Results 121 to 130 of about 67,240,934 (242)
An aerostable drag-sail device for the deorbit and disposal of sub-tonne, low earth orbit spacecraft [PDF]
, 2006 There is an increasing amount of debris in low Earth orbit arising from the disintegration and collision of old spacecraft which have not been removed from orbit. A ‘bolt-on’ deorbit device to be attached to new spacecraft is therefore proposed, which
Harkness, Patrick George
core +1 more source
Data in BriefThis data article presents the CubeSat Cybersecurity Dataset for Intrusion Detection (CuCD-ID), a collection of labelled command and telemetry data designed to support machine learning-based security research for space systems. The data were generated in
Yasamin Fayyaz +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
AerospaceThis paper presents an architecture and strategy for on-orbit software updating of satellite payload control systems, based on a tightly coupled DSP and FPGA design.
Peijun Zhong +5 more
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
A passive satellite deorbiting strategy for medium Earth orbit using solar radiation pressure and the J(2) effect [PDF]
, 2012 The growing population of space debris poses a serious risk to the future of space flight. To effectively manage the increase of debris in orbit, end-of life disposal has become a key requirement for future missions.
Colombo, Camilla +2 more
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source