Results 11 to 20 of about 263 (155)

Long-term efficacy and safety of erenumab in patients with chronic migraine in whom prior preventive treatments had failed: A subgroup analysis. [PDF]

Headache, 2022
Abstract Objective To assess the long‐term efficacy and safety of erenumab in the subgroup of patients with chronic migraine (CM) in whom prior preventive treatments had failed (TF) (≥1, ≥2, and ≥3 TF medication categories) and never failed (preventive naïve or prior preventive treatments had not failed), using the data from a 52‐week, open‐label ...
Ashina M, Tepper SJ, Brandes JL, Reuter U, Boudreau GP, Weatherall M, Gantenbein AR, Doležil D, Klatt J, Wang A, Karanam AK, Cheng S, Mikol DD.   +12 more
europepmc   +2 more sources

Efficacy and Safety of Erenumab in Adults With Medication Overuse Headache: Final Results From a Phase 4 Randomized Placebo-Controlled Study. [PDF]

Eur J Neurol
ABSTRACT Background Erenumab‐induced medication overuse headache (MOH) remission in participants with chronic migraine (CM) in a prospective, Phase 4, randomized, placebo‐controlled trial with an open‐label treatment period (OLTP). We present 1‐year results from the combined double‐blind treatment period (DBTP) and OLTP for the stratified nonopioid ...
Tepper SJ, Dodick DW, Lanteri-Minet M, Dolezil D, Gil-Gouveia R, Lucas C, Piasecka-Stryczynska K, Szabó G, Mikol DD, Chehrenama M, Chou DE, Liu Z, da Silva Lima GP.   +12 more
europepmc   +2 more sources

P782: A PHASE 2, RANDOMIZED TRIAL EVALUATING THE SAFETY AND EFFICACY OF POZELIMAB AND CEMDISIRAN IN PATIENTS WITH PAROXYSMAL NOCTURNAL HEMOGLOBINURIA [PDF]

Hemasphere, 2023
HemaSphere, Volume 7, Issue S3, August 2023.
Jang J, Wong R, Pavani R, Aurand L, Nguyen Q, Perlee L, Souttou A, Weyne J, Kelly R.   +8 more
europepmc   +2 more sources

P797: A PHASE 2, OPEN-LABEL STUDY EVALUATING THE SAFETY AND EFFICACY OF COMBINATION POZELIMAB AND CEMDISIRAN THERAPY IN PATIENTS WITH PAROXYSMAL NOCTURNAL HEMOGLOBINURIA WHO SWITCH FROM ECULIZUMAB [PDF]

Hemasphere, 2023
HemaSphere, Volume 7, Issue S3, August 2023.
Kelly R, Houghton N, Munir T, Muus P, Youngs N, Aurand L, Senk B, Pavani R, Perlee L, Souttou A, Griffin M.   +10 more
europepmc   +2 more sources

Implementation of Data Backup and Synchronization Based on Identity Column Real Time Data Warehouse

Lontar Komputer, 2020
Failure in the process of loading data from the Online Transactional Processing(OLTP) system to the Normalized Data Store (NDS) database can occur. This caused by a disruption in the network so that the OLTP system is unable to save data to the OLTP and ...
I Gede Adnyana, I Made Dwi Jendra Sulastra   +1 more
doaj   +1 more source

OLTP in wonderland [PDF]

Proceedings of the Ninth International Workshop on Data Management on New Hardware, 2013
For several decades, online transaction processing has been one of the main applications that drives innovations in the data management ecosystem, and in turn the database and computer architecture communities. Despite the novel approaches from industry and various research proposals from academia, recent studies emphasize that OLTP workloads still ...
Pınar Tözün, Brian Gold, Anastasia Ailamaki   +2 more
openaire   +1 more source

Query Performance Prediction Based on Physical Operation-level Models [PDF]

Jisuanji kexue, 2022
Query performance prediction (QPP) is an important issue in database systems.When there are concurrent transactions in a database system,the existing methods fail to establish an accurate model without changing query performance.In this paper,a new ...
WANG Run-an, ZOU Zhao-nian
doaj   +1 more source

OLTP on hardware islands

Proceedings of the VLDB Endowment, 2012
Modern hardware is abundantly parallel and increasingly heterogeneous. The numerous processing cores have nonuniform access latencies to the main memory and to the processor caches, which causes variability in the communication costs. Unfortunately, database systems mostly assume that all processing cores are the same and that microarchitecture ...
Porobic, Danica, Pandis, Ippokratis, Branco, Miguel, Tözün, Pınar, Ailamaki, Anastasia   +4 more
openaire   +3 more sources

Evaluation of vascular risk in patients with migraine with and without aura treated with erenumab: Post hoc analysis of pooled long‐term clinical trial data

Headache: The Journal of Head and Face Pain, Volume 63, Issue 3, Page 418-428, March 2023., 2023
Abstract Objective To assess cardiovascular (CV) safety of erenumab in clinical trial patients associated with degree of CV risk. Background Hypertension has been considered a theoretical risk associated with the inhibition of the calcitonin gene‐related peptide pathway in migraine management, particularly in a patient population with pre‐existing CV ...
David Kudrow, Rima Dafer, David W. Dodick, Amaal Starling, Jessica Ailani, Carrie Dougherty, Kavita Kalidas, Feng Zhang, Rohini Jeswani, Nishil Patel, Ani C. Khodavirdi   +10 more
wiley   +1 more source

Post hoc analysis of clinical trial data and pharmacokinetic data to assess wearing‐off of erenumab within monthly treatment cycle

Headache: The Journal of Head and Face Pain, Volume 63, Issue 2, Page 233-242, February 2023., 2023
Abstract Background Treatment wearing‐off has been reported for calcitonin gene‐related peptide‐pathway monoclonal antibodies, including erenumab, specifically in the last week of the monthly dosing cycle. Objective We sought to determine the consistency of erenumab effect throughout the monthly treatment cycle.
David W. Dodick, Andrew M. Blumenfeld, Rashmi B. Halker Singh, Rachel Williams, Feng Zhang, Po‐Wei Chen, Cheng‐Pang Hsu, Cheng Peng, Josefin Snellman, Mahan Chehrenama, Jessica Ailani   +10 more
wiley   +1 more source