Results 211 to 220 of about 282,363 (268)
Some of the next articles are maybe not open access.
Nephron Experimental Nephrology, 1998
Antisense technology was developed to inhibit gene expression by utilizing an oligonucleotide complementary to the mRNA which encodes the target gene. There are a few possible mechanisms for the inhibitory effects of antisense oligonucleotides. Among them, degradation of mRNA by RNase H is considered to be the major mechanism of action for antisense ...
N, Kashihara, Y, Maeshima, H, Makino
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Antisense technology was developed to inhibit gene expression by utilizing an oligonucleotide complementary to the mRNA which encodes the target gene. There are a few possible mechanisms for the inhibitory effects of antisense oligonucleotides. Among them, degradation of mRNA by RNase H is considered to be the major mechanism of action for antisense ...
N, Kashihara, Y, Maeshima, H, Makino
openaire +2 more sources
2011
A brief historical introduction describes early attempts to silence specific genes using the antisense oligonucleotides that flourished in the 1980s. Early aspirations for therapeutic applications were almost extinguished by the unexpected complexity of oligonucleotide pharmacology.
openaire +2 more sources
A brief historical introduction describes early attempts to silence specific genes using the antisense oligonucleotides that flourished in the 1980s. Early aspirations for therapeutic applications were almost extinguished by the unexpected complexity of oligonucleotide pharmacology.
openaire +2 more sources
RNA therapeutics: beyond RNA interference and antisense oligonucleotides
Nature Reviews Drug Discovery, 2012Sidney Altman +2 more
exaly
Photoinduced Transcription by Using Temporarily Mismatched Caged Oligonucleotides
Angewandte Chemie - International Edition, 2005Alexander Heckel
exaly
Chromatography of oligonucleotides
Archives of Biochemistry and Biophysics, 1959M, STAEHELIN, E A, PETERSON, H A, SOBER
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Antisense Oligonucleotides: Translation from Mouse Models to Human Neurodegenerative Diseases
Neuron, 2017Timothy Miller
exaly