Results 171 to 180 of about 143,834 (286)

Pharmacokinetic/Pharmacodynamic Translation and Model-Informed Drug Development for Oligonucleotide Therapeutics. [PDF]

J Clin Pharmacol
Gupta P, Magee M, Ayyar VS.
europepmc   +1 more source

Epigenetic Regulation of Liver Fibrosis: Mechanisms and Therapeutic Implications

Portal Hypertension &Cirrhosis, EarlyView.
This review synthesizes the epigenetic mechanisms—DNA methylation, histone modifications, and non‐coding RNAs—that drive hepatic stellate cell activation and the progression of liver fibrosis. It further evaluates emerging therapeutic strategies targeting these epigenetic regulators, including DNA methyltransferase and histone deacetylase inhibitors ...
Maryam Jadid Tavaf, Mahboobeh Ebrahimi Varkiani, Saeid Abroun, Pedram Asadi‐Sarabi, Shukoofeh Torabi, Elham Rismani, Mohammad Majd Hammour, Andreas K. Nüssler, Massoud Vosough   +8 more
wiley   +1 more source

Genomics and epigenomics of tissue repair: Implications for personalized medicine

Precision Medical Sciences, EarlyView.
Genomic and epigenomic mechanisms govern tissue repair and regeneration through dynamic regulation of inflammation, cell fate, and extracellular matrix remodeling. The integration of multi‐omics, artificial intelligence, and precision regenerative therapies enables biomarker‐driven, personalized approaches to enhance healing and minimize fibrosis ...
Jharna Medhi, Chandrashekar Thalluri, Sarad Pawar Naik Bukke, Piyali Dey, Mallikarjun Vasam, Ananda Kumar Chettupalli, Swetha Kumari Koduru, Gali Avinash Kumar   +7 more
wiley   +1 more source

Antisense Oligonucleotide-Mediated <i>XIST</i> Knockdown Modulates Endogenous Pluripotency-Associated Transcription Factor Expression in Porcine Female Somatic Cells. [PDF]

Animals (Basel)
Chen X, Chu X, Huang J, Zhang L, Lu F, Yang N, Dai L, Xu R.   +7 more
europepmc   +1 more source

Chemical and Biological Determinants of PEG‐Lipid Shedding From Therapeutic Nanoparticles

Small, EarlyView.
PEG‐lipids play a central role in governing lipid nanoparticle stability, targeting, and function. However, PEG‐lipids can “shed” from the nanoparticle surface in biological environments, with the extent and kinetics of shedding influenced by chemical and biological factors.
Ethan P. Cisneros, Aadya S. Wijesekera, Lisa R. Volpatti   +2 more
wiley   +1 more source

High-fidelity genotyping and therapeutic oligonucleotides analysis by liquid-phase ion trap coupled with mass spectrometry. [PDF]

Sci Adv
Fu X, Hong J, Lu S, Xu W.
europepmc   +1 more source

A Luminescent PEI/Cy5‐Citrate‐Functionalized Carbonated Apatite Nanoplatform for In Vitro Gene Delivery and In Vivo Traceability

Small, EarlyView.
A luminescent PEI/Cy5‐citrate‐functionalized carbonated apatite nanoplatform combines biocompatibility, plasmid delivery, and Cy5‐based traceability. The system enables effective in vitro gene delivery while preserving cell viability and allows real‐time in vivo fluorescence tracking of the nanocarrier.
Laura Garrido Martín, Marta García Gallego, Raquel Fernández Penas, José Manuel Peula García, Jaime Gómez Morales, Houria Boulaiz   +5 more
wiley   +1 more source

An Enzymatic Platform for Late-Stage (Radio)isotope Labelling of Oligonucleotides With Methyltransferases. [PDF]

Angew Chem Int Ed Engl
Swanson CRB, Kauhl U, Edelmann MR, Seebeck FP.   +3 more
europepmc   +1 more source

Antisense Oligonucleotides [PDF]

, 2020
openaire   +1 more source

Programmable Assembly of Higher‐Order DNA Nanostructures from Microbial ssDNA Staple Libraries

Small, EarlyView.
A phage‐free, microbial platform produces programmable circular ssDNA libraries that are enzymatically converted into DNA origami staple pools. Rolling‐circle replication generates sequence‐complex ssDNA with >99% fidelity, enabling assembly of DNA tiles and tubules and supporting nanostructure formation even in crude cellular lysates.
Ming Hung Yen, Mallikarjuna Reddy Kesama, Yancheng Du, Jong Hyun Choi, Kevin V. Solomon   +4 more
wiley   +1 more source