Results 191 to 200 of about 282,363 (268)

Bioconjugates for improved delivery of oligonucleotide therapeutics to the central nervous system. [PDF]

Adv Drug Deliv Rev
Lee HJ, Xie Y, Greineder CF, Tessier PM.
europepmc   +1 more source

Distinct Neuropsychiatric Profiles Associated With 17p11.2 Deletions and RAI1 Variants in Smith–Magenis Syndrome

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Smith–Magenis syndrome (SMS) results from either a recurrent 17p11.2 deletion or pathogenic variants in the retinoic acid induced 1 gene (RAI1). While neurodevelopmental impairment and behavioral dysregulation are well recognized, systematic genotype‐stratified analyses across psychiatric domains remain limited.
Albin Blanc, Christophe Nemos, Céline Bonnet, Mathilde Renaud, Sandra Chapuis, Pauline Boiroux, Marie‐Noëlle Babinet, Caroline Demily   +7 more
wiley   +1 more source

Antisense RNA controls the degradation of phycobilisomes in heterocyst-forming cyanobacteria by a transcriptional interference mechanism. [PDF]

Nucleic Acids Res
Álvarez-Escribano I, Brenes-Álvarez M, Georg J, Vioque A, Muro-Pastor AM.   +4 more
europepmc   +1 more source

UBE3A Dosage Imbalance as a Molecular Framework Linking Angelman Syndrome and Dup15q‐Associated Autism Phenotypes

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT UBE3A is a dosage‐sensitive HECT E3 ubiquitin ligase whose neuronal expression is shaped by genomic imprinting at the 15q11.2‐q13 locus. Opposite directions of UBE3A dosage imbalance contribute to distinct neurodevelopmental phenotypes: loss of maternal UBE3A underlies Angelman syndrome, whereas maternally derived 15q11.2‐q13 copy‐number gains,
Ruslan Kurmashev
wiley   +1 more source

MicroRNAs in cancer: biogenesis, biomarkers and therapeutic strategies. [PDF]

Front Med (Lausanne)
Rawat N, Babu N, Hussain A, Panwar AS.
europepmc   +1 more source

A turn-on fluorescent nucleoside enabling sequence-insensitive DNA labeling. [PDF]

Nucleic Acids Res
Li J, Dai Z, He L, Xu J, Xiong C, Wen J, Zhou J, Feng X, Chen X, Li X, Zhou L, Lou C, Huang X, Ming X, Mei H.   +14 more
europepmc   +1 more source

Total Breakthrough Strategy in Hydrophilic Interaction Chromatography for IP-RPLC × HILIC Separation of Oligonucleotides. [PDF]

J Sep Sci
Aebischer MK, Abdurahman Y, Guillarme D.
europepmc   +1 more source

Bottlebrush polymer conjugates for enhanced antisense oligonucleotide therapy in myotonic dystrophy type 1. [PDF]

Nucleic Acids Res
Li Y, Oetheimer C, Wang Y, Heo GS, Wu J, Chang R, Zhang W, Schneider E, Chen J, Fang Y, Wei Y, Nian K, Zhang H, Sherman L, Liu Y, Zhang K.   +15 more
europepmc   +1 more source

Position-Dependent Stabilization of DNA/RNA Duplexes by Site-Specific Incorporation of LNA Nucleosides. [PDF]

J Nucleic Acids
Tomita-Sudo E, Akita T, Sakimoto N, Tahara-Takamine S, Sano R, Iwai S, Kawakami J.   +6 more
europepmc   +1 more source

Combinatorial and rational synthesis of complex, base-modified aptamer libraries on microarrays. [PDF]

RSC Adv
Schaudy E, Lietard J.
europepmc   +1 more source