Results 31 to 40 of about 79,872,456 (309)

Early identification of hERG liability in drug discovery programs by automated patch clamp

Frontiers in Pharmacology, 2014
Blockade of the cardiac ion channel coded by hERG can lead to cardiac arrhythmia, which has become a major concern in drug discovery and development.
Timm eDanker, Clemens eMöller
doaj   +1 more source

Operculigera Clamp 1991

, 2003
Operculigera Clamp, 1991 Diagnosis. Solitary, loricate, with lorica aperture consisting of simple opening without either folded lips at its anterior and posterior edges or invaginated collar of lorica material (loricastome). Aperture closable by means
Kane, John R., Clamp, John C.
core   +1 more source

Classical and numerical approaches to determining V-section band clamp axial stiffness [PDF]

, 2014
V-band clamp joints are used in a wide range of applications to connect circular flanges, for ducts, pipes and the turbocharger housing. Previous studies and research on V-bands are either purely empirical or analytical with limited applicability on the ...
Khodabakhshi, Goodarz, Barrans, Simon, Muller, Matthias, Khodabakhshi Goodarz, Barrans, Simon M., Muller Matthias, Barrans Simon M.   +6 more
core   +1 more source

Transient outward K+ current (ITO) reduction prolongs action potentials and promotes afterdepolarisations: a dynamic-clamp study in human and rabbit cardiac atrial myocytes [PDF]

, 2012
Background and aim: Human atrial transient outward K+ current (ITO) is decreased in a variety of cardiac pathologies, but how ITO reduction alters action potentials (AP) and arrhythmia mechanisms is poorly understood, owing to non-selectivity of ITO ...
Marshall, G.E., Dempster, J., Smith, G.L., Rankin, A.C., Workman, A.J.   +4 more
core   +1 more source

High accuracy, low cost ultrasonic clamp-on flow metering of small diameter, thin walled pipe

, 2023
A new, miniature design of a clamp-on ultrasonic transit-time difference flow meter for use in liquids is presented, with particular application to small diameter, thin walled metal pipes, opening up new areas of application, including smart water ...
Smith, Luke D., Greenshields, David, Li, Z., Burton, T., Dixon, Steve M., Burton, R.   +5 more
core   +1 more source

A Hybrid Model for Safety Pharmacology on an Automated Patch Clamp Platform: Using Dynamic Clamp to Join iPSC-Derived Cardiomyocytes and Simulations of Ik1 Ion Channels in Real-Time

Frontiers in Physiology, 2018
An important aspect of the Comprehensive In Vitro Proarrhythmia Assay (CiPA) proposal is the use of human stem cell-derived cardiomyocytes and the confirmation of their predictive power in drug safety assays.
Birgit Goversen, Nadine Becker, Sonja Stoelzle-Feix, Alison Obergrussberger, Marc A. Vos, Toon A. B. van Veen, Niels Fertig, Teun P. de Boer   +7 more
doaj   +1 more source

Design of the thermomechanical clamp joint of materials with shape memory effect for unmanned aerial vehicle

Научный вестник МГТУ ГА, 2022
Currently, materials with shape memory effect (SME) are widely utilized in the field of joining thin-walled shells. The application of SME materials in the joining of unmanned aerial vehicle (UAV) compartments makes it possible to increase the accuracy ...
Ya. A. Kupriyanova
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

A Quasi-Resonant ZVZCS Phase-Shifted Full-Bridge Converter with an Active Clamp in the Secondary Side

Energies, 2018
A novel Pulse-Width-Modulation (PWM) quasi-resonant active-clamp phase-shifted full-bridge converter is presented and analyzed in this paper. In the proposed topology, an active-clamp switch and a clamp capacitor that resonates with the leakage ...
Duong Tran, Nam Vu, Woojin Choi
doaj   +1 more source

There is no F in APC: Using physiological fluoride-free solutions for high throughput automated patch clamp experiments

Frontiers in Molecular Neuroscience, 2022
Fluoride has been used in the internal recording solution for manual and automated patch clamp experiments for decades because it helps to improve the seal resistance and promotes longer lasting recordings.
Markus Rapedius, Alison Obergrussberger, Edward S. A. Humphries, Stephanie Scholz, Ilka Rinke-Weiss, Tom A. Goetze, Nina Brinkwirth, Maria Giustina Rotordam, Tim Strassmaier, Aaron Randolph, Søren Friis, Aiste Liutkute, Aiste Liutkute, Aiste Liutkute, Fitzwilliam Seibertz, Fitzwilliam Seibertz, Fitzwilliam Seibertz, Niels Voigt, Niels Voigt, Niels Voigt, Niels Fertig   +20 more
doaj   +1 more source