Results 71 to 80 of about 56,153 (181)

Pharmacological, Pharmacokinetic and Clinical Properties of Olopatadine Hydrochloride, a New Antiallergic Drug

Japanese Journal of Pharmacology, 2002
Olopatadine hydrochloride (olopatadine, 11-[(Z)-3-(dimethylamino)propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid monohydrochloride) is a novel antiallergic/histamine H1-receptor antagonistic drug that was synthesized and evaluated in our laboratories. Oral administration of olopatadine at doses of 0.03 mg/kg or higher inhibited the symptoms of
Ohmori, Kenji, Hayashi, Ken-ichi, Kaise, Toshihiko, Ohshima, Etsuo, Kobayashi, Satoshi, Yamazaki, Takashi, Mukouyama, Akimichi   +6 more
openaire   +3 more sources

Intranasal corticosteroid and antihistamine combinations in the treatment of allergic rhinitis: the role of the novel formulation olopatadine/mometasone furoate

, 2023
IntroductionAllergic rhinitis (AR) is a common disease with an important impact on the quality of life and very high management costs. In many patients, the poor control of rhinitis symptoms often requires the use of different drugs, and polytherapy ...
Giovanni Paoletti, Luca Malvezzi, Paoletti, Giovanni, Heffler, Enrico, Erminia Ridolo, Giorgio Walter Canonica, Alessandro Barone, Enrico Heffler, Canonica, Giorgio Walter, Francesca Nicoletta, Nicoletta, Francesca, Malvezzi, Luca, Ridolo, Erminia, Barone, Alessandro   +13 more
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Safety and efficacy of olopatadine hydrochloride nasal spray for the treatment of seasonal allergic rhinitis [PDF]

, 2005
Background: A nasal spray containing the antiallergy agent olopatadine hydrochloride is being developed for the treatment of seasonal allergic rhinitis (SAR).
Brubaker, M J, Potts, S L, Meltzer, E O, Barnes, J R, Wall, G M, Larsen, L V, Roland, P S, Berger, W E, Marple, B F, Bernstein, D I, Hampel, F C, Silver, L H, Ratner, P H, Finn, A F, Dimas, C   +14 more
core  

Spectrophotometric Determination of Olopatadine Hydrochloride in Eye Drops and Tablets

Journal of Pharmaceutical Research, 2013
Optimized and validated three UV spectrophotometric methods have been proposed for the determination of olopatadine hydrochloride in different dosage forms (eye drop and tablets) and bulk drug. The developed methods viz. linear regression equation (LRE), standard absorptivity (SA) and first order derivative (FOD) method were validated for linearity ...
D. Jain, P. K. Basniwal
openaire   +1 more source

Effects of olopatadine hydrochloride on the release of thromboxane B2 and histamine from nasal mucosa after antigen–antibody reaction in guinea pigs

, 2001
BackgroundVarious mediators, such as thromboxane (TX) A2, peptide leukotrienes (P-LT) and histamine, are involved in allergic nasal obstruction. The aim of the present study was to investigate the mechanism whereby olopatadine hydrochloride, a novel anti-
Ishii, Akio, Karasawa, Akira, Ohmori, Kenji, Kaise, Toshihiko, Akamatsu, Yukino   +4 more
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Limbitis Secondary to Autologous Serum Eye Drops in a Patient with Atopic Keratoconjunctivitis

Case Reports in Ophthalmological Medicine, 2011
Purpose. Report a case of limbitis secondary to autologous serum eye drops in a patient with atopic keratoconjunctivitis. Design. Interventional case report. Methods.
Jeffrey David Welder, Pejman Bakhtiari, Ali R. Djalilian   +2 more
doaj   +1 more source

Effect of olopatadine hydrochloride, a novel antiallergic agent, on the QT interval in dogs.

Folia Pharmacologica Japonica, 2001
Olopatadine hydrochloride (olopatadine), a novel antiallergic agent, is effective in the treatment of allergic rhinitis, chronic urticaria, eczema and dermatitis. It has been reported that terfenadine and astemizole cause side effects on the circulatory system such as QT prolongation followed by serious ventricular arrhythmias (torsades de pointes). To
IWAMOTO, Ken-ichiro, IKEDA, Jun-ichi, NITO, Masaaki, KOSAKA, Nobuo, ICHIKAWA, Shunji, KOBAYASHI, Hiroyuki, OHMORI, Kenji   +6 more
openaire   +3 more sources

Allergic Conjunctivitis and Contact Lenses: Experience with Olopatadine Hydrochloride 0.1% Therapy [PDF]

Acta Ophthalmologica Scandinavica, 2000
ABSTRACT.Objective: The efficacy of Patanol®, a topically applied anti‐allergic agent, was evaluated in a group of patients with allergic conjunctivitis due to contact lens wear (GROUP I) and a group comprised of seasonal allergic conjunctivitis patients, vernal conjunctivitis patients and atopic keratoconjunctivitis patients (GROUP II).Methods: One ...
openaire   +2 more sources

Development and in vitro/in vivo evaluation of thermo-sensitive in situ gelling systems for ocular allergy

Brazilian Journal of Pharmaceutical Sciences
Ocular allergy is one of the most common disorders of the eye surface. Following diagnosis this condition is typically treated with preparations containing antihistamines.
Umay Merve Güven, Murat Sami Berkman, Behiye Şenel, Yasemin Yazan   +3 more
doaj   +1 more source

Development and Method Validation of HPLC Method as an Key Method in the Analysis of Olopatadine HCl [PDF]

Olopatadine hydrochloride (HCl) is a widely used second-generation antihistamine, and its accurate quantification is critical to ensure product quality and therapeutic efficacy.
Arbah, Windy Annisa, Handoyo, Theodorus Rexa, Djohansah, Violetta   +2 more
core   +1 more source