Results 101 to 110 of about 407,505 (399)

Decreased Serum 5‐HT: Clinical Correlates and Regulatory Role in NMJ of MG

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although 5‐Hydroxytryptamine (5‐HT) indirectly stimulates muscle contraction and participates in regulating Acetylcholine receptor (AChR) cluster homeostasis in cellular, animal, and clinical studies, evidence regarding its potential to modulate muscle contraction in myasthenia gravis (MG) remains limited.
Xinru Shen, Jing Zhang, Xinyue Zhou, Xiaoxiao Yu, Haodong Shang, Shufan Chen, Lulu Zhen, Jinru Wu, Guanlian Hu, Xiaoyan Zhu, Zhan Sun, Yiren Wang, Jiahui Wang, Jie Lv, Xue Zhao, Yingna Zhang, Wei Guo, Ying Peng, Feng Gao   +18 more
wiley   +1 more source

Whole-genome profiling of age- and sex-associated DNA methylation signatures in human plasma cell-free DNA

Communications Medicine
Background Age and sex significantly impact DNA methylation patterns, however, existing datasets typically include only a subset of methylation sites in the human genome, hindering our thorough understanding.
Wei Chen, Jinjin Xu, Guodan Zeng, Rijing Ou, Changlin Yang, Chuang Xu, Yeqin Wang, Xinxin Wang, Qiuyan Li, Chenhui Zhao, Wenwen Zhou, Yu Lin, Wending Pang, Haiqiang Zhang, Jianhua Yin, Yan Zhang, Xin Jin   +16 more
doaj   +1 more source

Single-cell sequencing to multi-omics: technologies and applications

Biomarker Research
Cells, as the fundamental units of life, contain multidimensional spatiotemporal information. Single-cell RNA sequencing (scRNA-seq) is revolutionizing biomedical science by analyzing cellular state and intercellular heterogeneity.
Xiangyu Wu, Xin Yang, Yunhan Dai, Zihan Zhao, Junmeng Zhu, Hongqian Guo, Rong Yang   +6 more
semanticscholar   +1 more source

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

Tracking the origin of bacterial DNA in blood: Indication of localized and sporadic transfer from other body sites

Gut Microbes Reports
Recent studies propose the existence of a blood microbiome, but its composition, origin, and dynamics remain largely unresolved. In this pilot study, we analyzed the bacterial DNA present in the blood of 10 volunteers by comparing the taxonomic profiles ...
Maija Rozenberga, Rihards Saksis, Ilze Elbere, Liga Birzniece, Monta Briviba, Ilze Konrade, Janis Klovins   +6 more
doaj   +1 more source

Breakthroughs in the discovery and use of different peroxidase isoforms of microbial origin

AIMS Microbiology, 2020
Peroxidases are classified as oxidoreductases and are the second largest class of enzymes applied in biotechnological processes. These enzymes are used to catalyze various oxidative reactions using hydrogen peroxide and other substrates as electron ...
Pontsho Patricia Twala, Alfred Mitema, Cindy Baburam, Naser Aliye Feto   +3 more
doaj   +1 more source

What Is New about the Exposome? Exploring Scientific Change in Contemporary Epidemiology [PDF]

, 2020
In this commentary, I discuss the scientific changes brought by the exposome, asking what is new about this approach and line of research. I place the exposome in a historical perspective, by analyzing the conditions under which the exposome has been ...
Canali, Stefano
core  

Partition Quantitative Assessment (PQA): A quantitative methodology to\n assess the embedded noise in clustered omics and systems biology data [PDF]

, 2021
Diego A. Camacho-Hernández, Victor E. Nieto-Caballero, José E. León-Burguete, Julio A. Freyre-González   +3 more
openalex   +1 more source

Deciphering spatial domains from spatial multi-omics with SpatialGlue

Nature Methods
Advances in spatial omics technologies now allow multiple types of data to be acquired from the same tissue slice. To realize the full potential of such data, we need spatially informed methods for data integration.
Yahui Long, Kok Siong Ang, Raman Sethi, Sha Liao, Yang Heng, L. van Olst, Shuchen Ye, Chengwei Zhong, Hang Xu, Di Zhang, Immanuel Kwok, Nazihah Husna, Min Jian, Lai Guan Ng, Ao Chen, Nicholas R J Gascoigne, David Gate, Rong Fan, Xun Xu, Jinmiao Chen   +19 more
semanticscholar   +1 more source

Development of a Prediction Model for Progression Risk in High‐Grade Gliomas Based on Habitat Radiomics and Pathomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate the value of constructing models based on habitat radiomics and pathomics for predicting the risk of progression in high‐grade gliomas. Methods This study conducted a retrospective analysis of preoperative magnetic resonance (MR) images and pathological sections from 72 patients diagnosed with high‐grade gliomas (52 ...
Yuchen Zhu, Yuxi Gong, Weilin Xu, Xingjian Sun, Gefei Jiang, Lei Qiu, Kexin Shi, Mengxing Wu, Yinjiao Fei, Jinling Yuan, Jinyan Luo, Yurong Li, Yuandong Cao, Minhong Pan, Shu Zhou   +14 more
wiley   +1 more source