Results 91 to 100 of about 52,364 (182)

P-glycoprotein Limits the Brain Penetration of Olopatadine Hydrochloride, H1-Receptor Antagonist

Drug Metabolism and Pharmacokinetics, 2008
Olopatadine, a new second-generation antihistamine, is widely used in the treatment of allergic disorders. The low levels of histamine H1 receptor occupancy in human brain by olopatadine, which is related to its minimal sedation, suggest its low penetration into the brain.
MIMURA, Nobuhito, NAGATA, Yoshinori, KUWABARA, Takashi, KUBO, Nobuo, FUSE, Eiichi   +4 more
openaire   +2 more sources

A Randomized Prospective Open Label Comparative Study of Olopatadine with Sodium Cromoglycate in Allergic Conjunctivitis [PDF]

, 2017
BACKGROUND : Allergic conjunctivitis is the second most common cause of ocular morbidity in India and it accounts about20% of cases attending ophthalmology clinics. Ocular itching and nasal symptoms adversely affect the quality of life of patients. AIM
Sanu, Sain
core  

Comparative efficacy of bepotastine besilate 1.5% ophthalmic solution versus olopatadine hydrochloride 0.1% ophthalmic solution in allergic conjunctivitis

Journal of Dr. NTR University of Health Sciences
Aim: To compare the efficacy of topical bepotastine 1.5% and olopatadine 0.1% ophthalmic solutions in relieving ocular signs and symptoms of mild to moderate allergic conjunctivitis.
Sunkara Charitha, Kavitha Mandalapu, Bhavya Kadiri, Undrakonda Vivekanand   +3 more
doaj   +1 more source

Comparison of pharmacokinetics and safety characteristics between two olopatadine hydrochloride 5 mg tablet formulations in healthy Korean subjects. [PDF]

Transl Clin Pharmacol, 2021
Kim JH, Lee M, Kim N, Oh TY, Nam SK, Choi YS, Kwon IS, Jung JG, Hong JH.   +8 more
europepmc   +1 more source

Evaluation of the effects of olopatadine ophthalmic solution, 0.2% on the ocular surface of patients with allergic conjunctivitis and dry eye

, 2008
Purpose: Olopatadine hydrochloride 0.2% (Pataday † , Alcon, Fort Worth, USA) is a topical ocular anti-allergic agent that has shown high rates of efficacy in treating ocular itching, the primary symptom of allergic conjunctivitis, and allows for once ...
Mah, F. S, Kim, T, Torkildsen, G, O'Brien, T   +3 more
core   +1 more source

Topical Use of Olopatadine and Cyclosporine a in Treatment of Vernal Keratoconjunctivitis

, 2016
Aim: To compare the efficacy and safety of Olopatadine hydrochloride (0.1%) with Cyclosporine A ophthalmic solution (0.05%) in treating the signs and symptoms of VKC. Material and Method: Twenty-five patients with VKC were included in a prospective study.
Fikret, Akata, Zaure, Knatova, Eugeniu, Vieru, Aylin, Kantarci Feride   +3 more
core   +1 more source

Olopatadine: a drug for allergic conjunctivitis targeting the mast cell

, 2010
IMPORTANCE OF THE FIELD: Ocular allergic diseases are characterized by specific activation of conjunctival mast cells with subsequent release of preformed and newly formed mediators.
LEONARDI, ANDREA, QUINTIERI, LUIGI
core   +1 more source

Permeability and biocompatibility evaluation of olopatadine hydrochloride viscous ophthalmic solutions using in vitro 3D corneal model

, 2021
Olopatadine is a selective H1-receptore antagonist that inhibits release of histamine and proinflammatory mediators [1]. The poor ocular bioavailability, as the main limitation of efficient ocular therapy, could be overcome by increasing residence ...
Dobričić, Vladimir, Račić, Anđelka, Krajišnik, Danina, Milić, Jela, Lovrić, Jasmina, Jurišić Dukovski, Bisera, Čalija, Bojan   +6 more
core   +1 more source

Comparative efficacy of caffeic acid phenethyl ester (CAPE), olopatadine hydrochloride, and dexamethasone sodium phosphate in experimental allergic conjunctivitis

, 2010
Conclusion: This study demonstrated that 1% CAPE was as clinically efficacious as 0 1% olopatadine and 0 1% dexamethasone. Thus, 1% CAPE may be an alternative to 0 1% olopatadine and 0 1% dexamethasone in the management of acute allergic ...
Erkorkmaz, Ünal
core   +1 more source

Voltammetric determination of chlorpromazine hydrochloride and promethazine hydrochloride with the use of multivariate calibration

, 2001
The voltammetric behavior of antipsychotic drugs, such as, chlorpromazine hydrochloride and promethazine hydrochloride has been investigated at a glassy carbon electrode in Britton–Robinson buffer of pH 9.
Wang, li, Kokot, Serge, Li Wang, Yongnian Ni, Ni, Yongnian, Serge Kokot   +5 more
core   +1 more source