley   +1 more source

NF-{kappa}B-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses [PDF]

, 2006
Activation of mammalian innate and acquired immune responses must be tightly regulated by elaborate mechanisms to control their onset and termination. MicroRNAs have been implicated as negative regulators controlling diverse biological processes at the ...
Baltimore, David, Boldin, Mark P., Chang, Kuang-Jung, Taganov, Konstantin D.   +3 more
core  

Unlocking Biomolecule Modification with Light‐Promoted Photocatalyst‐Free Approaches: Current Tools, Challenges, and Perspectives

ChemistryEurope, EarlyView.
This Perspective focuses on photocatalyst‐free, photoinduced modifications of biomolecules, emphasizing transformations mediated by electron donor–acceptor complexes. Mechanistic aspects, current limitations, and future opportunities are discussed, providing insight into the field of bioconjugation.
Milene Hornink, Maria Eduarda C. Thedy, Eugénie Romero, Gary A. Molander   +3 more
wiley   +1 more source

Nucleic acid - protein fingerprints. Novel protein classification based on nucleic acid - protein recognition [PDF]

, 2012
Protein chemistry uses protein description and classification based on molecular mass and isoelectric point as general features. Enzymes are also compared by enzymatic reaction constants, namely Km and kcat values. Proteins are also studied by binding to
Alexander Krylov, Renad Zhdanov
core   +1 more source

Fluorinated Guanidino‐Polyamine Conjugates With Ribonuclease Activity – Toward a Therapeutic Tool for Multi‐Drug Therapy

Chemistry – A European Journal, EarlyView.
This study presents a first‐in‐class demonstration of polymeric cationic gene delivery vectors that exhibit intrinsic artificial ribonuclease activity. Based on low‐generation PAMAM dendrimers and low molecular weight PEI polymers functionalized with a fluorinated linker containing a guanidino group, our conjugates simultaneously enable gene ...
Carola Romani, Paola Gagni, Riccardo Salvio, Mattia Sponchioni, Alessandro Volonterio   +4 more
wiley   +1 more source

Targeting G‐Rich lncRNA and its Structural Polymorphism with Selective G‐Quadruplex Ligands: An NMR Study

Chemistry – A European Journal, EarlyView.
The REG1CP‐derived RNA oligonucleotide SL15P adopts a parallel G‐quadruplex (rGQ) structure. In this study, we investigate the effect of several well‐characterized ligands, originally developed for DNA GQs, on the RNA counterpart, with the aim of evaluating their binding ability and specific binding modes.
Giuseppe Satta, Jasna Brčić, Janez Plavec   +2 more
wiley   +1 more source

Development of High-Throughput Genomic Resources to Inform White-Tailed Deer Population and Disease Management. [PDF]

Mol Ecol Resour
ABSTRACT White‐tailed deer (Odocoileus virginianus) are the most abundant and widespread cervid in North America. Genetic data are used as a tool to monitor populations and make management decisions for this game species. However, the development and use of genomic tools that can generate a set of markers suitable for longitudinal genomic data ...
Navarro D, Latch EK, Tallon AK, Ott-Conn CN, DeYoung RW, Walsh DP, Euclide PT, R G C, Larson WA, Seetharam AS, Severin AJ, Reecy JM, Hu ZL, Cantrell JR, Carstensen M, Caudell JN, Killmaster CH, Lockwood ML, McKinley WT, Norton AS, Schuler KL, Storm DJ, Sumners JA, Walter WD, Blanchong JA.   +24 more
europepmc   +2 more sources