Results 211 to 220 of about 708,274 (274)

Long Noncoding RNA TRIBAL Links the 8q24.13 Locus to Hepatic Lipid Metabolism and Coronary Artery Disease. [PDF]

Circ Genom Precis Med
Soubeyrand S, Lau P, Nikpay M, Ma L, Bjorkegren JLM, McPherson R.   +5 more
europepmc   +1 more source

In Vitro Structure–Activity Relationship Stability Study of Antisense Oligonucleotide Therapeutics Using Biological Matrices and Nucleases

Pharmacology Research &Perspectives, Volume 13, Issue 3, June 2025.
ABSTRACT The primary degradation pathway for antisense oligonucleotides (ASOs) involves endonuclease and exonuclease‐mediated breakdown. The effect of various chemical modifications on the stability of oligonucleotides has not been systematically investigated.
Jelena Lovrić, Jingjing Yan, XueQing Li, Tony Karlsborn, Mattias Bood, Anders Dahlén, Constanze Hilgendorf, Deepak Kumar Bhatt   +7 more
wiley   +1 more source

Discovery of RNA Biomarkers for Prostate Cancer Using Cross-Platform Transcriptomics. [PDF]

Int J Mol Sci
Visser WCH, de Jong H, Smit FP, Shrivastava J, Poole JC, Leenders WPJ, Melchers WJG, Mulders PFA, Schalken JA.   +8 more
europepmc   +1 more source

SPECIFIC: A systematic framework for engineering cell state‐responsive synthetic promoters reveals key regulators of T cell exhaustion

Quantitative Biology, Volume 13, Issue 2, June 2025.
Abstract Cell state‐specific synthetic promoters are essential tools for studying and manipulating cellular function, yet their design remains challenging, particularly for complex states such as T cell exhaustion. Here we present SPECIFIC (Synthetic Promoter Engineering for Cellular State Identification and Functional Analysis), an integrated ...
Zhaoyu Zhang, Xiaoyu Qiu, Hui Ning, Zihua Huang, Minzhen Tao, Min Liang, Zhen Xie   +6 more
wiley   +1 more source

Novel SMARCA4 Variant in an Infant With Atypical Teratoid Rhabdoid Tumor. [PDF]

J Pediatr Hematol Oncol
Haldipurkar SK, Damodharan SN, Rathbun P, Yap KL, Wadhwani N, Waanders AJ.   +5 more
europepmc   +1 more source

Droplet Microfluidics for Advanced Single‐Cell Analysis

Smart Medicine, Volume 4, Issue 2, June 2025.
This paper reviews the transformative impact of droplet microfluidics on single‐cell research. It highlights current advancements in encapsulation techniques, applications in high‐throughput screening, and the study of intercellular and cell‐microorganism interactions.
Chang Liu, Xiaoyu Xu
wiley   +1 more source

Investigating Single-Molecule Molecular Inversion Probes for Medium-Scale Targeted DNA Methylation Analysis. [PDF]

Epigenomes
Simons RB, Adams HHH, Kayser M, Vidaki A.   +3 more
europepmc   +1 more source

Prenatal Diagnosis of Proteus Syndrome: About a Case

American Journal of Medical Genetics Part A, Volume 197, Issue 5, May 2025.
ABSTRACT Proteus syndrome (PS) is a rare disorder (< 1/1000000), marked by progressive overgrowth commonly impacting the skeleton, skin, adipose tissue, and central nervous system. Clinical criteria were established in 2019. PS arises from a somatic activating variation in the AKT1 gene.
Luana Giovannangeli, Virginie Magry, Florence Jobic, Kahia Messaoudi, Walaa Darwiche, Marianne Perriere, Alexis Billes, Ségolène Delmas Lanta, Alice Masurel, Gilles Morin, Guillaume Jedraszak   +10 more
wiley   +1 more source

Whole genome sequencing for copy number variant detection to improve diagnosis and management of rare diseases. [PDF]

Dev Med Child Neurol
Bowman P, Grimes H, Dallosso AR, Berry I, Mullin S, Rankin J, Low KJ.   +6 more
europepmc   +1 more source