Results 141 to 150 of about 52,364 (182)

Comparing the effectiveness of four antihistamines with olopatadine in healthy Thoroughbred horses.

J Vet Med Sci
Ikeda Y, Kuroda T, Mita H, Tamura N, Ohta M.   +4 more
europepmc   +1 more source

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Molecular modeling and solubility of olopatadine hydrochloride polymorphs

Computational and Theoretical Chemistry, 2023
Ademir J Camargo, Pal Perjési, Hamilton B Napolitano   +2 more
exaly   +2 more sources

Conformation and conformational exchange of Olopatadine hydrochloride

Journal of Molecular Structure, 2008
Abstract Besides the assignments of the 13 C and 1 H shifts by 1D and 2D NMR, the experiment 1 H spectra of Olopatadine hydrochloride were recorded at temperature range 228–338 K. The variable-temperature spectra revealed a dynamic NMR effect which is attributed to conformational interconversion of the drug.
Yu-Xin Cui
exaly   +2 more sources

Rapid Effects of Olopatadine Hydrochloride on the Histamine‐Induced Skin Responses

Journal of Dermatology, 2002
AbstractOlopatadine hydrochloride is one of the second‐generation nonsedating antihistamines that are used for treating allergic disorders such as urticaria, rhinitis, and atopic dermatitis. We examined the inhibitory effects of this drug on the flare and wheal responses induced by histamine iontophoresis at 30, 60, and 90 min after oral administration
Masutaka Furue
exaly   +3 more sources

Pharmacology, clinical efficacy and safety of olopatadine hydrochloride

Expert Review of Clinical Immunology, 2006
Olopatadine is a multimechanism anti-allergic agent that inhibits H(1) receptor activation and stabilizes mast cell membranes, blocking the release of allergic and inflammatory mediators. Studies in human conjunctival mast cells clearly demonstrate, in the relevant tissue and species, olopatadine's inhibition of histamine release, which was ...
Steven J, Lichtenstein, Mark B, Abelson
openaire   +2 more sources

Fabrication and evaluation of Olopatadine hydrochloride ocular inserts

Journal of Plastic Film & Sheeting, 2020
Development of the novel delivery provides optimal drug delivery via facilitated transcorneal penetration and ultimately improved retention time in eye. The present study was to fabricate and evaluate the performance of ocular inserts of Olopatadine hydrochloride by consuming polymers such as hydroxypropyl methylcellulose, gelatin, and chitosan at ...
Junaid Qureshi, Furqan Muhammad Iqbal, Farwa Hussain, Hira Ijaz, Muhammad Fakhruddin Aamir, Mehreen Afzal   +5 more
openaire   +1 more source

Properties of Olopatadine Hydrochloride, a New Antiallergic/Antihistamine Drug

Arzneimittelforschung, 2011
Olopatadine hydrochloride (CAS 140462-76-6, KW-4679, AL-4943A; hereinafter referred to as olopatadine) is a novel antiallergic drug that is a selective histamine H1 receptor antagonist possessing inhibitory effects on the release of inflammatory lipid mediators such as leukotriene and thromboxane from human polymorphonuclear leukocytes and eosinophils.
Kenji, Ohmori, Kazuhide, Hasegawa, Tadafumi, Tamura, Kiyomi, Miyake, Masahiro, Matsubara, Shigehiro, Masaki, Akira, Karasawa, Naoko, Urayama, Kaori, Horikoshi, Jiro, Kajita, Masanori, Hasegawa, Koji, Taniguchi, Toshio, Komada, Yuji, Kawamoto   +13 more
openaire   +2 more sources

Structural and Physicochemical Studies of Olopatadine Hydrochloride Conformational Polymorphs

Journal of Pharmaceutical Sciences, 2016
Crystal and molecular structures of 2 conformational polymorphs (forms I and II) of olopatadine hydrochloride, an antiallergic agent, are presented. Both crystal modifications crystallize in the monoclinic crystal system with 1 olopatadine hydrochloride molecule in the Z configuration in the asymmetric unit.
Marta, Łaszcz, Kinga, Trzcińska, Anna, Witkowska, Agnieszka, Ciesielska, Katarzyna, Badowska-Rosłonek, Krzysztof, Kuziak   +5 more
openaire   +2 more sources