Results 81 to 90 of about 407,505 (399)

Navigating Challenges and Opportunities in Multi-Omics Integration for Personalized Healthcare

Biomedicines
The field of multi-omics has witnessed unprecedented growth, converging multiple scientific disciplines and technological advances. This surge is evidenced by a more than doubling in multi-omics scientific publications within just two years (2022–2023 ...
Alex E Mohr, Carmen P. Ortega-Santos, Corrie M. Whisner, Judith Klein-Seetharaman, Paniz Jasbi   +4 more
semanticscholar   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Optimization of multi-ancestry polygenic risk score disease prediction models

Scientific Reports
Polygenic risk scores (PRS) have ushered in a new era in genetic epidemiology, offering insights into individual predispositions to a wide range of diseases.
Jon Lerga-Jaso, Andrew Terpolovsky, Biljana Novković, Alex Osama, Charlie Manson, Sandra Bohn, Adriano De Marino, Mark Kunitomi, Puya G. Yazdi   +8 more
doaj   +1 more source

Multidisciplinary teaching of Biotechnology and Omics sciences [PDF]

, 2017
In the last years, there was a great boom in the Omics fields that have developed as multidisciplinary sciences. They use laboratory techniques related to Biology and Chemistry but also Bioinformatics tools. However, the developmental progress of these
Canovas-Ramos, Francisco Miguel, Cantón, Francisco R., Cañas, Rafael A., De la Torre, Fernando, El-Azaz Ciudad, Jorge, Pascual, Belen M, Ávila, Concepción   +6 more
core  

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Single‐cell multi‐omics analysis identifies dynamic regulation of SREBF1 in Alzheimer’s disease [PDF]

, 2021
Vivek Swarup, Samuel Morabito, Emily Miyoshi, Neethu Michael, Saba Shahin, Alessandra Cadete Martini, Elizabeth Head, Justine Silva, Kelsey Leavy, Mari Perez‐Rosendahl   +9 more
openalex   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

The beetle fauna of Dominica, Lesser Antilles (Insecta: Coleoptera) : diversity and distribution [PDF]

, 2006
The beetle fauna of the island of Dominica is summarized. It is presently known to contain 269 genera, and 361 species (in 42 families), of which 347 are named at a species level. Of these, 62 species are endemic to the island.
Peck, Stewart B.
core   +1 more source

Systems biology in animal sciences [PDF]

, 2011
Systems biology is a rapidly expanding field of research and is applied in a number of biological disciplines. In animal sciences, omics approaches are increasingly used, yielding vast amounts of data, but systems biology approaches to extract ...
Bannink, A., Pas, M.F.W., te, Smits, M.A., Veerkamp, R.F., Woelders, H.   +4 more
core   +3 more sources

Hands‐on protocol for preparing water‐soluble fractions from agri‐food samples for NMR‐based metabolomics analysis

FEBS Open Bio, EarlyView.
This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso, Jaime Hiniesta‐Valero, Alejandra Guerra‐Castellano, Miguel A. De la Rosa, Irene Díaz‐Moreno   +4 more
wiley   +1 more source