Results 231 to 240 of about 584,539 (379)

5′tRF‐GlyGCC Promotes Breast Cancer Progression via LDHA‐Mediated Glycolysis and Macrophage Polarization

Advanced Science, EarlyView.
5’tRF‐GlyGCC promotes breast cancer malignancy by binding to LDHA. This interaction, facilitated by FGFR1 and LDHA phosphorylation, enhances glycolysis. Additionally, 5’tRF‐GlyGCC/LDHA signaling recruits and polarizes macrophages into a pro‐tumor M2 state via CCL7, thus remodeling the tumor microenvironment.
Cheng Yi, Yunqing Lu, Xing Chang, Ying Wang, Jiawang Zhou, Guoyou Xie, Lijun Tao, Zhaotong Wang, Yifan Tian, Lihong Wang, Feng Tang, Yijing Zheng, Xinchen Yue, Jinping Lei, Xiansong Wang, Lichen Ge, Zhuojia Chen, Hongsheng Wang   +17 more
wiley   +1 more source

Nucleic acid base pair open states by hydrogen exchange. [PDF]

Proc Natl Acad Sci U S A
Englander SW.
europepmc   +1 more source

Preservation of Complex Multiphase Architectures in Polymer‐Based Artificial Cells by Photo‐Crosslinking

Advanced Science, EarlyView.
Phase separation organizes cellular components, yet stabilizing such dynamic structures in artificial cells remains challenging. A photo‐crosslinking approach is presented that prolongs the lifetime of different structures in coacervate‐based artificial cells while maintaining dynamic formation.
Madelief A. M. Verwiel, Alexander B. Cook, Yiǧitcan Sümbelli, Nadia A. Erkamp, Jan C. M. van Hest   +4 more
wiley   +1 more source

Mechanistic Insights Into the Retention and Separation Mechanism of Poly(Ethylene Glycol)-Modified Short Oligonucleotides in Anion-Exchange Chromatography. [PDF]

Biotechnol J
Yoshimoto N, Matsumoto T, Ono Y, Kumagai Y.   +3 more
europepmc   +1 more source

Synthesis of an oligonucleotide-derivatized amphipol and its use to trap and immobilize membrane proteins [PDF]

, 2014
Christel Le Bon, Eduardo Antonio Della Pia, Fabrice Giusti, Noémie Lloret, Manuela Zoonens, Karen L. Martinez, Jean‐Luc Popot   +6 more
openalex   +1 more source

A20 Facilitates Oxaliplatin Sensitivity in Colorectal Cancer Through Monoubiquitylation of IKK‐β

Advanced Science, EarlyView.
This study demonstrates that the expression of A20, a ubiquitin‐editing enzyme, is positively correlated with oxaliplatin sensitivity in colorectal cancer (CRC). Mechanistically, A20 enhances oxaliplatin sensitivity by inhibiting NF‐κB nuclear translocation through monoubiquitination of IKK‐β.
Fan Luo, Ting Yang, Jiaxin Cao, Qun Chen, Zhenhai Lu, Feiteng Lu, Chaozhuo Lin, Zengfei Xia, Yuanzhong Yang, Peng Li, Wenjuan Ma, Min Luo, Rongxin Zhang   +12 more
wiley   +1 more source

Thermodynamic Profiling Reveals DNA Polymerase Template Binding, Substrate Incorporation, and Exonuclease Function. [PDF]

Int J Mol Sci
Sun Y, Lin W, Fu K, Gao J, Zhao X, He Y, Tian H.   +6 more
europepmc   +1 more source

Designing Oligonucleotide-Based FISH Probe Sets with PaintSHOP [PDF]

Monika W. Perez, Conor K. Camplisson, Brian J. Beliveau   +2 more
openalex   +1 more source

Sensitivity of splice sites to antisense oligonucleotides in vivo [PDF]

, 1999
Halina Sierakowska, Maria J. Sambade, Daniel Schümperli, Ryszard Kole   +3 more
openalex   +1 more source

RNA therapeutics: beyond RNA interference and antisense oligonucleotides

Nature reviews. Drug discovery, 2012
R. Kole, A. Krainer, S. Altman
semanticscholar   +1 more source