Results 1 to 10 of about 19,180 (155)

Real‐World Clinical Outcomes and Corticosteroid Tapering in Telitacicept‐Based Therapy for Ocular Myasthenia Gravis: An Exploratory Analysis by Prior Treatment History [PDF]

Brain and Behavior
Introduction Ocular myasthenia gravis (OMG) is an autoantibody‐mediated disease characterized by extraocular muscle weakness. Telitacicept has shown potential in treating autoimmune diseases, but its efficacy and corticosteroid‐tapering outcomes in OMG ...
Siyu Xie, Wenli Song, Ran Guo, Chunrong Li, Manman Zhang, Yifan Cheng, Wenting Guo, Bo Jin, Jia Li, Yiqi Wang   +9 more
doaj   +3 more sources

OMG! A proteomic determinant of neurodegenerative resiliency [PDF]

Molecular Neurodegeneration
Background Biofluid proteomics can enhance our understanding of the neurodegenerative mechanisms underlying Alzheimer’s disease and related dementias (ADRDs). Oligodendrocyte myelin glycoprotein (OMG) is a brain-specific protein implicated in myelination,
Michael R. Duggan, Hamilton Se-Hwee Oh, Philipp Frank, Gabriela T. Gomez, David Zweibaum, Yuhan Cui, Jingsha Chen, Aditya Surapaneni, Cassandra O. Blew, Heather E. Dark, Cassandra M. Joynes, Sridhar Kandala, Murat Bilgel, Amelia Farinas, Guray Erus, Qu Tian, Julián Candia, Krishna A. Pucha, Bennett A. Landman, Logan Dumitrescu, Timothy J. Hohman, Alexandria Lewis, Abhay Moghekar, Fatemeh Siavoshi, Muhammad Ali, Menghan Liu, Ying Xu, Daniel Western, Naoto Kaneko, Shintaro Kato, Makio Furuichi, Masaki Shibayama, Masahisa Katsuno, Yukiko Nishita, Rei Otsuka, Rebecca F. Gottesman, Eric B. Dammer, Nicholas T. Seyfried, Allan I. Levey, Erik C. B. Johnson, Elizabeth Mormino, Anthony D. Wagner, Kathleen L. Poston, Dimitrios Kapogiannis, Morgan E. Grams, Pavan Bhargava, Iwao Waga, Christos Davatzikos, Susan M. Resnick, Luigi Ferrucci, David A. Bennett, Carlos Cruchaga, Tony Wyss-Coray, Mika Kivimäki, Josef Coresh, Keenan A. Walker   +55 more
doaj   +3 more sources

Molecular glues: Recent advances in cereblon substrate identification and mechanistic insights. [PDF]

Smart Mol
Molecular glues exert diverse core biological functions by inducing or stabilizing protein–protein interactions, extending far beyond the traditional scope of targeted protein degradation. Key breakthroughs include expanded cereblon substrate recognition, sustained G protein‐coupled receptor megacomplex signaling, and the first orthosteric molecular ...
Guan Q, Shi X, Yang Q, Jiang X, Liu X, Zhan P.   +5 more
europepmc   +2 more sources

Comparative study of ocular and generalized myasthenia gravis in a South Korean cohort. [PDF]

PLoS ONE
PurposeTo compare ocular myasthenia gravis (OMG) and generalized myasthenia gravis (GMG) in a South Korean cohort through an integrated analysis of clinical characteristics, diagnostic findings, and treatment patterns.MethodsWe conducted a retrospective ...
Chaerin Kwon, Jeeyoung Oh, Hyun Jin Shin
doaj   +2 more sources

Validation and clinical utility of OMGRate and MG-QOL15 in evaluating symptoms and quality of life in Chinese patients with ocular myasthenia gravis [PDF]

Frontiers in Neurology
PurposeThis study aimed to evaluate the value of the OMGRate and MG-QOL 15 in assessing quality of life (QoL) before and after treatment in ocular myasthenia gravis (OMG) and to validate the applicability of OMGRate in the Chinese OMG population ...
Ting Tang, Qiwen Feng, Qiwen Feng, Youran Cai, Yuying Dong, Jian Chen, Rijia Zhang, Qing Zhou   +7 more
doaj   +2 more sources

Targeted inhibition of inflammatory liver macrophages with a multifunctional nanoparticle ameliorates metabolic dysfunction–associated steatohepatitis [PDF]

Bioactive Materials
Despite metabolic dysfunction–associated steatohepatitis (MASH) being a significant global health concern, there are few effective ways to prevent or treat MASH.
Kaige Chen, Lulu Wang, Liang Liu, Chad A. Arledge, Hui-Kuan Lin, Jingmei Lin, Amyn A. Habib, Dawen Zhao   +7 more
doaj   +2 more sources

Exploring the Value of Quantitative Muscle Ultrasound in Neuromuscular Junction Disorders: A Pilot Study. [PDF]

Muscle Nerve
ABSTRACT Introduction/Aims Quantitative muscle ultrasound (QMUS) is a validated technique for assessing muscle pathology, yet its role in disorders primarily affecting the neuromuscular junction (NMJ) remains unclear. This pilot study aimed to explore whether QMUS is associated with structural muscle changes in patients with acquired or genetic NMJ ...
Pogosean A, Liik M, van Alfen N, Punga AR.   +3 more
europepmc   +2 more sources

Robotic thymectomy for ocular myasthenia gravis: a case series from a UK tertiary centre [PDF]

BMJ Neurology Open
Background Ocular myasthenia gravis (oMG), characterised by ptosis and diplopia, may progress to generalised MG (gMG). Thymectomy is established for seropositive gMG, but its role in oMG remains unclear.
David Lawrence, Jennifer Spillane, Thomas Roberts, Stephen Cone, Alessandro Maraschi, Kunal Bhakhri   +5 more
doaj   +2 more sources

Ocular myasthenia gravis management [PDF]

Frontiers in Neurology
Ocular myasthenia gravis (OMG) has no agreed-upon diagnostic and management criteria, leading to misdiagnoses and often misguided treatments. The purpose of this minireview is to provide guidance to clinicians who encounter possible OMG patients. We cite
Mark J. Kupersmith, Gil I. Wolfe, Henry Kaminski   +2 more
doaj   +2 more sources

Desarrollo de nuevos diseños vegetales: Mejora genética vs transformación genética y edición génica

Magna Scientia UCEVA, 2021
El objetivo de esta reflexión es realizar un estudio comparativo sobre la eficacia, eficiencia técnica y costo de las tecnologías más importantes para el desarrollo de nuevos diseños vegetales, incluyendo la mejora genética, la transformación genética y ...
Pedro Martínez Gómez
doaj   +1 more source