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Oligonucleotide lipoplexes: the influence of oligonucleotide composition on complexation
Biochimica et Biophysica Acta (BBA) - General Subjects, 2001Despite extensive investigations into oligonucleotide lipoplexes, virtually no work has addressed whether the physicochemical properties of these assemblies vary as a function of the constituent oligonucleotide (ODN) sequence and/or composition. The present study was aimed at answering this question.
Meidan, V.M. +4 more
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Synthesis of Oligonucleotide—Peptide and Oligonucleotide—Protein Conjugates
ChemInform, 2004AbstractFor Abstract see ChemInform Abstract in Full Text.
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Immunostimulatory Oligonucleotides
Recent Patents on Inflammation & Allergy Drug Discovery, 2011RNA-protein interactions have been characterized often. Above all, the proteins which are associated with the studied RNA should be precisely identified. The pharmaceutical compositions containing nucleic acids and/or other compounds can be administered by any suitable route for administering medications. The immunostimulatory oligonucleotides play the
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2017
Oligonucleotides (ONs), the focus of the chapter herein, are mostly known for their utility to selectively manipulate RNA processing by increasing or decreasing target gene levels, in particular by inducing enzymatic RNA degradation, blocking or mimicking miRNAs, inhibiting mRNA translation or modulating pre-mRNA splicing.
Covello, Giuseppina +1 more
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Oligonucleotides (ONs), the focus of the chapter herein, are mostly known for their utility to selectively manipulate RNA processing by increasing or decreasing target gene levels, in particular by inducing enzymatic RNA degradation, blocking or mimicking miRNAs, inhibiting mRNA translation or modulating pre-mRNA splicing.
Covello, Giuseppina +1 more
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Synthesis of Oligonucleotides and Oligonucleotide Analogues
1989The aim of this review is to outline modern methods for synthesizing natural oligodeoxynucleotides and certain analogues that may be inhibitors of gene expression. As a consequence, several DNA chemical synthesis methodologies such as the phosphate diester and phosphate triester approaches, which are now primarily only of historical interest, will not ...
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Expert Opinion on Drug Discovery, 2008
Numerous oligonucleotide-based biopharmaceuticals have been tested to suppress disease progression. These potent therapeutics include plasmids containing transgenes, antisense oligonucleotides, ribozymes, DNAzymes, decoys, aptamers and small interfering RNAs.
Yoshitaka, Isaka +3 more
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Numerous oligonucleotide-based biopharmaceuticals have been tested to suppress disease progression. These potent therapeutics include plasmids containing transgenes, antisense oligonucleotides, ribozymes, DNAzymes, decoys, aptamers and small interfering RNAs.
Yoshitaka, Isaka +3 more
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Trends in Biotechnology, 1992
Recent studies have focused on the ability of oligonucleotides to affect the genetic processes of many organisms, including viruses. Hence, oligonucleotides may represent a future source of biotechnologically derived compounds of therapeutic importance for diseases such as cancer and AIDS.
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Recent studies have focused on the ability of oligonucleotides to affect the genetic processes of many organisms, including viruses. Hence, oligonucleotides may represent a future source of biotechnologically derived compounds of therapeutic importance for diseases such as cancer and AIDS.
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Diagnosis with oligonucleotides
Clinics in Dermatology, 1991Abstract Protein-based immunohistochemical techniques like immunoperoxidase methods are now routinely used in many diagnostic dermatopathology laboratories. This is possible because of the availability of antibodies that react with specific, diagnostically useful proteins and because there are simple but sensitive detection systems.
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