Zoonotic Implications of Onchocerca Species on Human Health [PDF]
The genus Onchocerca includes several species associated with ungulates as hosts, although some have been identified in canids, felids, and humans. Onchocerca species have a wide geographical distribution, and the disease they produce, onchocerciasis, is
Maria Cambra-Pellejà+4 more
doaj +5 more sources
Onchocerca jakutensis Filariasis in Humans
We identified Onchocerca jakutensis as the causative agent of an unusual human filariasis in a patient with lupus erythematosus. To our knowledge, this is the first case of human infection with O.
Martina Koehsler+4 more
doaj +4 more sources
Crystal structure of N-terminally hexahistidine-tagged Onchocerca volvulus macrophage migration inhibitory factor-1. [PDF]
N‐terminally hexahistidine‐tagged O. volvulus macrophage migration inhibitory factor‐1 has a unique jellyfish‐like structure with the prototypical macrophage migration inhibitory factor trimer as the `head' and a C‐terminal extension as the `tail'.Onchocerca volvulus causes blindness, onchocerciasis, skin infections and devastating neurological ...
Kimble AD+10 more
europepmc +2 more sources
Development of Onchocerca volvulus in humanized NSG mice and detection of parasite biomarkers in urine and serum. [PDF]
BACKGROUND: The study of Onchocerca volvulus has been limited by its host range, with only humans and non-human primates shown to be susceptible to the full life cycle infection.
Abraham, David+7 more
core +3 more sources
Stage-specific proteomes from onchocerca ochengi, sister species of the human river blindness parasite, uncover adaptations to a nodular lifestyle [PDF]
Despite 40 years of control efforts, onchocerciasis (river blindness) remains one of the most important neglected tropical diseases, with 17 million people affected.
Adam+155 more
core +5 more sources
Twenty-seven species of the genus Onchocerca (Nematoda; Filarioidea) can cause a vector-borne parasitic disease called onchocercosis. Most Onchocerca species infect wild and domestic ungulates or the dog, and one species causes river blindness in humans ...
Felix Bosch+2 more
doaj +1 more source
What's in your next-generation sequence data? An exploration of unmapped DNA and RNA sequence reads from the bovine reference individual. [PDF]
BackgroundNext-generation sequencing projects commonly commence by aligning reads to a reference genome assembly. While improvements in alignment algorithms and computational hardware have greatly enhanced the efficiency and accuracy of alignments, a ...
Alexander, Leeson J+9 more
core +1 more source
The macrofilaricidal efficacy of repeated doses of ivermectin for the treatment of river blindness [PDF]
Background: Mass drug administration (MDA) with ivermectin is the cornerstone of efforts to eliminate human onchocerciasis by 2020 or 2025. The feasibility of elimination crucially depends on the effects of multiple ivermectin doses on Onchocerca ...
Basáñez, Maria-Gloria+12 more
core +2 more sources
Ivermectin inhibits growth of Chlamydia trachomatis in epithelial cells. [PDF]
Ivermectin is currently approved for treatment of both clinical and veterinary infections by nematodes, including Onchocerca cervicalis in horses and Onchocerca volvulus in humans.
Matthew A Pettengill+4 more
doaj +1 more source
The therapeutic efficacy and macrofilaricidal activity of doxycycline for the treatment of river blindness [PDF]
Background. Onchocerca volvulus and lymphatic filariae, causing river blindness and elephantiasis, depend on endosymbiotic Wolbachia bacteria for growth, development, fertility, and survival.
Achim Hoerauf+43 more
core +1 more source