Results 111 to 120 of about 543 (229)

Effects of Retinol, Natural Pea Peptide and Antioxidant Blend in a Topical Formulation: In Vitro and Clinical Evidence

Dermatology and Therapy
Introduction Retinol has a long history of treating skin conditions, including photoaging. However, skin irritation with repeated use of retinol is well documented.
Brian Cook, Melanie Riggs, K. C. Holley, Helen Knaggs, Ganesh Diwakar, Edwin D. Lephart   +5 more
doaj   +1 more source

Remimazolam Ameliorates Autistic‐Like Behaviors via Suppression of Ferroptosis in VTA Dopaminergic Neurons in a Mouse Model of ASD

Advanced Science, EarlyView.
The ultra‐short‐acting sedative remimazolam has a sustained therapeutic effect on the core symptoms of VPA‐exposed mice. Remimazolam, a GABA agonist, exerts its therapeutic effects by protecting dopamine neurons in the VTA of VPA‐exposed mice. Meanwhile, ferroptosis is the critical mechanism by which remimazolam protects VTA dopaminergic neurons and ...
Yuxin Zhang, Jianwei Lin, Chaoyang Tong, Xin Fu, Mengqin Shan, Yue Huang, Kan Zhang, Jijian Zheng   +7 more
wiley   +1 more source

Gαi1/3 Is a Novel Regulatory Target for RANKL Signal Transduction and Osteoporosis

Advanced Science, EarlyView.
ABSTRACT Osteoporosis, characterized by progressive bone loss and increased fracture risk, is a growing concern as the population ages. Current treatments, though advanced, remain limited, underscoring the necessity for novel therapeutic targets. Recent studies have shown that the immune system plays a key role in osteoporosis, with osteoclasts driving
Chaowen Bai, Mingchao Zhang, Le Liu, Lide Tao, Chenyang Xu, Hao Chai, Xin Shi, Yin Wang, Xiaopei Zhang, Qiong Chen, Dong Liu, Jinyu Bai, Chang She, Xiaozhong Zhou, Cong Cao, Huajian Shan   +15 more
wiley   +1 more source

Brief of 12 Narcolepsy Patients, Public Interest Organizations, Medical Professionals, and Professors of Law and Medicine as Amici Curiae in Support of Defendants-Appellees (Amended to Add Further Signatories) [PDF]

A prior copy of this brief was filed, inadvertently omitting one signatory. This brief has accordingly been amended to correct the error, reflected in the Certificate as to parties and the ...
Duan, Charles
core   +1 more source

Tri–Band and Dual–Response Smart Windows With Asymmetric Mid–Infrared Emissivity for Year–Round Energy Conservation

Advanced Science, EarlyView.
Our promising smart window exhibits exceptional optical properties, enabling the indoor temperature reduction of 12°C during summer and delivering the annual energy savings of 14.2%–24.4% across mid–to–low latitudes. ABSTRACT Building energy consumption accounts for 20%–40% of global energy usage, with windows among the least energy–efficient ...
Cheng Wang, Junwei Liu, Zhihua Zhou, Yuechao Chao, Xueqing Yang, Yan Liang, Yifan Zhou, Weiyi Zhang, Yahui Du, Wufan Wang, Shuqi Zhang, Jinyue Yan   +11 more
wiley   +1 more source

Brief of 11 Narcolepsy Patients, Public Interest Orgnizations, Medical Professionals, and Professors of Law as Amici Curiae in Support of Defendants-Appellees [PDF]

Amici curiae are patients, organizations, medical professionals, and legal scholars who share a common interest in advancing the law toward better patient health and welfare.
Duan, Charles
core   +1 more source

Melatonin does not reduce delirium severity in hospitalized older adults : Results of a randomized placebo-controlled trial [PDF]

Background Delirium is common in older inpatients, causing distress, cognitive decline, and death. Current therapies are unsatisfactory, limited by lack of efficacy and adverse effects. There is an urgent need for effective delirium treatment. Sleep wake
Clayton-Chubb, Daniel, Conyers, Rachel, Lange, Peter W., Lim, Wen Kwang, Maier, Andrea B., Soh, Cheng Hwee, Turbic, Alisa, Watson, Rosie   +7 more
core   +1 more source

Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome

Advanced Science, EarlyView.
Pharmacological SUMOylation inhibition (SUMOi) counteracts tumor immune evasion by unmasking an immunogenic HLA‐I peptide and neoepitope repertoire. By restoring HLA‐I ligand availability through increased antigen processing and presentation, enhanced proteasomal cleavage, and modulated TAP1 peptide affinity, SUMOi boosts tumor immunogenicity ...
Uta M. Demel, Anna Meurer, Badeel Kh. Q. Zaghla, Bilge Atay, Daniel Steiert, Luca V. Hummel, Konstandina Isaakidis, Chuanbing Zang, Michael Korenkov, Marlon Schielin, Schayan Yousefian, Shima Mecklenbräuker, Marieluise Kirchner, Simon Haas, Antonia Busse, Philipp Mertins, Stefan Müller, Matthias Wirth, Martin G. Klatt, Ulrich Keller   +19 more
wiley   +1 more source

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

Daily or intermittent budesonide in preschool children with recurrent wheezing [PDF]

, 2011
Bacharier, Leonard B, Beigelman, Avraham, et al,, Strunk, Robert C   +3 more
core   +2 more sources