Results 71 to 80 of about 414,656 (346)
Pd0-Catalyzed Methyl Transfer on Nucleosides and Oligonucleotides, Envisaged as a PET Tracer
Molecules, 2013 The methyl transfer reaction from activated monomethyltin, via a modified Stille coupling reaction, was studied under “ligandless” conditions on fully deprotected 5'-modified nucleosides and one dinucleotide. The reaction was optimized to proceed in
Eric Fouquet +3 more
doaj +1 more source
Intracellular Trafficking and Endosomal Release of Oligonucleotides: What We Know and What We Don't.
Nucleic Acid Therapeutics, 2018 Understanding the cellular uptake and intracellular trafficking of oligonucleotides provides an important basic underpinning for the developing field of oligonucleotide-based therapeutics.
Rudy L. Juliano
semanticscholar +1 more source
Mass Spectrometry of Oligonucleotides
CHIMIA, 2005 Within the past decade mass spectrometry has undoubtedly consolidated its role as a major player in modern bioanalysis. Mass spectrometry of oligonucleotides is an evolving field that has not reached its culmination point yet, as many aspects of oligonucleotide dissociation in gas phase still need to be clarified.
Jan M. Tromp +2 more
openaire +6 more sources
Exosome Proteomics of SOD1D90A Mutation Suggest Early Disease Mechanisms, and FN1 as a Biomarker
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Amyotrophic lateral sclerosis (ALS) is a neuromuscular disease. Super oxide dismutase 1 (SOD1) gene mutations cause ALS, and the D90A mutation is associated with primarily upper motor neuron (UMN) loss. Objective Our goal is to reveal the early cellular events in ALS pathology and identify potential pharmacokinetic biomarkers, using well ...
Mukesh Gautam +6 more
wiley +1 more source
Oligonucleotide analogues with cationic backbone linkages
Beilstein Journal of Organic Chemistry, 2018 Their unique ability to selectively bind specific nucleic acid sequences makes oligonucleotides promising bioactive agents. However, modifications of the nucleic acid structure are an essential prerequisite for their application in vivo or even in ...
Melissa Meng, Christian Ducho
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Alexander disease (AxD) is a severe neurodegenerative disorder caused by gain‐of‐function mutations in the gene for GFAP, which lead to protein aggregation and a primary astrocytopathy. Symptoms vary, but failure to thrive (FTT) and frequent emesis are common and cause significant morbidity. Here we investigate GDF15, a member of the
Tracy L. Hagemann +6 more
wiley +1 more source
Beilstein Journal of Organic Chemistry, 2015 Modifications of the nucleic acid backbone are essential for the development of oligonucleotide-derived bioactive agents. The NAA-modification represents a novel artificial internucleotide linkage which enables the site-specific introduction of positive ...
Boris Schmidtgall +2 more
doaj +1 more source
Biological Procedures Online, 1998 The chemical modification of synthetic oligonucleotides has recently been investigated to improve their pharmacological utilization. In addition to chemical alterations of the backbone and of the heterocyclic bases, their conjugation with amphiphylic ...
Bonora GM, Zaramella S, Veronese FM
doaj +1 more source
Managing the sequence-specificity of antisense oligonucleotides in drug discovery
Nucleic Acids Research, 2017 All drugs perturb the expression of many genes in the cells that are exposed to them. These gene expression changes can be divided into effects resulting from engaging the intended target and effects resulting from engaging unintended targets.
P. Hagedorn +3 more
semanticscholar +1 more source
SNUPN‐Related Muscular Dystrophy: Novel Phenotypic, Pathological and Functional Protein Insights
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective SNUPN‐related muscular dystrophy or LGMDR29 is a new entity that covers from a congenital or childhood onset pure muscular dystrophy to more complex phenotypes combining neurodevelopmental features, cataracts, or spinocerebellar ataxia. So far, 12 different variants have been described.
Nuria Muelas +18 more
wiley +1 more source