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Association between methylenetetrahydrofolate reductase C677T polymorphisms and male oligozoospermia, asthenozoospermia or oligoasthenozoospermia: a case–control study [PDF]

open access: yesScientific Reports
Mutation of methylenetetrahydrofolate reductase (MTHFR) C677T leads to the decrease of folate utilization and the impairment of spermatogenesis. This study attempts to investigate the association between MTHFR C677T polymorphisms and nonobstructive ...
Fu-jia Ren   +2 more
doaj   +2 more sources

Genetic Insights into Azoospermia and Severe Oligozoospermia: Discovering Seven SNPs through GWAS and In Silico Analysis [PDF]

open access: yesCurrent Issues in Molecular Biology
Azoospermia and severe oligozoospermia represent the most extreme forms of male infertility. Despite their prevalence, the genetic foundations of these conditions are not well understood, with only a limited number of genetic factors identified so far ...
Alexia Chatziparasidou   +4 more
doaj   +2 more sources

Preimplantation Testing of Human Blastomeres for Aneuploidy Increases IVF Success in Couples Where Male Partners Had Abnormal Semen Parameters [PDF]

open access: yesBiomedicines
Background/Objectives: Male infertility is becoming a serious problem affecting about 7% of all men worldwide and is a major or contributory factor in 50% of infertile couples overall.
Mahira Ismayilova   +2 more
doaj   +2 more sources

Methylation Status Of MTHFR Promoter And Oligozoospermia Risk: An Epigenetic Study And In Silico Analysis [PDF]

open access: yesCell Journal, 2021
Objective: In this study, we evaluated the effects of promoter methylation of MTHFR on oligozoospermia risk, followed by an in silico analysis. Materials and Methods: In a case-control study, semen samples were collected from infertile and healthy ...
Atefeh Rezaeian   +2 more
doaj   +1 more source

Azoospermia/Oligozoospermia and Prostate Cancer Are Increased in Families of Women With Primary Ovarian Insufficiency. [PDF]

open access: goldJ Endocr Soc
Allen-Brady K   +10 more
europepmc   +2 more sources

From azoospermia to macrozoospermia, a phenotypic continuum due to mutations in the ZMYND15 gene

open access: yesAsian Journal of Andrology, 2022
Thanks to tremendous advances in sequencing technologies and in particular to whole exome sequencing (WES), many genes have now been linked to severe sperm defects.
Zine-Eddine Kherraf   +7 more
doaj   +1 more source

Evaluation of five candidate genes from GWAS for association with oligozoospermia in a Han Chinese population. [PDF]

open access: yesPLoS ONE, 2013
BACKGROUND: Oligozoospermia is one of the severe forms of idiopathic male infertility. However, its pathology is largely unknown, and few genetic factors have been defined.
Miaofei Xu   +13 more
doaj   +1 more source

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