Results 41 to 50 of about 79,872,456 (309)

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source

Blood RNA Biomarker Signatures for Early Diagnosis and Prognosis in Ischemic and Hemorrhagic Stroke: The IBIS‐CT1 Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau, Marie Bruguet, Irina Viakhireva‐Dovganyuk, François‐Mathias Merrien, Denis Marechal, Aurore Jourdain, Philippe Goas, Jordan Coris, Julien Asselineau, Maëlys Consigny, Gérald Le Gac, Serge Timsit   +11 more
wiley   +1 more source

RNA-binding fluorogenic probes: G-clamp conjugated with a thiazole orange derivative for screening RNA-binding small molecules [PDF]

RSC Chemical Biology
RNA has emerged as an attractive target for drug discovery, increasing the importance of methods for identifying RNA-binding small molecules. Fluorescent indicator displacement (FID) assays are commonly used for screening such molecules. However, because
Ryosuke Nagasawa, Kazumitsu Onizuka, Ryohei Iwata, Kosuke Tsuzuki, Kaoru R. Komatsu, Emi Miyashita, Sayaka Dantsuji, Hirotaka Murase, Hirohide Saito, Fumi Nagatsugi   +9 more
doaj   +1 more source

Operculigera madagascarensis Clamp 1992

, 2016
O. madagascarensis Clamp, 1992 Museum Depositions. USNM. 43094 Holotype; 43095, 43096, 43097, 43098 Paratypes. Habitat. Freshwater. Distribution. BR: Ethiopian.
Mayén-Estrada, Rosaura, Clamp, John C.
core   +1 more source

Molecular Diagnosis in Children With Febrile Seizures: Beyond the Conventional Clinical Classification

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Febrile seizures (FS) are currently classified as simple or complex primarily to describe seizure characteristics, with limited ability to identify the underlying etiology. We evaluated whether molecular diagnosis could complement conventional classification and improve the diagnosis and management of FS.
Jia Wang, Mengna Zhang, Yangyang Wang, Xiuyu Shi, Baoguang Li, Xiuxia Wang, Dan Sun, Sanqing Xu, Jianbo Zhao, Lijun Du, Qiming Pang, Xiaoming Liu, Chunhui Tang, Xiaohua Li, Jiuwei Li, Yanli Ma, Jianxiang Liao, Gulixian Abudureyimu, Jianmin Liang, Yuan Wang, De Wu, Jian Wu, Liping Zou   +22 more
wiley   +1 more source

Impact of robotic partial nephrectomy with and without ischemia on renal functions: experience in 34 cases

Urology Research and Practice, 2019
Objective: In this study we aimed to compare renal functions in patients who underwent robotic partial nephrectomy (RPN) with on-clamp and zero- ischemia techniques.
Kemal Ener, Abdullah Erdem Canda, Serkan Altınova, Ali Fuat Atmaca, Erdal Alkan, Erem Asil, Muhammet Fuat Özcan, Ziya Akbulut, Mevlana Derya Balbay   +8 more
doaj   +1 more source

Operculigera obstipa Clamp 1991

, 2016
O. obstipa Clamp, 1991 Museum Depositions. USNM. 42694 Holotype; 42695 Paratype. Habitat. Freshwater. Distribution. BR: Australian. Australia: New South Wales, Mt. Kosciusko (36 ° 28 ' 13.31 "S, 148 ° 15 ' 55.34 "E). Hosts.
Mayén-Estrada, Rosaura, Clamp, John C.
core   +1 more source

A Numerical–Experimental Approach for Multi‐Matrix Fiber‐Reinforced Plastics Characterization Using Finite Element Model Updating

Advanced Engineering Materials, EarlyView.
A numerical–experimental framework is developed for characterizing multi‐matrix fiber‐reinforced polymers (MM‐FRPs) combining epoxy and polyurethane matrices. Harmonic bending tests are integrated with finite element model updating (FEMU) to simultaneously identify elastic and viscoelastic material parameters.
Rodrigo M. Dartora, Tales V. Lisbôa, Axel Spickenheuer, Rogério J. Marczak, Jakson M. Vassoler   +4 more
wiley   +1 more source

System Approach for Building of Calcium-Binding Sites in Proteins

Biomolecules, 2020
We introduce five new local metal cation (first of all, Ca2+) recognition units in proteins: Clampn,(n−2), Clampn,(n−1), Clampn,n, Clampn,(n+1) and Clampn,(n+2).
Alexander I. Denesyuk, Sergei E. Permyakov, Mark S. Johnson, Konstantin Denessiouk, Eugene A. Permyakov   +4 more
doaj   +1 more source

Drain-Source Voltage-Controllable Three-Switch Active-Clamp Forward Converter for Wide Input/Output Voltage Applications

Micromachines, 2022
Active-clamp forward converters are applied to various medium-capacity power systems because they have a relatively simple structure and are capable of zero-voltage switching.
Jeong-Woo Lim, Chong-Eun Kim
doaj   +1 more source