Results 121 to 130 of about 20,920 (295)

Factors Associated with Ivermectin Non-Compliance and Its Potential Role in Sustaining Onchocerca volvulus Transmission in the West Region of Cameroon

PLoS Neglected Tropical Diseases, 2016
Background Community Directed Treatment with ivermectin is the cornerstone of current efforts to eliminate onchocerciasis. However recent studies suggest there are foci where long-term annual distribution of the drug alone has failed to ensure ...
Laura Senyonjo, J. Oye, D. Bakajika, B. Biholong, A. Tekle, D. Boakye, Elena Schmidt, E. Elhassan   +7 more
semanticscholar   +1 more source

Toward 959 nematode genomes [PDF]

, 2012
The sequencing of the complete genome of the nematode Caenorhabditis elegans was a landmark achievement and ushered in a new era of whole-organism, systems analyses of the biology of this powerful model organism. The success of the C.
Blaxter, M, Kaur, G, Koutsovoulos, G, Kumar, S   +3 more
core   +1 more source

Viability of Onchocerca volvulus in vitro

Parasitology, 1993
SUMMARYThe use of a selective schedule of tests to identify a viable population of isolated adult Onchocerca volvulus (Nematoda: Filarioidea) has been investigated in a large worm population. The study was initiated to develop methodology appropriate to test new candidate macrofilaricides for their in vitro activity against O. volvulus.
G. Strote, A. Bokhof, J. C. W. Comley
openaire   +3 more sources

Analysis of age-dependent trends in Ov16 IgG4 seroprevalence to onchocerciasis [PDF]

, 2016
BACKGROUND: Diagnostics provide a means to measure progress toward disease elimination. Many countries in Africa are approaching elimination of onchocerciasis after successful implementation of mass drug administration programs as well as vector control.
Adade, Kangi, Banla, Meba, de los Santos, Tala, Domingo, Gonzalo J, Faulx, Dunia, Gantin, Richard G, Golden, Allison, Kalnoky, Michael, Karabou, Potochoziou, Komlan, Kossi, Peck, Roger, Rao, Ramakrishna, Soboslay, Peter T, Stevens, Eric, Yokobe, Lindsay   +14 more
core   +2 more sources

Sur la structure histologique des nodules à Onchocerca volvulus et à O. cæcutiens [PDF]

, 1935
M Martínez-Báez
openalex   +1 more source

A Recombinant Positive Control for Serology Diagnostic Tests Supporting Elimination of Onchocerca volvulus

PLoS Neglected Tropical Diseases, 2016
Background Serological assays for human IgG4 to the Onchocerca volvulus antigen Ov16 have been used to confirm elimination of onchocerciasis in much of the Americas and parts of Africa.
A. Golden, Eric Stevens, L. Yokobe, D. Faulx, M. Kalnoky, R. Peck, Melissa Valdez, C. Steel, Potochoziou K. Karabou, M. Banla, P. Soboslay, Kangi Adade, A. Tekle, V. Cama, Peter U. Fischer, T. Nutman, T. Unnasch, T. de Los Santos, G. Domingo   +18 more
semanticscholar   +1 more source

Localization of Wolbachia-like gene transcripts and peptides in adult Onchocerca flexuosa worms indicates tissue specific expression [PDF]

, 2013
BACKGROUND: Most filarial species in the genus Onchocerca depend on Wolbachia endobacteria to successfully carry out their life cycle. O. flexuosa is a Wolbachia-free species, but its genome contains Wolbachia-like sequences presumably obtained from ...
Brattig, Norbert W, Curtis, Kurt C, Fischer, Kerstin, Fischer, Peter U, McNulty, Samantha N, Weil, Gary J   +5 more
core   +2 more sources

Modelling Neglected Tropical Diseases diagnostics: the sensitivity of skin snips for Onchocerca volvulus in near elimination and surveillance settings

Parasites & Vectors, 2016
BackgroundThe African Programme for Onchocerciasis Control has proposed provisional thresholds for the prevalence of microfilariae in humans and of L3 larvae in blackflies, below which mass drug administration (MDA) with ivermectin can be stopped and ...
C. Bottomley, V. Isham, S. Vivas-Martínez, A. Kuesel, S. Attah, N. Opoku, S. Lustigman, M. Walker, M. Basáñez   +8 more
semanticscholar   +1 more source

Onchocerciasis Drug Discovery: In Vitro Evaluation of FDA-Approved Drugs against Onchocerca gutturosa in Gambia

Pharmaceutics
Onchocerciasis treatment and control relies mainly on the use of ivermectin which has high activity against the microfilarial stage of Onchocerca volvulus but limited activity against the long-lived, tissue dwelling adult nematodes.
Suzanne Gokool, Simon Townson, Andrew Freeman, Jadzia Siemienski-Kleyn, Jakub Zubrzycki, Senyo Tagboto, Marc P. Hübner, Ivan Scandale   +7 more
doaj   +1 more source

Monoclonal Antibodies as Investigative Tools in Onchocerciasis [PDF]

, 2017
The development of monoclonal antibodies against parasites can facilitate analysis of host-parasite interactions and can lead to the identification and characterization of antigens that induce protective responses in the immunized host.
Weiss, Niklaus
core