Results 271 to 280 of about 1,424,575 (357)

In situ imaging and microbiome analysis of calculus-like deposits at the root apex: A case report of refractory apical periodontitis. [PDF]

Int Endod J
Mota de Almeida FJ, Rakhimova O, Romani Vestman N, Lee NM, Brundin M.   +4 more
europepmc   +1 more source

Internal Phase Separation in Synthetic DNA Condensates

Advanced Science, EarlyView.
The modular, programmable system of DNA nanostructures developed provides programmatic control over multiphase condensate behavior, enabling mapping onto a predictive Flory‐Huggins model. This combined experimental and theoretical framework will help address open questions in condensate biophysics and facilitate the rational design of functional ...
Diana A. Tanase, Dino Osmanović, Roger Rubio‐Sánchez, Layla Malouf, Elisa Franco, Lorenzo Di Michele   +5 more
wiley   +1 more source

Fluorogenic oligonucleotide cleavage probes with a branched linker improve RNA detection. [PDF]

Nucleic Acids Res
Maru B, Edinboro A, Katolik A, El-Khoury R, Basran K, Wahba AS, Damha MJ, Luedtke NW, McKeague M.   +8 more
europepmc   +1 more source

Lenvatinib Plus Paclitaxel as Second‐Line Therapy for Advanced Gastric Cancer Patients: A Dose Escalation Exploratory Study

Advanced Science, EarlyView.
This study determines the maximum tolerated dose of lenvatinib in combination with paclitaxel as second‐line therapy for advanced gastric cancer patients. A dynamic network biomarker panel associated with patient prognosis and response to treatment is established.
Chenfei Zhou, Jinling Jiang, Liting Guo, Wenqi Xi, Junwei Wu, Qu Cai, Jun Ji, Feng Qi, Jun Zhang   +8 more
wiley   +1 more source

Novabeads: Stimuli-Responsive Signal-Amplifying Hydrogel Microparticles for Enzymeless Fluorescence-Based Detection of microRNA Biomarkers. [PDF]

Small
Lu H, Samman F, Hasan E, Alsulaiman D.
europepmc   +1 more source

Macrophage Zc3h12c Limits Tissue Inflammation and Injury via Alternative Splicing of Pre‐mRNA

Advanced Science, EarlyView.
This work defines the context‐dependent function of Zc3h12c in macrophages using the Tnfrsf11a‐Cre system. It reveals Zc3h12c's dual mechanism—regulating RNA degradation and alternative splicing—with STAT1 as a key target. The findings elucidate a novel post‐transcriptional pathway and identify STAT1 isoforms as potential therapeutic targets for kidney
Chenyu Li, Julian Aurelio Marschner, Yoshihiro Kusunoki, Ningxin Zhang, Xiaoxin Li, Hao Deng, Zhibo Zhao, Kanako Watanabe‐Kusunoki, Zhihui Zhu, Yan Xu, Stefanie Steiger, Maciej Lech, Katalin Susztak, Christian Schulz, Hans‐Joachim Anders   +14 more
wiley   +1 more source

Genetic and Functional Dissection of the NFKB2 Gene: Implications for Milk Fatty Acid Biosynthesis in Dairy Cattle. [PDF]

FASEB J
Shi L, Guo Z, Shen N, Li C, Han B, Sun D.   +5 more
europepmc   +1 more source

One‐Pot Isothermal Nucleic Acid Amplification Assisted CRISPR/Cas Detection Technology: Challenges, Strategies, and Perspectives

Advanced Science, EarlyView.
This review combines the current status of CRISPR (Clustered Regularly Interspaced Short Palindromic Repeat)‐based molecular diagnostic technology to expound the necessity and challenges faced in promoting the development of one‐pot detection. Besides, the focus is on a comprehensive summary and incisive analysis of emerging strategies for one‐pot ...
Hongyan Liu, Hui Yin, Leshan Xiu, Wenyu Wu, Qinqin Hu, Yingchen Xia, Brianna Garcia, Shamsuttiyeba Shifa, Hui Chen, Min Li, Kun Yin   +10 more
wiley   +1 more source

Establishment of a genome map-based karyotype of <i>Artemisia argyi</i> and identification of a new octoploid. [PDF]

Front Plant Sci
Li L, Du P, Liu D, Li X, La G, Shi G, Dai D, Yang T.   +7 more
europepmc   +1 more source

Constitutive Androstane Receptor in Macrophages Regulates Toll‐Like Receptor 4‐Mediated Innate Immune Responses Against Endotoxemic Liver Injury

Advanced Science, EarlyView.
The present study uncovers a novel role of constitutive androstane receptor (CAR) in inflammation‐mediated damage. CAR activation in macrophages inhibits proinflammatory macrophages by interacting with Tlr4, which protects against endotoxemic liver injury.
Renjie Cao, Tingting Zhao, Ying Wang, Shaofei Song, Yuan Li, Mengling Hou, Yanxin Zhang, Sengpeng Wong, Siqi Wang, Yuran Wang, Hong Peng, Min Huang, Yiming Jiang   +12 more
wiley   +1 more source