Results 51 to 60 of about 2,887 (179)

Synthesis and Physicochemical Characterization of the Process-Related Impurities of Olmesartan Medoxomil. Do 5-(Biphenyl-2-yl)-1-triphenylmethyltetrazole Intermediates in Sartan Syntheses Exist?

Molecules, 2015
During the process development for multigram-scale synthesis of olmesartan medoxomil (OM), two principal regioisomeric process-related impurities were observed along with the final active pharmaceutical ingredient (API). The impurities were identified as
Iwona Dams, Anna Ostaszewska, Maria Puchalska, Justyna Chmiel, Piotr Cmoch, Iwona Bujak, Agata Białońska, Wojciech J. Szczepek   +7 more
doaj   +1 more source

Molecularly Imprinted Poly(Trimethylolpropane Triacrylate‐Co‐Ethylene Glycol Dimethacrylate‐Co‐Methacrylic Acid) Monolithic Sorbent for Pipette‐Tip Solid‐Phase Extraction of N‐Nitrosodimethylamine in Medicaments

SEPARATION SCIENCE PLUS, Volume 8, Issue 9, September 2025.
ABSTRACT A novel pipette‐tip solid‐phase extraction method was developed using a molecularly imprinted monolithic sorbent composed of poly(trimethylolpropane triacrylate‐co‐ethylene glycol dimethacrylate‐co‐methacrylic acid) for the selective extraction of N‐nitrosodimethylamine from pharmaceutical formulations.
Allyson Leandro Rodrigues dos Santos, Bruna Bezerra de Melo, Anizio Marcio de Faria   +2 more
wiley   +1 more source

Enhancement of Solubility and Dissolution Rate of Olmesartan Medoxomil by Solid Dispersion Technique

, 2021
The enhancement of dissolution rate and oral bioavailability of poorly soluble drugs remains one of the most challenging aspects of drug development.
Janeesha, P
core  

Bioequivalence evaluation of two amlodipine salts, besylate and orotate, each in a fixed-dose combination with olmesartan in healthy subjects

Drug Design, Development and Therapy, 2015
Soo-Yun Lee,1 Jung-Ryul Kim,2,3 Jin Ah Jung,4 Wooseong Huh,2,5 Mi Young Bahng,6 Jae-Wook Ko1,2 1Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, Republic of Korea; 2Department of Clinical Pharmacology and ...
Lee SY, Kim JR, Jung JA, Huh W, Bahng MY, Ko JW   +5 more
doaj  

Effects of Two Allisartan Isoproxil‐Based Antihypertensive Therapies on Sexual Function and Blood Pressure in Male Hypertensive Patients: A Single‐Center, Open‐Label, and Randomized Controlled Trial

The Journal of Clinical Hypertension, Volume 27, Issue 9, September 2025.
ABSTRACT This study evaluated the effects of allisartan isoproxil combined with amlodipine besylate tablets (Group A+C) or metoprolol succinate extended‐release tablets (Group A+B) on sexual function and nighttime blood pressure (nBP) in 130 male patients with essential hypertension (EH). Patients were randomized to two groups.
Mingming Wang, Jianshu Chen, Miaomiao Qi, Runmin Sun, Zhangyou Long, Quanbin Su, Yanhong Mou, Hengxia Liu, Qiongying Wang, Qiang Wu, Xiaowei Zhang, Jing Yu   +11 more
wiley   +1 more source

Validated voltammetric determination of olmesartan medoxomil: Method development and electrochemical behaviors investigation

, 2013
In this study, a sensitive, simple and rapid voltammetric method was developed and validated for the determination of olmesartan medoxomil in pharmaceutical formulations.
ÇELEBİER, MUSTAFA, Altinoz, SACİDE, SÜSLÜ, İNCİLAY   +2 more
core   +1 more source

Blocker, angiotensin II receptor olmesartan to interrupt cardiovascular continuum: vesselsand cardioprotective, anti-atherosclerotic and metabolic pleiotropic effects (part 2)

КардиоСоматика, 2015
The article provides an overview of pleiotropic activity and clinical efficacy of one of the representatives of the class of angiotensin receptor blockers II - olmesartan medoxomil.
M. G Bubnova
doaj  

The Preferential Inhibitory Effect of Olmesartan, a New Angiotensin II Type 1 Antagonist, on Sympathetic Nerve Terminals in Isolated Canine Splenic Artery

Journal of Pharmacological Sciences, 2003
Effects of olmesartan (RNH-6270: (5-methyl-2-oxo-1,3-dioxolen-4-yl)methoxy-4-(1-hydroxy-1-methylethyl)-2-propyl{4-[2-(tetrazol-5-yl)-phenyl]phenyl}methylimidazol-5-carboxylase, an active form of olmesartan medoxomil (CS-866)) was investigated in isolated,
Shigetoshi Chiba, Xiao-Ping Yang
doaj   +1 more source

Efficacy and safety of traditional Chinese medicine and SGLT2i, GLP‐1RA, and ACEI/ARB in the management of diabetic kidney disease: A systematic review and network meta‐analysis

Rheumatology &Autoimmunity, Volume 5, Issue 1, Page 37-49, March 2025.
A network meta‐analysis was carried out to identify the most recommended therapeutic schedule for patients with diabetic kidney disease. The study finally included 87 randomized‐controlled trials, including 16 different treatments and 10,485 patients.
Jiarong Liu, Jixiong Xu
wiley   +1 more source

Rational Design of Palladium and Platinum Chemosensors for Bio‐Applications

Advanced Sensor Research, Volume 4, Issue 2, February 2025.
Precious group 10 d‐block metals, particularly palladium, and platinum, are widely utilized in various industries. However, their widespread use comes at a cost with potentially adverse effects to human health and the environment. This review which surveys the chemosensing mechanism and practical applications of palladium and platinum sensor probes ...
Daniel Nnaemaka Tritton, Chak‐Shing Kwan, Fung‐Kit Tang, Zongwei Cai, Min Li, Ken Cham‐Fai Leung   +5 more
wiley   +1 more source