Results 121 to 130 of about 543 (229)

Discovery of H2 Receptor Antagonists as Colistin Enhancers by Targeting Acid Stress Response

Advanced Science, EarlyView.
This study identifies YqgB as a key target for restoring colistin susceptibility in mcr‐positive pathogens under acidic conditions by remodeling phospholipid composition and reducing LPS modification. Deep learning‐based screening reveals H2 receptor antagonists as novel colistin adjuvants. Further investigations indicate that ranitidine and famotidine
Jinju Cai, Mengping He, Jianya Luo, Shuang Zhou, Tengyue Zhang, Jianing Li, Zhiqiang Wang, Yuan Liu   +7 more
wiley   +1 more source

Comparison of the Effectiveness of Ivermectin 1% Cream and Ketoconazole 2% Cream in Treating Facial Seborrheic Dermatitis: A Double‐Blind, Randomized, Controlled Clinical Trial

Health Science Reports
Background and Aims Seborrheic dermatitis (SD) is a common, chronic, and relapsing disease affecting the patients’ quality of life. Expanding the treatment armamentarium provides better care for patients. Topical ivermectin, an anti‐inflammatory and anti‐
Mozhdeh Sepaskhah, Fatemeh Shamshiri, Zahra Bagheri   +2 more
doaj   +1 more source

Why was Pavel Negrebetskii Executed?

Slovene, 2020
The paper seeks to contribute to the discussion among historians about the value, as historical sources, of foreign diplomats stationed in Russia. Two young men, Hildebrand von Horn, an envoy extraordinaire of the Danish king, and the Swede Johan Gabriel
Ulla Birgegård
doaj  

Ufmylation‐Deficient DDRGK1 Ameliorates Obesity by Inhibiting FASN‐Mediated Adipocyte Lipogenesis

Advanced Science, EarlyView.
DDRGK1 regulates de novo lipogenesis via stabilization of fatty acid synthase (FASN). DDRGK1‐mediated UFMylation of FASN prevents its ubiquitin–proteasomal degradation. Reduced DDRGK1 expression or mutation at the key UFMylation site enhances FASN degradation and suppresses fatty acid synthesis (FAS), resulting in smaller adipocytes and improved ...
Yin Li, Tangjun Zhou, Xiao Yang, Kewei Rong, Xiankun Cao, Lei Shi, Xin Wang, Hongjin Wan, Lei Cui, Kexin Liu, Tong Xing, Hang Zhang, Chen Zhao, Tingxian Guo, Peixiang Ma, Jie Zhao, An Qin   +16 more
wiley   +1 more source

THE USE OF PSYCHOTROPIC DRUG THERAPY IN BORDERLINE PERSONALITY DISORDER: A CASE REPORT [PDF]

, 2015
It is estimated that around 75% of patients with Borderline Personality Disorder (BPD) are prescribed psychotropic medication during their treatment course, although this is not recommended as first line therapy.
Bradford, Rebecca, Holt, Clare
core   +1 more source

TOGR3, a Proteasome β4 Subunit, Orchestrates Sugar Homeostasis to Trade Off Growth and Thermotolerance in Rice

Advanced Science, EarlyView.
This study identifies a novel thermoregulatory mechanism in rice: TOGR3 partners with 26S proteasome subunits, including TT1, to drive thermoresponsive ubiquitin–proteasome activity, maintaining sugar homeostasis in stomatal regulation to balance growth and stress resistance.
Biyao Zhang, Xiaoyan Wu, Ting Xu, Feifei Guo, Xiaolu Shen, Cuiping Meng, Yanan Wang, Xue Han, Hong Zhao, Yongbiao Xue   +9 more
wiley   +1 more source

Sensory Nerve‐Derived CGRP Controls Osteoclastogenesis by Limiting Macrophage Bioenergetics in Bone Repair

Advanced Science, EarlyView.
Sensory nerves help bones heal. This study shows that the neuropeptide CGRP, released from sensory nerves, slows down macrophage energy production, preventing excessive bone breakdown. By revealing this nerve–immune–metabolism connection, the work provides new insight into how the body balances bone repair and opens doors to targeted treatments ...
Jiaying Liu, Ting Zhang, Yuqing Mu, Lili Li, Ju Jin, Kevin J Dudley, Wendong Gao, Donglin Cai, Fuhua Yan, Lan Xiao, Yin Xiao   +10 more
wiley   +1 more source

The efficacy of glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene vs adapalene monotherapy in mild-to-moderate acne vulgaris: a double-blinded within-person comparative study

Clinical, Cosmetic and Investigational Dermatology, 2019
Kornphaka Kantikosum,1 Yuda Chongpison,2 Natcha Chottawornsak,1 Pravit Asawanonda1 1Division of Dermatology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; 2Center of Excellence in Biostatistics, Research ...
Kantikosum K, Chongpison Y, Chottawornsak N, Asawanonda P   +3 more
doaj  

The behaviour of adult Anopheles gambiae, sub-Saharan Africa’s principal malaria vector, and its relevance to malaria control: a review

Malaria Journal
Background Mosquitoes of the Anopheles gambiae complex are one of the major vectors of malaria in sub-Saharan Africa. Their ability to transmit this disease of major public health importance is dependent on their abundance, biting behaviour ...
Willem Takken, Derek Charlwood, Steve W. Lindsay   +2 more
doaj   +1 more source

Efficacy of Moringa Soy Milk as a Food-Based Intervention on Hemoglobin Levels in Anemic Pregnant Women: A Quasi-Experimental Study in Gorontalo, Indonesia

NAJFNR
Background: Anemia remains a global health challenge, significantly contributing to adverse maternal and obstetric outcomes. Worldwide, its prevalence stands at 37%, rising to 48.9% in Indonesia according to the World Health Organization (WHO) estimates.
Cholifah, Veni Hadju, Mardiana Ahmad, Suryani As'ad, Jumrah   +4 more
doaj   +1 more source