Results 191 to 200 of about 543 (229)

Are there morpho‐acoustic patterns of adaptation in nonhuman primate ears? Testing the role of ecology and habitat in shaping ear morphology and function

The Anatomical Record, EarlyView.
Abstract Analysis of the variation in the bony structures of the inner and middle ear provides critical insights into functional morphology, as well as adaptive morphology across primates. In this study, we investigated whether ear morphology patterns are related to the ecological characteristics of species and their habitats to test two acoustic ...
Myriam Marsot, Rémi Laffont, Émilie Steimetz, Patricia Balaresque, Sébastien Couette   +4 more
wiley   +1 more source

The Slumbering Giant-Slayer: A Modern Day Jekyll and Hyde [PDF]

, 2013
Aysola, Ravi, Bierer, Gregory, Wen, Eugenia   +2 more
core  

Under the Shade of a Coolabah Tree: A Second Cache of Tulas From the Boulia District, Western Queensland

Archaeology in Oceania, EarlyView.
ABSTRACT This paper reports on the excavation of a cache of stone artefacts, buried on the bank of a waterhole or ‘billabong’ in central western Queensland. This is an extremely rare find, and yet it is the second such site to be reported within less than a 10 km radius.
Yinika L. Perston, Lynley A. Wallis, Heather Burke, Lorna Bogdanek, Trevina Rogers, Justine Kemp   +5 more
wiley   +1 more source

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

String Figuring young children's perspectives of quality in English early childhood education and care

British Educational Research Journal, EarlyView.
Abstract Quality in early childhood education and care (ECEC) is a contested concept and has generally been conceptualised by inter‐related indicators such as staff qualifications, educational environment, policy or child‐to‐staff ratios. There has been a more limited emphasis on how young children might perceive and experience quality.
Nikki Fairchild, Éva Mikuska
wiley   +1 more source

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0589 Dose Titration of Once-Nightly Sodium Oxybate: Analysis of Interim Data From RESTORE

SLEEP, 2023
Abstract Introduction FT218 (LUMRYZ™) is an investigational once-nightly sodium oxybate (ON-SXB) for treatment of adults with narcolepsy type 1 (NT1) or type 2 (NT2). The efficacy and safety of ON-SXB at doses 6, 7.5, and 9 g in patients with NT1/NT2 were confirmed in the phase 3 REST-ON clinical ...
Asim Roy, Brian Abaluck, Thomas Stern, Clete Kushida, Jordan Dubow, Jennifer Gudeman   +5 more
openaire   +1 more source

0579 Long-Term Safety of Once-Nightly Oxybate for Narcolepsy: RESTORE Study Interim Analysis of Data

SLEEP, 2023
Abstract Introduction The pivotal phase 3 REST-ON trial (NCT02720744) evaluated the efficacy and safety of once-nightly sodium oxybate (ON-SXB; FT218), an investigational extended-release formulation for treatment of adults with narcolepsy. In REST-ON, ON-SXB met its 3 coprimary endpoints: improvement
Thomas Stern, Asim Roy, Colin Shapiro, John Harsh, Akinyemi Ajayi, Sally Ibrahim, Jordan Dubow, Jennifer Gudeman   +7 more
openaire   +1 more source

0573 Application of AASM Clinical Significance Thresholds to Once-Nightly Sodium Oxybate for Improvement in Narcolepsy Symptoms

SLEEP, 2023
Abstract Introduction Once-nightly sodium oxybate (ON-SXB; FT218), an investigational, extended-release treatment, was evaluated for the treatment of narcolepsy in adults in the phase 3 REST-ON clinical trial (NCT02720744).
Thomas Roth, Michael Thorpy, Clete Kushida, Anne Morse, Jordan Dubow, Jennifer Gudeman, Yves Dauvilliers   +6 more
openaire   +1 more source

0638 Stability of Once-Nightly Sodium Oxybate in Alternative Liquid Reconstitution Vehicles

SLEEP
Abstract Introduction LUMRYZ™ is a once-nightly formulation of sodium oxybate (ON-SXB) containing both immediate and pH-dependent controlled-release granules designed to be reconstituted in water and administered orally.
Maggie Lavender, Ellen Wermter, Anne Morse, Matthew Horsnell, Jason Vaughn, Frederik Ascencion, Jennifer Gudeman   +6 more
openaire   +1 more source

0636 Assessing Usability of Once-Nightly Sodium Oxybate Extended-Release Oral Suspension for Narcolepsy

SLEEP
Abstract Introduction Sodium oxybate, available in once-nightly and twice-nightly formulations, is indicated for treatment of cataplexy or excessive daytime sleepiness in narcolepsy. Once-nightly sodium oxybate extended-release oral suspension (ON-SXB; LUMRYZ™) may alleviate potential dosing ...
Maggie Lavender, Ellen Wermter, Luis Ortiz, Anne Morse, Matthew Horsnell, Jennifer Gudeman   +5 more
openaire   +1 more source