Results 211 to 220 of about 131,505 (250)

Placental Extracellular Vesicles Exhibit Reduced Neurogenic Potential Linked to Changes in Their miRNA Landscape Upon HCMV Infection

Journal of Extracellular Biology, Volume 5, Issue 1, January 2026.
ABSTRACT Extracellular vesicles (EVs) are key mediators of maternal–foetal communication, regulating placental function and foetal development through the transfer of bioactive molecules. Although placental EVs play a crucial role in placental function during pregnancy, their contribution to foetal development, notably foetal brain, remains poorly ...
Charlène Martin, Hélène Martin, Mathilde Bergamelli, Lhorane Lobjois, Lucie Franco, Emma Bordes, Alexandra Benchoua, Stéphanie Balor, Diala Kantar, Etienne Coyaud, Frédéric Martins, Alexandre Favereaux, Cécile E. Malnou   +12 more
wiley   +1 more source

Improved in vivo gene knockout with high specificity using multiplexed Cas12a sgRNAs. [PDF]

Nat Commun
Port F, Buhmann MA, Zhou J, Stricker M, Vaughan-Brown A, Michalsen AC, Roßmanith E, Pöltl A, Großkurth L, Huber J, Menendez Kury LB, Weberbauer B, Hübl M, Puscher E, Heigwer F, Boutros M.   +15 more
europepmc   +1 more source

Organoids in Cancer Research and Regenerative Medicine: Current Status, Challenges, and Future Prospects

MedComm, Volume 7, Issue 1, January 2026.
The management of cancer and tissue regeneration remains a substantial challenge to global health. Organoids, which are stem cell‐derived three‐dimensional multicellular structures, are revolutionizing biomedical research. Therefore, this review highlights their applications in cancer research and regenerative medicine, while discussing current ...
Ruiyang Li, Yuezhou Wu, Zhu'anzhen Zheng, Fengjin Zhou, Ke Xu, Jiacan Su   +5 more
wiley   +1 more source

IMAGE: INTEGRATE-Mediated <i>Agrobacterium</i> Genome Engineering. [PDF]

Front Microbiol
Aliu E, Chen LC, Lee K, Wang K.
europepmc   +1 more source

A Novel Intronic Variant Causes Aberrant Splicing of PCDH15 in a Family With Usher Syndrome Type 1F

Molecular Genetics &Genomic Medicine, Volume 14, Issue 1, January 2026.
Minigene splicing assays elucidated the pathogenicity of a novel intronic c.3717+5G>A mutation in the PCDH15 gene, which was identified in a family affected by Usher syndrome type 1F. The results demonstrated that the c.3717+5G>A mutation can lead to exon 27 skipping and retention of 51 bp at the 5′ end of intron 27, resulting in truncated or abnormal ...
Qifan Ma, Chenyang Xu, Xueqin Xu, Yanbao Xiang   +3 more
wiley   +1 more source

A Biosensor Platform for Detecting the Dissipation of Transmembrane Gradients in Single Liposomes. [PDF]

Anal Chem
Zhang C, Bowen ME.
europepmc   +1 more source

The Incremental Yield of CMA Over Karyotype in Fetal Growth Restriction—A Systematic Review and Meta‐Analysis

Prenatal Diagnosis, Volume 46, Issue 1, Page 56-74, January 2026.
ABSTRACT The main objective of our study was to conduct a systematic literature review and a meta‐analysis to evaluate the incremental yield of chromosomal microarray analysis compared with karyotyping in cases of fetal growth restriction. Our review was designed according to the PRISMA guidelines.
Ioakeim Sapantzoglou, Evangelia Kontogeorgi, Vasilios Pergialiotis, Konstantinos Tasias, Angeliki Rouvali, Afroditi Pegkou, Marianna Theodora, Georgios Daskalakis, Panagiotis Antsaklis   +8 more
wiley   +1 more source

Regulatory T Cells and Nanomaterials: Dual Perspectives in Therapeutics and Immunomodulation

Small Science, Volume 6, Issue 1, January 2026.
Tregs control immune tolerance but can also enable tumor escape. Nanomaterials can now expand or stabilize Tregs to treat autoimmunity and support transplantation or conversely disrupt tumor Tregs to boost antitumor immunity. We also discuss unintended Treg modulation by nanoparticles, safety and manufacturing challenges, and future translational ...
Yiyin Chen, Haibo Huang, Xiang Wang, Xinghao Yu, Ziyan Huang, Zhou Jin, Chen Chen, Yan Chen, Bruce R. Blazar, Yang Xu, Yunjie Lu   +10 more
wiley   +1 more source

Parallel stopped-flow interrogation of diverse biological systems at the single-molecule scale. [PDF]

Nat Methods
Kiselev R, Brady RA, Modak A, Cruz-Navarrete FA, Alejo JL, Terry DS, Altman RB, Asher WB, Javitch JA, Blanchard SC.   +9 more
europepmc   +1 more source

Emerging Biomedical Engineering Therapies for Infected Diabetic Foot Ulcers: Toward Antibacterial Functionalization and Pathology‐Responsive Regulation

Small Science, Volume 6, Issue 1, January 2026.
Infected diabetic foot ulcer endangers patients with high amputation, disability, mortality risks, and heavy medical burdens. This review analyzes its pathogenic factors, the limitations of current treatments, the breakthroughs of responsive antimicrobial biomaterials, and the challenge of multifunctional biomaterial innovations for further developing ...
Yaqi Yao, Mengyi Huang, Yuetong Li, Yiqi Lin, Junjie Dong, Jianhang Du, Aixia Zhai, Changlong Bi, Luoyuan Li   +8 more
wiley   +1 more source