Results 121 to 130 of about 47,819,563 (268)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Structural design, accuracy analysis, and mechanical calibration of a small two-component docking mechanism for large loads in space

Scientific Reports
Currently, the passive part of the space station platform’s docking device has been finalized, emphasizing the need for a docking mechanism that enables the on-orbit assembly of large payloads using in-situ resources.
Jule Zhang, Junjie Li, Chong Zhao, Ke Wang, Congmin Lv   +4 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Thermal Analysis of Digital Transceiving Unit (DTU) for 400 kg-Class Communication Satellite Considering On-Orbit Environment

IEEE Access
Low Earth Orbit(LEO) communication satellites have emerged as a key technology driving the evolution of global communications technology, owing to their capacity for high data transmission rates and extensive coverage area.
Jiye Bak, Hyun-Guk Kim, Jungil Cho, Seong-Ju Lee, Won-Seok Lee, Kyoung Youl Park, Ki Chul Kim   +6 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Multi-objective optimisation of many-revolution, low-thrust orbit raising for Destiny mission

, 2013
This work will present a Multi-Objective approach to the design of the initial, Low-Thrust orbit raising phase for JAXA’s proposed technology demonstrator mission DESTINY.
Kawakatsu, Yasuhiro, Vasile, Massimiliano, Zuiani, Federico   +2 more
core  

Editorial: Robotic Manipulation and Capture in Space

Frontiers in Robotics and AI, 2022
Evangelos Papadopoulos, Farhad Aghili, Ou Ma, Roberto Lampariello   +3 more
doaj   +1 more source

SLD-YOLO: A Lightweight Satellite Component Detection Algorithm Based on Multi-Scale Feature Fusion and Attention Mechanism

Remote Sensing
Space-based on-orbit servicing missions impose stringent requirements for precise identification and localization of satellite components, while existing detection algorithms face dual challenges of insufficient accuracy and excessive computational ...
Yonghao Li, Hang Yang, Bo Lü, Xiaotian Wu   +3 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Self-organising low Earth orbit constellations for Earth observation

, 2014
This paper presents a novel method of manipulating the spatial pattern of a fractionated micro-satellite constellation in Low Earth Orbit. The method developed allows satellites to manipulate the longitudinal position of their ground-tracks over the ...
McInnes, Colin, Mushet, Garrie
core