Results 151 to 160 of about 414,656 (346)
Pharmacokinetics, biodistribution and cell uptake of antisense oligonucleotides.
Advanced Drug Delivery Reviews, 2015 R. Geary, D. Norris, R. Yu, C. Bennett
semanticscholar +1 more source
Okanin Suppresses the Growth of Colorectal Cancer Cells by Targeting at Peroxiredoxin 5
Advanced Science, EarlyView.Okanin suppresses colorectal cancer growth by directly targeting PRDX5. This natural compound selectively binds peroxiredoxin 5 (PRDX5), inhibiting its activity and inducing WSB1‐mediated degradation. PRDX5 loss elevates ROS, suppresses GPX4 via SIAH2, and further triggers cell death (apoptosis and ferroptosis).
Ji Zhong Zhao +9 more
wiley +1 more source
On the Phe-tRNA induced binding of fluorescent oligonucleotides to the ribosomal decoding site [PDF]
, 1977 Heinrich M. Menzel
openalex +1 more source
Advanced Science, EarlyView.Skullcapflavone II (SkII) significantly alters serine metabolism in gastric cancer cells by directly targeting the L‐serine transporter SLC1A4, thereby inhibiting L‐serine uptake rather than de novo synthesis. This disruption of serine metabolism by SkII leads to increased oxidative stress and consequent mitochondrial damage.
Jing Zhao +10 more
wiley +1 more source
Oligonucleotide mapping of non-radioactive virus and messenger RNAs [PDF]
, 1977 David Frisby
openalex +1 more source
PRDM16 Reduces Cellular Senescence by Upregulating GSTM1
Advanced Science, EarlyView.Cellular senescence drives aging and aging‐related organ disorders, yet PRDM16's role remains unexplored. This work uncovers that PRDM16 decreases significantly in aged organs, while its loss accelerates cellular senescence and aging‐related organ injury.
Qian Yuan +7 more
wiley +1 more source
Studies on transfer ribonucleic acids and related compounds. IX(1)Ribo-oligonucleotide synthesis using a photosensitive o-nitrobenzyl protection at the 2′-hydroxyl group [PDF]
, 1974 Eiko Ohtsuka +2 more
openalex +1 more source
Advanced Science, EarlyView.A rapid, portable lateral flow strip assay for on‐site mRNA quality control is developed, enabling sequence‐independent analysis of 5' capping, integrity, and LNPs encapsulation efficiency. This cost‐effective method offers real‐time stability monitoring, reduced sample requirements, and comparable accuracy to standard techniques, enhancing ...
Dengwang Luo +9 more
wiley +1 more source