Association between methylenetetrahydrofolate reductase C677T polymorphisms and male oligozoospermia, asthenozoospermia or oligoasthenozoospermia: a case–control study [PDF]
Scientific ReportsMutation of methylenetetrahydrofolate reductase (MTHFR) C677T leads to the decrease of folate utilization and the impairment of spermatogenesis. This study attempts to investigate the association between MTHFR C677T polymorphisms and nonobstructive ...
Fu-jia Ren +2 more
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Genetic Insights into Azoospermia and Severe Oligozoospermia: Discovering Seven SNPs through GWAS and In Silico Analysis [PDF]
Current Issues in Molecular BiologyAzoospermia and severe oligozoospermia represent the most extreme forms of male infertility. Despite their prevalence, the genetic foundations of these conditions are not well understood, with only a limited number of genetic factors identified so far ...
Alexia Chatziparasidou +4 more
doaj +2 more sources
In vitro reconstitution of SPO11‐mediated DNA cleavage reveals mechanistic and clinical insights into meiotic DNA double‐strand break formation [PDF]
Clin Transl MedClinical and Translational Medicine, Volume 15, Issue 6, June 2025.
Hu Z, Tang X, Tong M, Huang Y.
europepmc +2 more sources
Preimplantation Testing of Human Blastomeres for Aneuploidy Increases IVF Success in Couples Where Male Partners Had Abnormal Semen Parameters [PDF]
BiomedicinesBackground/Objectives: Male infertility is becoming a serious problem affecting about 7% of all men worldwide and is a major or contributory factor in 50% of infertile couples overall.
Mahira Ismayilova +2 more
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Methylation Status Of MTHFR Promoter And Oligozoospermia Risk: An Epigenetic Study And In Silico Analysis [PDF]
Cell Journal, 2021 Objective: In this study, we evaluated the effects of promoter methylation of MTHFR on oligozoospermia risk, followed by an in silico analysis. Materials and Methods: In a case-control study, semen samples were collected from infertile and healthy ...
Atefeh Rezaeian +2 more
doaj +1 more source
Azoospermia/Oligozoospermia and Prostate Cancer Are Increased in Families of Women With Primary Ovarian Insufficiency. [PDF]
J Endocr SocAllen-Brady K +10 more
europepmc +2 more sources
Impact of autologous platelet-rich plasma used for treatment of oligozoospermia in dogs on the quality of semen and testicular blood flow. [PDF]
Vet Res CommunMohamed A +3 more
europepmc +2 more sources
From azoospermia to macrozoospermia, a phenotypic continuum due to mutations in the ZMYND15 gene
Asian Journal of Andrology, 2022 Thanks to tremendous advances in sequencing technologies and in particular to whole exome sequencing (WES), many genes have now been linked to severe sperm defects.
Zine-Eddine Kherraf +7 more
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Evaluation of five candidate genes from GWAS for association with oligozoospermia in a Han Chinese population. [PDF]
PLoS ONE, 2013 BACKGROUND: Oligozoospermia is one of the severe forms of idiopathic male infertility. However, its pathology is largely unknown, and few genetic factors have been defined.
Miaofei Xu +13 more
doaj +1 more source