Results 71 to 80 of about 407,505 (399)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Mind-life continuity: a qualitative study of conscious experience [PDF]

, 2017
There are two fundamental models to understanding the phenomenon of natural life. One is thecomputational model, which is based on the symbolic thinking paradigm. The other is the biologicalorganism model.
Hipólito, Inês, Martins, J.
core   +1 more source

BANKSY unifies cell typing and tissue domain segmentation for scalable spatial omics data analysis

Nature Genetics
Spatial omics data are clustered to define both cell types and tissue domains. We present Building Aggregates with a Neighborhood Kernel and Spatial Yardstick (BANKSY), an algorithm that unifies these two spatial clustering problems by embedding cells in
Vipul Singhal, Nigel Chou, Joseph Lee, Yifei Yue, Jinyue Liu, Wan Kee Chock, Li Lin, Yun-Ching Chang, E. Teo, Jonathan Aow, Hwee Kuan Lee, Kok Hao Chen, Shyam Prabhakar   +12 more
semanticscholar   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

An Efficient Nitroblue Tetrazolium Staining and Bright-Field Microscopy Based Method for Detecting and Quantifying Intracellular Reactive Oxygen Species in Oocytes, Cumulus Cells and Embryos

Frontiers in Cell and Developmental Biology, 2020
Assessment of intracellular reactive oxygen species (ROS) is important for evaluating the developmental ability of cumulus-oocyte complexes (COC) and embryos.
Pradeep K. Javvaji, Pradeep K. Javvaji, Arindam Dhali, Joseph R. Francis, Joseph R. Francis, Atul P. Kolte, Anjumoni Mech, Sudhir C. Roy, Ashish Mishra, Raghavendra Bhatta   +9 more
doaj   +1 more source

Application of the Multi-Omics Liquid Biopsy Method M2P-HCC in Early Liver Cancer Screening for High-Risk Individuals with Hepatitis B-Related Liver Cancer [PDF]

, 2023
Xian Yu, Xue-Zhong Lei
openalex   +1 more source

Revolutionizing multi-omics analysis with artificial intelligence and data processing

Quant. Biol.
Our understanding of intricate biological systems has been completely transformed by the development of multi‐omics approaches, which entail the simultaneous study of several different molecular data types.
Ali Yetgin
semanticscholar   +1 more source

MOGONET integrates multi-omics data using graph convolutional networks allowing patient classification and biomarker identification

Nature Communications, 2021
To fully utilize the advances in omics technologies and achieve a more comprehensive understanding of human diseases, novel computational methods are required for integrative analysis of multiple types of omics data.
Tongxin Wang, Wei Shao, Zhi Huang, Haixu Tang, J. Zhang, Zhengming Ding, Kun Huang   +6 more
semanticscholar   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

MetExploreViz: web component for interactive metabolic network visualization [PDF]

, 2017
Summary: MetExploreViz is an open source web component that can be easily embedded in any web site. It provides features dedicated to the visualization of metabolic networks and pathways and thus offers a flexible solution to analyse omics data in a ...
Chazalviel, Maxime, Cottret, Ludovic, Frainay, Clément, Gloaguen, Yoann, Jourdan, Fabien, Merlet, Benjamin, Poupin, Nathalie, Vinson, Florence   +7 more
core   +4 more sources