Results 101 to 110 of about 51,151,627 (314)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Demo 17-18 Resistance Wires

, 2001
The resistance of a wire is directly proportional to its length and its resistivity, and inversely proportional to its area. The effect of length, area, and resistivity are shown in this demonstration, which is seen in Figure 1.

core  

Large-scale structure of brown rat (Rattus norvegicus) populations in England: effects on rodenticide resistance [PDF]

, 2015
The brown rat (Rattus norvegicus) is a relatively recent (
Eleanor P. Jones, Mohd Z.H. Haniza, R. H. Smith (7659080), Jones, Eleanor P., Adams, Sally, Sally Adams, MacNicoll, Alan, Mark S. Lambert, Eamonn B. Mallon, S. Adams (1469704), Mallon, Eamonn B., M. S. Lambert (7659083), Haniza, Mohd Z.H., Alan MacNicoll, Eamonn Bernard Mallon (7607027), Smith, Robert H., Robert H. Smith, E. P. Jones (7659074), M. Z. Haniza (7659071), A. M. MacNicoll (7659077), Lambert, Mark S.   +20 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Experimental Characterization of Frequency-Dependent Series Resistance and Inductance for Ground Shielded On-Chip Interconnects [PDF]

, 2013
This paper presents an exhaustive analysis of the frequency-dependent series resistance and inductance associated with the distributed model of on-chip interconnects including a ground shield to reduce substrate losses.
Reydezel Torres Torres, MONICO LINARES ARANDA, DIEGO MAURICIO CORTES HERNANDEZ, OSCAR GONZÁLEZ DÍAZ   +3 more
core  

Cross-sectional survey to assess the status of antimicrobial stewardship programs in public Chilean hospitals

Antimicrobial Resistance and Infection Control
Background Antimicrobial resistance is a leading cause of death worldwide, with the highest burdens in low-resource settings. Antimicrobial stewardship programs (ASP) are coordinated interventions designed to improve and measure the appropriate use of ...
Ruth Rosales, Claudio González, José Valderrama, Tomás Reyes-Barros, Carmen Gloria Núñez, Báltica Cabieses, José M. Munita, Tania Herrera   +7 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

2011 progress towards implementation of a public health action plan to combat antimicrobial resistance [PDF]

In 2001, the Task Force developed an initial Action Plan, outlining specific issues, goals, and actions important for addressing the problem of AR. This document, entitled A Public Health Action Plan to Combat Antimicrobial Resistance, Part I: Domestic ...

core  

The HIV-1 subtype C epidemic in South America is linked to the United Kingdom.

PLoS ONE, 2010
BackgroundThe global spread of HIV-1 has been accompanied by the emergence of genetically distinct viral strains. Over the past two decades subtype C viruses, which predominate in Southern and Eastern Africa, have spread rapidly throughout parts of South
Tulio de Oliveira, Deenan Pillay, Robert J Gifford, UK Collaborative Group on HIV Drug Resistance   +3 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source