Results 271 to 280 of about 449,240 (358)

The chemistry of oligonucleotide phosphotriesters and phosphoramidates

, 1978
Robert L. Letsinger
openalex   +2 more sources

EFTUD2 Regulates Cortical Morphogenesis via Modulation of Caspase‐3 and Aifm1 Splicing Pathways

Advanced Science, EarlyView.
EFTUD2, a spliceosomal GTPase linked to MFDM, regulates cortical development through apoptotic control. Conditional Eftud2 knockout in murine neural stem cells induces microcephaly and cortical disorganization, while pathogenic variants drive neuronal loss.
Liping Chen, Ying Li, Yan Yu, Mingze Cai, Hao Li, Minghe Huang, Guochao Yang, Jiageng Guo, Huailin Wang, Zhihong Song, Wei Shen, Huihui Jiang, Haitao Wu   +12 more
wiley   +1 more source

Click Conjugates of Artificial Ribonucleases: Sequence Specific Cleavage with Multiple Turnover. [PDF]

Chemistry
Weber S, Weinrich T, Scheffer U, Kalden E, Göbel MW.   +4 more
europepmc   +1 more source

MdDSK2a‐Like‐MdMTA Module Functions in Apple Cold Response via Regulating ROS Detoxification and Cell Wall Deposition

Advanced Science, EarlyView.
Under cold stress, MdDSK2a‐like is degraded via the 26S proteasome pathway, thereby alleviating the degradation of MdMTA induced by the 26S proteasome and autophagy pathways mediated by MdDSK2a‐like. The accumulated MdMTA increases the m6A levels of cold‐responsive genes, thereby contributing to increased ROS detoxification, deposition of cell wall, as
Nan Hou, Jieqiang He, Chana Bao, Fang Zhi, Xiaoxia Shen, Yu Liu, Chaoshuo Li, Tianle Fan, Xinyue Yang, Baohua Chu, Gege Qin, Zeyuan Liu, Chuang Mei, Bin Tan, Jiancan Feng, Fengwang Ma, Mickael Malnoy, Xuewei Li, Qingmei Guan   +18 more
wiley   +1 more source

Accelerating Biologics PBPK Modelling with Automated Model Building: A Tutorial. [PDF]

Pharmaceutics
Derbalah A, Abdulla T, De Sousa Mendes M, Wu Q, Stader F, Jamei M, Gardner I, Sepp A.   +7 more
europepmc   +1 more source

Primary structure of the archaebacterial Methanococcus vannielii ribosomal protein L12. Amino acid sequence determination, oligonucleotide hybridization, and sequencing of the gene.

, 1988
Olaf Strobel, Andreas K.E. Köpke, Roza Maria Kamp, August Böck, B. Wittmann-Liebold   +4 more
openalex   +1 more source

The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis

Advanced Science, EarlyView.
This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen, Chuan Wu, Fei Tang, Jingyue Zhou, Li Mo, Yanping Li, Jinhan He   +6 more
wiley   +1 more source

DragonRNA: Generality of DNA-primed RNA-extension activities by DNA-directed RNA polymerases. [PDF]

Nucleic Acids Res
Greenwald E, Galls D, Park J, Jain N, Montgomery SB, Roy B, Yin YW, Fire AZ.   +7 more
europepmc   +1 more source

UTX Responds to Nanotopography to Suppress Macrophage Inflammatory Response by Remodeling H3K27me3 Modification

Advanced Science, EarlyView.
Compared with those on the pTi surface, macrophages on the TNTs surface present reduced myosin II contractility, which facilitates the nuclear translocation of the UTX. This reduction decreases the enrichment of the repressive H3K27me3 histone modification at the Abca1 gene locus, which promotes the transcription and protein expression of ABCA1 ...
Hengji Jia, He Zhang, Dingqiang Mo, Bo Xie, Hongdou Qiao, Tao Chen, Haoyue Song, Xinxin Xu, Sheng Yang   +8 more
wiley   +1 more source

A general method for detection and characterization of an mRNA using an oligonucleotide probe.

, 1981
K Agarwal, Janne Brunstedt, B E Noyes
openalex   +1 more source